Q9JII6: Aldo-keto reductase family 1 member A1

General Information

Protein names	- Aldo-keto reductase family 1 member A1 - 1.1.1.2 {ECO:0000269\|PubMed:15769935, ECO:0000269\|PubMed:20410296} - 1.1.1.33 {ECO:0000250\|UniProtKB:P51635} - 1.1.1.372 {ECO:0000269\|PubMed:22820017} - 1.1.1.54 {ECO:0000250\|UniProtKB:P51635} - Alcohol dehydrogenase NADP(+)] - Aldehyde reductase - Glucuronate reductase - 1.1.1.19 {ECO:0000269\|PubMed:15769935, ECO:0000269\|PubMed:20410296} - Glucuronolactone reductase {ECO:0000250\|UniProtKB:P51635} - 1.1.1.20 {ECO:0000250\|UniProtKB:P51635}
Gene names	Akr1a1
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9JII6

5 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MTASSVLLHT GQKMPLIGLG TWKSEPGQVK AAIKHALSAG YRHIDCASVY GNETEIGEAL
        70         80         90        100        110        120
KESVGSGKAV PREELFVTSK LWNTKHHPED VEPALRKTLA DLQLEYLDLY LMHWPYAFER
       130        140        150        160        170        180
GDNPFPKNAD GTVRYDSTHY KETWKALEVL VAKGLVKALG LSNFNSRQID DVLSVASVRP
       190        200        210        220        230        240
AVLQVECHPY LAQNELIAHC HARGLEVTAY SPLGSSDRAW RHPDEPVLLE EPVVLALAEK
       250        260        270        280        290        300
HGRSPAQILL RWQVQRKVIC IPKSINPSRI LQNIQVFDFT FSPEEMKQLD ALNKNWRYIV
       310        320
PMITVDGKRV PRDAGHPLYP FNDPY

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
Q9JII6-2-unknown	MTASSV...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9JII6-2-Acetylation	TASSVL...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9JII6-47-unknown	ASVYGN...	47		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31180
Q9JII6-229-unknown	LEEPVV...	229		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29389
Q9JII6-229-unknown	LEEPVV...	229		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31181
Q9JII6-236-unknown	ALAEKH...	236		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31182

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RHIDCA	46	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31180
...HCHARG	203	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000114861
...DEPVLL	228	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29389
...DEPVLL	228	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31181
...EPVVLA	235	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31182
...FNDPY	325	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Evidence name
CATE_MOUSE	46	IDCA.\|.ASVY	inferred from experiment	unknown	MEROPS	Merops CATE_MOUSE -> AK1A1_MOUSE @46
CATD_MOUSE	228	PVLL.\|.LEEP	inferred from experiment	unknown	MEROPS	Merops CATD_MOUSE -> AK1A1_MOUSE @228
CATE_MOUSE	228	PVLL.\|.LEEP	inferred from experiment	unknown	MEROPS	Merops CATE_MOUSE -> AK1A1_MOUSE @228
CATE_MOUSE	235	VVLA.\|.ALAE	inferred from experiment	unknown	MEROPS	Merops CATE_MOUSE -> AK1A1_MOUSE @235

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)