Q9R1T2: SUMO-activating enzyme subunit 1

General Information

Protein names	- SUMO-activating enzyme subunit 1 - Ubiquitin-like 1-activating enzyme E1A - SUMO-activating enzyme subunit 1, N-terminally processed
Gene names	Sae1
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9R1T2

5 N-termini

3 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MVEKEEAGGG GGGGISEEEA AQYDRQIRLW GLEAQKRLRA SRVLIVGMKG LGAEIAKNLI
        70         80         90        100        110        120
LAGVKGLTML DHEQVSPEDP GAQFLIQTGS VGRNRAEASL ERAQNLNPMV DVKVDTEDVE
       130        140        150        160        170        180
KKPESFFTKF DAVCLTCCSR DVIIKVDQIC HRNSIKFFTG DVFGYHGYTF ANLGEHEFVE
       190        200        210        220        230        240
EKTKVAKVSQ GVEDGPEAKR AKLDSSETTM VKKKVLFCPV KEALEVDWSG EKAKAALKRT
       250        260        270        280        290        300
APDYFLLQVL LKFRTDKGRD PTSESYKEDA ELLLQIRNDV FDSLGISPDL LPDDFVRYCF
       310        320        330        340        350
SEMAPVCAVV GGILAQEIVK ALSQRDPPHN NFFFFDGMKG SGIVECLGPQ

Isoforms

- Isoform 2 of SUMO-activating enzyme subunit 1

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
Q9R1T2-1-Acetylation	MVEKEE...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9R1T2-1-Acetylation	MVEKEE...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt97402
Q9R1T2-1-unknown	MVEKEE...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt88835
Q9R1T2-2-Acetylation	VEKEEA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9R1T2-2-Acetylation	VEKEEA...	2	acetylation-	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
Q9R1T2-2-Acetylation	VEKEEA...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt110226
Q9R1T2-85-unknown	LIQTGS...	85		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31312
Q9R1T2-85-unknown	LIQTGS...	85		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141562
Q9R1T2-179-unknown	VEEKTK...	179		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31314
Q9R1T2-179-unknown	VEEKTK...	179		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29431
Q9R1T2-179-unknown	VEEKTK...	179		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145855

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PGAQFL	84	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31312
...PGAQFL	84	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124739
...GEHEFV	178	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31314
...GEHEFV	178	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29431
...GEHEFV	178	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129153
...CLGPQ	350	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Evidence name
CATE_MOUSE	84	AQFL.\|.LIQT	inferred from experiment	unknown	MEROPS	Merops CATE_MOUSE -> SAE1_MOUSE @84
CATE_MOUSE	178	HEFV.\|.VEEK	inferred from experiment	unknown	MEROPS	Merops CATE_MOUSE -> SAE1_MOUSE @178
CATD_MOUSE	178	HEFV.\|.VEEK	inferred from experiment	unknown	MEROPS	Merops CATD_MOUSE -> SAE1_MOUSE @178

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)