Q9CWJ9: Bifunctional purine biosynthesis protein PURH

General Information

Protein names	- Bifunctional purine biosynthesis protein PURH - Phosphoribosylaminoimidazolecarboxamide formyltransferase - 2.1.2.3 - 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase - AICAR transformylase - IMP cyclohydrolase - 3.5.4.10 - ATIC - IMP synthase - Inosinicase
Gene names	Atic
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9CWJ9

14 N-termini

11 C-termini

13 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAPSQLALFS VSDKTGLVEF ARSLASLGLS LVASGGTAKA IRDAGLAVRD VSELTGFPEM
        70         80         90        100        110        120
LGGRVKTLHP AVHAGILARN IPEDAADMAR LDFNLVRVVV CNLYPFVKTV ASPDVTVEAA
       130        140        150        160        170        180
VEQIDIGGVT LLRAAAKNHA RVTVVCEPED YAGVAAEMHG SDSKDTSLET RRHLALKAFT
       190        200        210        220        230        240
HTAQYDEAIS DYFRKQYSKG ISQMPLRYGM NPHQTPAQLY TLKPKLPITV LNGAPGFINL
       250        260        270        280        290        300
CDALNAWQLV TELRGAVDIP AAASFKHVSP AGAAVGVPLS EDEARVCMVY DLYPTLTPLA
       310        320        330        340        350        360
VAYARARGAD RMSSFGDFVA LSDICDVPTA KIISREVSDG IVAPGYEEEA LKILSKKKNG
       370        380        390        400        410        420
NYCVLQMDQS YKPDENEVRT LFGLRLSQKR NNGVVDKSLF SNIVTKNKDL PESALRDLIV
       430        440        450        460        470        480
ATVAVKYTQS NSVCYAKDGQ VIGIGAGQQS RIHCTRLAGD KANSWWLRHH PRVLSMKFKA
       490        500        510        520        530        540
GVKRAEISNA IDQYVTGTIG EGEDLVKWEA LFEEVPELLT EAEKKEWVDK LSGVSVSSDA
       550        560        570        580        590
FFPFRDNVDR AKRSGVAYIV APSGSTADKV VIEACDELGI VLAHTDLRLF HH

Isoforms

Sequence View

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Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

14 N-termini - 11 C-termini - 13 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9CWJ9-1-Acetylation	MAPSQL...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9CWJ9-8-unknown	LFSVSD...	8		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34211
Q9CWJ9-9-unknown	FSVSDK...	9		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31037
Q9CWJ9-9-unknown	FSVSDK...	9		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34212
Q9CWJ9-10-unknown	SVSDKT...	10		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34213
Q9CWJ9-14-unknown	KTGLVE...	14		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34214
Q9CWJ9-32-unknown	VASGGT...	32		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31038
Q9CWJ9-32-unknown	VASGGT...	32		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29339
Q9CWJ9-176-unknown	LKAFTH...	176		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34215
Q9CWJ9-267-unknown	HVSPAG...	267			N-TAILS		Overall CM.	auf dem Keller U.: A statistics-based platform for quantitative N-terminome...	20305283
Q9CWJ9-267-unknown	HVSPAG...	267		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9CWJ9-267-unmodified	HVSPAG...	267			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
Q9CWJ9-319-unknown	VALSDI...	319		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31039
Q9CWJ9-319-unknown	VALSDI...	319		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29340
Q9CWJ9-403-unknown	IVTKNK...	403		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34216
Q9CWJ9-407-unmodified	NKDLPE...	407			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
Q9CWJ9-475-unknown	SMKFKA...	475		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31040
Q9CWJ9-534-unknown	VSVSSD...	534		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34217

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PSQLAL	7	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34211
...SQLALF	8	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31037
...SQLALF	8	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34212
...QLALFS	9	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34213
...FSVSDK	13	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34214
...LGLSLV	31	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31038
...LGLSLV	31	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29339
...RRHLAL	175	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34215
...SFGDFV	318	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31039
...SFGDFV	318	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29340
...SLFSNI	402	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34216
...HPRVLS	474	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31040
...DKLSGV	533	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34217
...RLFHH	592	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	7	QLAL.\|.LFSV	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATE_MOUSE	8	LALF.\|.FSVS	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> PUR9_MOUSE @8
MMP2_MOUSE	8	LALF.\|.FSVS	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	9	ALFS.\|.SVSD	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	13	VSDK.\|.KTGL	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATE_MOUSE	31	LSLV.\|.VASG	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> PUR9_MOUSE @31
CATD_MOUSE	31	LSLV.\|.VASG	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> PUR9_MOUSE @31
MMP2_MOUSE	175	HLAL.\|.LKAF	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATE_MOUSE	318	GDFV.\|.VALS	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> PUR9_MOUSE @318
CATD_MOUSE	318	GDFV.\|.VALS	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> PUR9_MOUSE @318
MMP2_MOUSE	402	FSNI.\|.IVTK	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,
CATE_MOUSE	474	RVLS.\|.SMKF	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> PUR9_MOUSE @474
MMP2_MOUSE	533	LSGV.\|.VSVS	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)