Q9Z0N1: Eukaryotic translation initiation factor 2 subunit 3, X-linked

General Information

Protein names	- Eukaryotic translation initiation factor 2 subunit 3, X-linked - Eukaryotic translation initiation factor 2 subunit gamma, X-linked - eIF-2-gamma X
Gene names	Eif2s3x
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9Z0N1

10 N-termini

6 C-termini

6 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAGGEGGVTL GQPHLSRQDL ATLDVTKLTP LSHEVISRQA TINIGTIGHV AHGKSTVVKA
        70         80         90        100        110        120
ISGVHTVRFK NELERNITIK LGYANAKIYK LDDPSCPRPE CYRSCGSSTP DEFPTDIPGT
       130        140        150        160        170        180
KGNFKLVRHV SFVDCPGHDI LMATMLNGAA VMDAALLLIA GNESCPQPQT SEHLAAIEIM
       190        200        210        220        230        240
KLKHILILQN KIDLVKESQA KEQYEQILAF VQGTVAEGAP IIPISAQLKY NIEVVCEYIV
       250        260        270        280        290        300
KKIPVPPRDF TSEPRLIVIR SFDVNKPGCE VDDLKGGVAG GSILKGVLKV GQEIEVRPGI
       310        320        330        340        350        360
VSKDSEGKLM CKPIFSKIVS LFAEHNDLQY AAPGGLIGVG TKIDPTLCRA DRMVGQVLGA
       370        380        390        400        410        420
VGALPEIFTE LEISYFLLRR LLGVRTEGDK KAAKVQKLSK NEVLMVNIGS LSTGGRVSAV
       430        440        450        460        470
KADLGKIVLT NPVCTEVGEK IALSRRVEKH WRLIGWGQIR RGVTIKPTVD DD

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

10 N-termini - 6 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9Z0N1-2-unknown	MAGGEG...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9Z0N1-2-Acetylation	AGGEGG...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9Z0N1-2-unmodified	AGGEGG...	2			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
Q9Z0N1-20-unknown	LATLDV...	20		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34399
Q9Z0N1-23-unknown	LDVTKL...	23		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34400
Q9Z0N1-24-unknown	DVTKLT...	24		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29446
Q9Z0N1-55-unmodified	STVVKA...	55			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
Q9Z0N1-92-unknown	DDPSCP...	92		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q9Z0N1-336-unknown	LIGVGT...	336		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34401
Q9Z0N1-405-unknown	MVNIGS...	405		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29447
Q9Z0N1-405-unknown	MVNIGS...	405		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31367

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LSRQDL	19	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34399
...QDLATL	22	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34400
...DLATLD	23	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29446
...AAPGGL	335	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34401
...KNEVLM	404	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29447
...KNEVLM	404	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31367
...TVDDD	472	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	19	RQDL.\|.LATL	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	22	LATL.\|.LDVT	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATD_MOUSE	23	ATLD.\|.DVTK	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> IF2G_MOUSE @23
MMP2_MOUSE	335	PGGL.\|.LIGV	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,
CATD_MOUSE	404	EVLM.\|.MVNI	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> IF2G_MOUSE @404
CATE_MOUSE	404	EVLM.\|.MVNI	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> IF2G_MOUSE @404

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)