Q61696: Heat shock 70 kDa protein 1A

General Information

Protein names	- Heat shock 70 kDa protein 1A - Heat shock 70 kDa protein 3 - HSP70.3 - Hsp68
Gene names	Hspa1a
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q61696

5 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAKNTAIGID LGTTYSCVGV FQHGKVEIIA NDQGNRTTPS YVAFTDTERL IGDAAKNQVA
        70         80         90        100        110        120
LNPQNTVFDA KRLIGRKFGD AVVQSDMKHW PFQVVNDGDK PKVQVNYKGE SRSFFPEEIS
       130        140        150        160        170        180
SMVLTKMKEI AEAYLGHPVT NAVITVPAYF NDSQRQATKD AGVIAGLNVL RIINEPTAAA
       190        200        210        220        230        240
IAYGLDRTGK GERNVLIFDL GGGTFDVSIL TIDDGIFEVK ATAGDTHLGG EDFDNRLVSH
       250        260        270        280        290        300
FVEEFKRKHK KDISQNKRAV RRLRTACERA KRTLSSSTQA SLEIDSLFEG IDFYTSITRA
       310        320        330        340        350        360
RFEELCSDLF RGTLEPVEKA LRDAKMDKAQ IHDLVLVGGS TRIPKVQKLL QDFFNGRDLN
       370        380        390        400        410        420
KSINPDEAVA YGAAVQAAIL MGDKSENVQD LLLLDVAPLS LGLETAGGVM TALIKRNSTI
       430        440        450        460        470        480
PTKQTQTFTT YSDNQPGVLI QVYEGERAMT RDNNLLGRFE LSGIPPAPRG VPQIEVTFDI
       490        500        510        520        530        540
DANGILNVTA TDKSTGKANK ITITNDKGRL SKEEIERMVQ EAERYKAEDE VQRDRVAAKN
       550        560        570        580        590        600
ALESYAFNMK SAVEDEGLKG KLSEADKKKV LDKCQEVISW LDSNTLADKE EFVHKREELE
       610        620        630        640
RVCSPIISGL YQGAGAPGAG GFGAQAPKGA SGSGPTIEEV D

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
Q61696-2-unknown	MAKNTA...	1		inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
Q61696-2-unknown	MAKNTA...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q61696-2-Acetylation	AKNTAI...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q61696-2-Acetylation	AKNTAI...	2	acetylation-	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
Q61696-28-unknown	IIANDQ...	28		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30522
Q61696-42-unknown	VAFTDT...	42		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30523
Q61696-440-unknown	IQVYEG...	440		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29166

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...HGKVEI	27	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30522
...TTPSYV	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30523
...QPGVLI	439	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29166
...IEEVD	641	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATE_MOUSE	27	KVEI.\|.IIAN	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> HS71A_MOUSE @27
CATE_MOUSE	41	PSYV.\|.VAFT	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> HS71A_MOUSE @41
CATD_MOUSE	439	GVLI.\|.IQVY	inferred from experiment	unknown	MEROPS	Zornig M	Melzer IM et al.:The Apaf-1-binding protein Aven... (A01.009)	22388353,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)