P15864: Histone H1.2

General Information

Protein names	- Histone H1.2 - H1 VAR.1 - H1c
Gene names	Hist1h1c
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P15864

11 N-termini

7 C-termini

7 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSEAAPAAPA AAPPAEKAPA KKKAAKKPAG VRRKASGPPV SELITKAVAA SKERSGVSLA
        70         80         90        100        110        120
ALKKALAAAG YDVEKNNSRI KLGLKSLVSK GILVQTKGTG ASGSFKLNKK AASGEAKPQA
       130        140        150        160        170        180
KKAGAAKAKK PAGAAKKPKK ATGAATPKKA AKKTPKKAKK PAAAAVTKKV AKSPKKAKVT
       190        200        210
KPKKVKSASK AVKPKAAKPK VAKAKKVAAK KK

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

11 N-termini - 7 C-termini - 7 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P15864-2-unknown	MSEAAP...	1		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P15864-2-unknown	MSEAAP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P15864-2-Acetylation	SEAAPA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P15864-2-Acetylation	SEAAPA...	2	acetylation-		unknown			Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
P15864-2-Acetylation	SEAAPA...	2	acetylation-	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P15864-19-unknown	PAKKKA...	19		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P15864-36-unmodified	SGPPVS...	36			unknown			Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
P15864-43-unknown	LITKAV...	43		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33376
P15864-44-unknown	ITKAVA...	44		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29731
P15864-44-unknown	ITKAVA...	44		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28773
P15864-60-unknown	AALKKA...	60		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29732
P15864-62-unknown	LKKALA...	62		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33377
P15864-66-unknown	LAAAGY...	66		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33378
P15864-67-unknown	AAAGYD...	67		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29733
P15864-70-unmodified	GYDVEK...	70			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PPVSEL	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33376
...PVSELI	43	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29731
...PVSELI	43	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28773
...SGVSLA	59	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29732
...VSLAAL	61	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33377
...ALKKAL	65	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33378
...LKKALA	66	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29733
...AAKKK	212	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	42	VSEL.\|.LITK	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,
CATE_MOUSE	43	SELI.\|.ITKA	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> H12_MOUSE @43
CATD_MOUSE	43	SELI.\|.ITKA	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> H12_MOUSE @43
CATE_MOUSE	59	VSLA.\|.AALK	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> H12_MOUSE @59
MMP2_MOUSE	61	LAAL.\|.LKKA	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,
MMP2_MOUSE	65	KKAL.\|.LAAA	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATE_MOUSE	66	KALA.\|.AAAG	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> H12_MOUSE @66

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)