O88844: Isocitrate dehydrogenase [NADP] cytoplasmic

General Information

Protein names	- Isocitrate dehydrogenase NADP] cytoplasmic - IDH - 1.1.1.42 {ECO:0000269\|PubMed:29923039} - Cytosolic NADP-isocitrate dehydrogenase - IDP - NADP(+)-specific ICDH - Oxalosuccinate decarboxylase
Gene names	Idh1
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	O88844

5 N-termini

5 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSRKIQGGSV VEMQGDEMTR IIWELIKEKL ILPYVELDLH SYDLGIENRD ATNDQVTKDA
        70         80         90        100        110        120
AEAIKKYNVG VKCATITPDE KRVEEFKLKQ MWKSPNGTIR NILGGTVFRE AIICKNIPRL
       130        140        150        160        170        180
VTGWVKPIII GRHAYGDQYR ATDFVVPGPG KVEITYTPKD GTQKVTYMVH DFEEGGGVAM
       190        200        210        220        230        240
GMYNQDKSIE DFAHSSFQMA LSKGWPLYLS TKNTILKKYD GRFKDIFQEI YDKKYKSQFE
       250        260        270        280        290        300
AQKICYEHRL IDDMVAQAMK SEGGFIWACK NYDGDVQSDS VAQGYGSLGM MTSVLICPDG
       310        320        330        340        350        360
KTVEAEAAHG TVTRHYRMYQ KGQETSTNPI ASIFAWSRGL AHRAKLDNNT ELSFFAKALE
       370        380        390        400        410
DVCIETIEAG FMTKDLAACI KGLPNVQRSD YLNTFEFMDK LGENLKAKLA QAKL

Isoforms

Sequence View

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Physiological Relevance:

Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

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Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 5 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
O88844-2-unknown	MSRKIQ...	1		inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
O88844-2-unknown	MSRKIQ...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O88844-2-Acetylation	SRKIQG...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O88844-2-Acetylation	SRKIQG...	2	acetylation-	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
O88844-38-unknown	DLHSYD...	38		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28686
O88844-210-unknown	STKNTI...	210		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29592
O88844-296-unknown	ICPDGK...	296		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28687

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PYVELD	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28686
...YRATDF	143	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000117853
...WPLYLS	209	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29592
...MTSVLI	295	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28687
...AQAKL	414	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Evidence name
CATD_MOUSE	37	VELD.\|.DLHS	inferred from experiment	unknown	MEROPS	Merops CATD_MOUSE -> IDHC_MOUSE @37
CATE_MOUSE	209	LYLS.\|.STKN	inferred from experiment	unknown	MEROPS	Merops CATE_MOUSE -> IDHC_MOUSE @209
CATD_MOUSE	295	SVLI.\|.ICPD	inferred from experiment	unknown	MEROPS	Merops CATD_MOUSE -> IDHC_MOUSE @295

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)