P53657: Pyruvate kinase PKLR

General Information

Protein names	- Pyruvate kinase PKLR - 2.7.1.40 - L-PK - Pyruvate kinase isozymes L/R
Gene names	Pklr
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P53657

4 N-termini

4 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSVQENELPQ QLWPWIFKSQ KDLAKSALSG APGGPAGYLR RASVAQLTQE LGTAFFQQQQ
        70         80         90        100        110        120
LPAAMADTFL EHLCLLDIDS EPVAARSTSI IATIGPASRS VDRLKEMIKA GMNIARLNFS
       130        140        150        160        170        180
HGSHEYHAES IANIREAAES FATSPLSYRP VAIALDTKGP EIRTGVLQGG PESEVEIVKG
       190        200        210        220        230        240
SQVLVTVDPK FRTRGDAKTV WVDYHNITQV VAVGGRIYID DGLISLVVRK IGPEGLVTEV
       250        260        270        280        290        300
EHGGFLGNRK GVNLPNAEVD LPGLSEQDLL DLRFGVEHYV DIIFASFVRK ASDVVAVRDA
       310        320        330        340        350        360
LGPEGRGIKI ISKIENHEGV KKFDEILEVS DGIMMARGDL GIEIPAEKVF LAQKMMIGRC
       370        380        390        400        410        420
NLAGKPVVCA TQMLESMITK ARPTRAETSD VANAVLDGAD CIMLSGETAK GSFPVEAVKM
       430        440        450        460        470        480
QHAIAREAEA AVYHRQLFEE LRRAAPLSRD PTEVTAIGAV EASFKCCAAA IIVLTKTGRS
       490        500        510        520        530        540
AQLLSRYRPR AAVIAVTRSA QAARQVHLSR GVFPLLYREP PEAVWADDVD RRVQFGIESG
       550        560        570
KLRGFLRVGD LVIVVTGWRP GSGYTNIMRV LTIS

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P53657-1-unknown	MSVQEN...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P53657-154-unknown	ALDTKG...	154	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30092
P53657-351-unknown	LAQKMM...	351	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28937
P53657-351-unknown	LAQKMM...	351	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30093
P53657-352-unknown	AQKMMI...	352	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30094

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RPVAIA	153	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30092
...AEKVFL	350	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28937
...AEKVFL	350	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30093
...EKVFLA	351	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30094
...VLTIS	574	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATE_MOUSE	153	VAIA.\|.ALDT	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> KPYR_MOUSE @153
CATD_MOUSE	350	KVFL.\|.LAQK	inferred from experiment	unknown	MEROPS	Zornig M	Melzer IM et al.:The Apaf-1-binding protein Aven... (A01.009)	22388353,
CATE_MOUSE	350	KVFL.\|.LAQK	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> KPYR_MOUSE @350
CATE_MOUSE	351	VFLA.\|.AQKM	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> KPYR_MOUSE @351

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)