P62962: Profilin-1

General Information

Protein names	- Profilin-1 - Profilin I
Gene names	Pfn1
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P62962

12 N-termini

6 C-termini

8 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAGWNAYIDS LMADGTCQDA AIVGYKDSPS VWAAVPGKTF VSITPAEVGV LVGKDRSSFF
        70         80         90        100        110        120
VNGLTLGGQK CSVIRDSLLQ DGEFTMDLRT KSTGGAPTFN VTVTMTAKTL VLLMGKEGVH
       130        140
GGLINKKCYE MASHLRRSQY

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

12 N-termini - 6 C-termini - 8 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P62962-2-unknown	MAGWNA...	1		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P62962-2-unknown	MAGWNA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P62962-2-Acetylation	AGWNAY...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P62962-2-Acetylation	AGWNAY...	2	acetylation-	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P62962-33-unknown	AAVPGK...	33		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29008
P62962-33-unmodified	AAVPGK...	33			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P62962-41-unmodified	VSITPA...	41			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P62962-41-unknown	VSITPA...	41		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30216
P62962-41-unknown	VSITPA...	41		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29009
P62962-42-unmodified	SITPAE...	42			unknown			Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
P62962-42-unmodified	SITPAE...	42			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P62962-60-unknown	FVNGLT...	60		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30217
P62962-60-unknown	FVNGLT...	60		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29010
P62962-64-unknown	LTLGGQ...	64		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30218
P62962-64-unknown	LTLGGQ...	64		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29011
P62962-79-unknown	LQDGEF...	79		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30219
P62962-81-unknown	DGEFTM...	81			N-TAILS		Overall CM.	auf dem Keller U.: A statistics-based platform for quantitative N-terminome...	20305283
P62962-115-unmodified	GKEGVH...	115			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SPSVWA	32	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29008
...PGKTFV	40	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30216
...PGKTFV	40	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29009
...DRSSFF	59	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30217
...DRSSFF	59	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29010
...FFVNGL	63	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30218
...FFVNGL	63	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29011
...IRDSLL	78	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30219
...RRSQY	140	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Evidence name
CATD_MOUSE	32	SVWA.\|.AAVP	inferred from experiment	unknown	MEROPS	Merops CATD_MOUSE -> PROF1_MOUSE @32
CATE_MOUSE	40	KTFV.\|.VSIT	inferred from experiment	unknown	MEROPS	Merops CATE_MOUSE -> PROF1_MOUSE @40
CATD_MOUSE	40	KTFV.\|.VSIT	inferred from experiment	unknown	MEROPS	Merops CATD_MOUSE -> PROF1_MOUSE @40
CATE_MOUSE	59	SSFF.\|.FVNG	inferred from experiment	unknown	MEROPS	Merops CATE_MOUSE -> PROF1_MOUSE @59
CATD_MOUSE	59	SSFF.\|.FVNG	inferred from experiment	unknown	MEROPS	Merops CATD_MOUSE -> PROF1_MOUSE @59
CATE_MOUSE	63	VNGL.\|.LTLG	inferred from experiment	unknown	MEROPS	Merops CATE_MOUSE -> PROF1_MOUSE @63
CATD_MOUSE	63	VNGL.\|.LTLG	inferred from experiment	unknown	MEROPS	Merops CATD_MOUSE -> PROF1_MOUSE @63
CATE_MOUSE	78	DSLL.\|.LQDG	inferred from experiment	unknown	MEROPS	Merops CATE_MOUSE -> PROF1_MOUSE @78

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)