P27661: Histone H2AX

General Information

Protein names	- Histone H2AX - H2a/x - Histone H2A.X
Gene names	H2afx
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P27661

7 N-termini

6 C-termini

7 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSGRGKTGGK ARAKAKSRSS RAGLQFPVGR VHRLLRKGHY AERVGAGAPV YLAAVLEYLT
        70         80         90        100        110        120
AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGG VTIAQGGVLP NIQAVLLPKK
       130        140
SSATVGPKAP AVGKKASQAS QEY

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

7 N-termini - 6 C-termini - 7 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
P27661-2-unknown	MSGRGK...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P27661-2-Acetylation	SGRGKT...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P27661-58-unknown	YLTAEI...	58		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29900
P27661-60-unknown	TAEILE...	60		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28856
P27661-60-unknown	TAEILE...	60		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29901
P27661-62-unknown	EILELA...	62		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28857
P27661-63-unknown	ILELAG...	63		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28858
P27661-63-unknown	ILELAG...	63		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29902
P27661-65-unknown	ELAGNA...	65		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28859

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AAVLEY	57	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29900
...VLEYLT	59	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28856
...VLEYLT	59	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29901
...EYLTAE	61	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28857
...YLTAEI	62	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28858
...YLTAEI	62	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29902
...TAEILE	64	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28859
...ASQEY	143	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATE_MOUSE	57	VLEY.\|.YLTA	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> H2AX_MOUSE @57
CATD_MOUSE	59	EYLT.\|.TAEI	inferred from experiment	unknown	MEROPS	Zornig M	Melzer IM et al.:The Apaf-1-binding protein Aven... (A01.009)	22388353,
CATE_MOUSE	59	EYLT.\|.TAEI	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> H2AX_MOUSE @59
CATD_MOUSE	61	LTAE.\|.EILE	inferred from experiment	unknown	MEROPS	Zornig M	Melzer IM et al.:The Apaf-1-binding protein Aven... (A01.009)	22388353,
CATD_MOUSE	62	TAEI.\|.ILEL	inferred from experiment	unknown	MEROPS	Zornig M	Melzer IM et al.:The Apaf-1-binding protein Aven... (A01.009)	22388353,
CATE_MOUSE	62	TAEI.\|.ILEL	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> H2AX_MOUSE @62
CATD_MOUSE	64	EILE.\|.ELAG	inferred from experiment	unknown	MEROPS	Zornig M	Melzer IM et al.:The Apaf-1-binding protein Aven... (A01.009)	22388353,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)