P08249: Malate dehydrogenase, mitochondrial

General Information

Protein names	- Malate dehydrogenase, mitochondrial - 1.1.1.37
Gene names	Mdh2
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P08249

6 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MLSALARPAG AALRRSFSTS AQNNAKVAVL GASGGIGQPL SLLLKNSPLV SRLTLYDIAH
        70         80         90        100        110        120
TPGVAADLSH IETRANVKGY LGPEQLPDCL KGCDVVVIPA GVPRKPGMTR DDLFNTNATI
       130        140        150        160        170        180
VATLTAACAQ HCPEAMVCII ANPVNSTIPI TAEVFKKHGV YNPNKIFGVT TLDIVRANTF
       190        200        210        220        230        240
VAELKGLDPA RVNVPVIGGH AGKTIIPLIS QCTPKVDFPQ DQLATLTGRI QEAGTEVVKA
       250        260        270        280        290        300
KAGAGSATLS MAYAGARFVF SLVDAMNGKE GVVECSFVQS KETECTYFST PLLLGKKGLE
       310        320        330
KNLGIGKITP FEEKMIAEAI PELKASIKKG EDFVKNMK

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P08249-17-unknown	FSTSAQ...	17	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34641
P08249-25-unknown	AKVAVL...	25	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P08249-25-unmodified	AKVAVL...	25		N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P08249-43-unknown	LLKNSP...	43	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28724
P08249-80-unknown	YLGPEQ...	80	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33279
P08249-95-unknown	VVVIPA...	95	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28725

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ALRRSF	16	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34641
...QPLSLL	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28724
...ANVKGY	79	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33279
...LKGCDV	94	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28725
...VKNMK	338	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MPPB_MOUSE	16	RRSF.\|.FSTS	inferred from experiment	unknown	MEROPS	Rosenberg LE	Hendrick JP et al.:Survey of amino-terminal proteo... (M16.003)	2657736,
CATD_MOUSE	42	LSLL.\|.LLKN	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> MDHM_MOUSE @42
MMP2_MOUSE	79	VKGY.\|.YLGP	inferred from experiment	unknown	MEROPS		Merops MMP2_MOUSE -> MDHM_MOUSE @79
CATD_MOUSE	94	GCDV.\|.VVVI	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> MDHM_MOUSE @94

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)