Q91V92: ATP-citrate synthase

General Information

Protein names	- ATP-citrate synthase - 2.3.3.8 {ECO:0000269\|PubMed:25450640} - ATP-citrate (pro-S-)-lyase - Citrate cleavage enzyme
Gene names	Acly
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q91V92

13 N-termini

11 C-termini

11 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSAKAISEQT GKELLYKYIC TTSAIQNRFK YARVTPDTDW AHLLQDHPWL LSQSLVVKPD
        70         80         90        100        110        120
QLIKRRGKLG LVGVNLSLDG VKSWLKPRLG HEATVGKAKG FLKNFLIEPF VPHSQAEEFY
       130        140        150        160        170        180
VCIYATREGD YVLFHHEGGV DVGDVDAKAQ KLLVGVDEKL NTEDIKRHLL VHAPEDKKEV
       190        200        210        220        230        240
LASFISGLFN FYEDLYFTYL EINPLVVTKD GVYILDLAAK VDATADYICK VKWGDIEFPP
       250        260        270        280        290        300
PFGREAYPEE AYIADLDAKS GASLKLTLLN PKGRIWTMVA GGGASVVYSD TICDLGGVNE
       310        320        330        340        350        360
LANYGEYSGA PSEQQTYDYA KTILSLMTRE KHPEGKILII GGSIANFTNV AATFKGIVRA
       370        380        390        400        410        420
IRDYQGPLKE HEVTIFVRRG GPNYQEGLRV MGEVGKTTGI PIHVFGTETH MTAIVGMALG
       430        440        450        460        470        480
HRPIPNQPPT AAHTANFLLN ASGSTSTPAP SRTASFSESR ADEVAPAKKA KPAMPQGKSA
       490        500        510        520        530        540
TLFSRHTKAI VWGMQTRAVQ GMLDFDYVCS RDEPSVAAMV YPFTGDHKQK FYWGHKEILI
       550        560        570        580        590        600
PVFKNMADAM KKHPEVDVLI NFASLRSAYD STMETMNYAQ IRTIAIIAEG IPEALTRKLI
       610        620        630        640        650        660
KKADQKGVTI IGPATVGGIK PGCFKIGNTG GMLDNILASK LYRPGSVAYV SRSGGMSNEL
       670        680        690        700        710        720
NNIISRTTDG VYEGVAIGGD RYPGSTFMDH VLRYQDTPGV KMIVVLGEIG GTEEYKICRG
       730        740        750        760        770        780
IKEGRLTKPV VCWCIGTCAT MFSSEVQFGH AGACANQASE TAVAKNQALK EAGVFVPRSF
       790        800        810        820        830        840
DELGEIIQSV YEDLVAKGAI VPAQEVPPPT VPMDYSWARE LGLIRKPASF MTSICDERGQ
       850        860        870        880        890        900
ELIYAGMPIT EVFKEEMGIG GVLGLLWFQR RLPKYSCQFI EMCLMVTADH GPAVSGAHNT
       910        920        930        940        950        960
IICARAGKDL VSSLTSGLLT IGDRFGGALD AAAKMFSKAF DSGIIPMEFV NKMKKEGKLI
       970        980        990       1000       1010       1020
MGIGHRVKSI NNPDMRVQIL KDFVKQHFPA TPLLDYALEV EKITTSKKPN LILNVDGFIG
      1030       1040       1050       1060       1070       1080
VAFVDMLRNC GSFTREEADE YVDIGALNGI FVLGRSMGFI GHYLDQKRLK QGLYRHPWDD
      1090
ISYVLPEHMS M

Isoforms

Sequence View

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

13 N-termini - 11 C-termini - 11 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q91V92-1-unknown	MSAKAI...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q91V92-9-unknown	QTGKEL...	9	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34134
Q91V92-21-unknown	TTSAIQ...	21	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30891
Q91V92-52-unknown	SQSLVV...	52	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30892
Q91V92-56-unknown	VVKPDQ...	56	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29276
Q91V92-56-unknown	VVKPDQ...	56	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30893
Q91V92-127-unknown	REGDYV...	127	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q91V92-438-unknown	LLNASG...	438	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30894
Q91V92-439-unknown	LNASGS...	439	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30895
Q91V92-440-unknown	NASGST...	440	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29277
Q91V92-470-unmodified	AKPAMP...	470		N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
Q91V92-584-unknown	IAIIAE...	584	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30896
Q91V92-586-unknown	IIAEGI...	586	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30897
Q91V92-769-unknown	LKEAGV...	769	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34135
Q91V92-769-unknown	LKEAGV...	769	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q91V92-769-unknown	LKEAGV...	769	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KAISEQ	8	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34134
...YKYICT	20	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30891
...HPWLLS	51	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30892
...LSQSLV	55	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29276
...LSQSLV	55	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30893
...HTANFL	437	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30894
...TANFLL	438	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30895
...ANFLLN	439	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29277
...AQIRTI	583	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30896
...IRTIAI	585	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30897
...AKNQAL	768	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34135
...EHMSM	1091	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	8	ISEQ.\|.QTGK	inferred from experiment	unknown	MEROPS		Merops MMP2_MOUSE -> ACLY_MOUSE @8
CATE_MOUSE	20	YICT.\|.TTSA	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ACLY_MOUSE @20
CATE_MOUSE	51	WLLS.\|.SQSL	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ACLY_MOUSE @51
CATD_MOUSE	55	QSLV.\|.VVKP	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> ACLY_MOUSE @55
CATE_MOUSE	55	QSLV.\|.VVKP	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ACLY_MOUSE @55
CATE_MOUSE	437	ANFL.\|.LLNA	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ACLY_MOUSE @437
CATE_MOUSE	438	NFLL.\|.LNAS	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ACLY_MOUSE @438
CATD_MOUSE	439	FLLN.\|.NASG	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> ACLY_MOUSE @439
CATE_MOUSE	583	IRTI.\|.IAII	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ACLY_MOUSE @583
CATE_MOUSE	585	TIAI.\|.IIAE	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ACLY_MOUSE @585
MMP2_MOUSE	768	NQAL.\|.LKEA	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)