O08788: Dynactin subunit 1
Protein names | - Dynactin subunit 1 - 150 kDa dynein-associated polypeptide - DAP-150 - DP-150 - p150-glued |
---|---|
Gene names | Dctn1 |
Organism | Mus musculus |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | O08788 |
3
N-termini
3
C-termini
2
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MAQSRRHMSS RTPSGSRMST EASARPLRVG SRVEVIGKGH RGTVAYVGAT LFATGKWVGV
70 80 90 100 110 120
ILDEAKGKND GTVQGRKYFT CDEGHGIFVR QSQIQVFEDG ADTTSPETPD SSASKVLKRE
130 140 150 160 170 180
GADAAAKTSK LRGLKPKKAP TARKTTTRRP KPTRPASTGV AGPSSSLGPS GSASAGELSS
190 200 210 220 230 240
SEPSTPAQTP LAAPIIPTPA LTSPGAAPPL PSPSKEEEGL RAQVRDLEEK LETLRLKRSE
250 260 270 280 290 300
DKAKLKELEK HKIQLEQVQE WKSKMQEQQA DLQRRLKEAR KEAKEALEAK ERYMEEMADT
310 320 330 340 350 360
ADAIEMATLD KEMAEERAES LQQEVEALKE RVDELTTDLE ILKAEIEEKG SDGAASSYQL
370 380 390 400 410 420
KQLEEQNARL KDALVRMRDL SSSEKQEHVK LQKLMEKKNQ ELEVVRQQRE RLQEELSQAE
430 440 450 460 470 480
STIDELKEQV DAALGAEEMV EMLTDRNLNL EEKVRELRET VGDLEAMNEM NDELQENARE
490 500 510 520 530 540
TELELREQLD MAGARVREAQ KRVEAAQETV ADYQQTIKKY RQLTAHLQDV NRELTNQQEA
550 560 570 580 590 600
SVERQQQPPP ETFDFKIKFA ETKAHAKAIE MELRQMEVAQ ANRHMSLLTA FMPDSFLRPG
610 620 630 640 650 660
GDHDCVLVLL LMPRLICKAE LIRKQAQEKF DLSENCSERP GLRGAAGEQL SFAAGLVYSL
670 680 690 700 710 720
SLLQATLHRY EHALSQCSVD VYKKVGSLYP EMSAHERSLD FLIELLHKDQ LDETVNVEPL
730 740 750 760 770 780
TKAIKYYQHL YSIHLAEQPE DSTMQLADHI KFTQSALDCM GVEVGRLRAF LQGGQEATDI
790 800 810 820 830 840
ALLLRDLETS CSDTRQFCKK IRRRMPGTDA PGIPAALAFG SQVSDTLLDC RKHLTWVVAV
850 860 870 880 890 900
LQEVAAAAAQ LIAPLAENEG LPVAALEELA FKASEQIYGS PSSSPYECLR QSCTILISTM
910 920 930 940 950 960
NKLATAMQEG EYDAERPPSK PPPVELRAAA LRAEITDAEG LGLKLEDRET VIKELKKSLK
970 980 990 1000 1010 1020
IKGEELSEAN VRLSLLEKKL DSAAKDADER IEKVQTRLDE TQTLLRKKEK DFEETMDALQ
1030 1040 1050 1060 1070 1080
ADIDQLEAEK AELKQRLNSQ SKRTIEGLRG PPPSGIATLV SGIAGEEPQR GGAPGQAPGA
1090 1100 1110 1120 1130 1140
LPGPGLVKDS PLLLQQISAM RLHISQLQHE NSILRGAQMK ASLAALPPLH VAKLSLPPHE
1150 1160 1170 1180 1190 1200
GPGGNLVAGA LYRKTSQLLE KLNQLSTHTH VVDITRSSPA AKSPSAQLME QVAQLKSLSD
1210 1220 1230 1240 1250 1260
TIEKLKDEVL KETVTQRPGA TVPTDFATFP SSAFLRAKEE QQDDTVYMGK VTFSCAAGLG
1270 1280
QRHRLVLTQE QLHQLHSRLI S
Isoforms
- Isoform 2 of Dynactin subunit 1Sequence View
10 20 30 40 50 60
MAQSRRHMSS RTPSGSRMST EASARPLRVG SRVEVIGKGH RGTVAYVGAT LFATGKWVGV
70 80 90 100 110 120
ILDEAKGKND GTVQGRKYFT CDEGHGIFVR QSQIQVFEDG ADTTSPETPD SSASKVLKRE
130 140 150 160 170 180
GADAAAKTSK LRGLKPKKAP TARKTTTRRP KPTRPASTGV AGPSSSLGPS GSASAGELSS
190 200 210 220 230 240
SEPSTPAQTP LAAPIIPTPA LTSPGAAPPL PSPSKEEEGL RAQVRDLEEK LETLRLKRSE
250 260 270 280 290 300
DKAKLKELEK HKIQLEQVQE WKSKMQEQQA DLQRRLKEAR KEAKEALEAK ERYMEEMADT
310 320 330 340 350 360
ADAIEMATLD KEMAEERAES LQQEVEALKE RVDELTTDLE ILKAEIEEKG SDGAASSYQL
370 380 390 400 410 420
KQLEEQNARL KDALVRMRDL SSSEKQEHVK LQKLMEKKNQ ELEVVRQQRE RLQEELSQAE
430 440 450 460 470 480
STIDELKEQV DAALGAEEMV EMLTDRNLNL EEKVRELRET VGDLEAMNEM NDELQENARE
490 500 510 520 530 540
TELELREQLD MAGARVREAQ KRVEAAQETV ADYQQTIKKY RQLTAHLQDV NRELTNQQEA
550 560 570 580 590 600
SVERQQQPPP ETFDFKIKFA ETKAHAKAIE MELRQMEVAQ ANRHMSLLTA FMPDSFLRPG
610 620 630 640 650 660
GDHDCVLVLL LMPRLICKAE LIRKQAQEKF DLSENCSERP GLRGAAGEQL SFAAGLVYSL
670 680 690 700 710 720
SLLQATLHRY EHALSQCSVD VYKKVGSLYP EMSAHERSLD FLIELLHKDQ LDETVNVEPL
730 740 750 760 770 780
TKAIKYYQHL YSIHLAEQPE DSTMQLADHI KFTQSALDCM GVEVGRLRAF LQGGQEATDI
790 800 810 820 830 840
ALLLRDLETS CSDTRQFCKK IRRRMPGTDA PGIPAALAFG SQVSDTLLDC RKHLTWVVAV
850 860 870 880 890 900
LQEVAAAAAQ LIAPLAENEG LPVAALEELA FKASEQIYGS PSSSPYECLR QSCTILISTM
910 920 930 940 950 960
NKLATAMQEG EYDAERPPSK PPPVELRAAA LRAEITDAEG LGLKLEDRET VIKELKKSLK
970 980 990 1000 1010 1020
IKGEELSEAN VRLSLLEKKL DSAAKDADER IEKVQTRLDE TQTLLRKKEK DFEETMDALQ
1030 1040 1050 1060 1070 1080
ADIDQLEAEK AELKQRLNSQ SKRTIEGLRG PPPSGIATLV SGIAGEEPQR GGAPGQAPGA
1090 1100 1110 1120 1130 1140
LPGPGLVKDS PLLLQQISAM RLHISQLQHE NSILRGAQMK ASLAALPPLH VAKLSLPPHE
1150 1160 1170 1180 1190 1200
GPGGNLVAGA LYRKTSQLLE KLNQLSTHTH VVDITRSSPA AKSPSAQLME QVAQLKSLSD
1210 1220 1230 1240 1250 1260
TIEKLKDEVL KETVTQRPGA TVPTDFATFP SSAFLRAKEE QQDDTVYMGK VTFSCAAGLG
1270 1280
QRHRLVLTQE QLHQLHSRLI S
Protein Neighborhood
Domains & Features
3 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
O08788-1-unknown | MAQSRR... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
O08788-1-unknown | MAQSRR... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt72486 | |||
O08788-63-unknown | DEAKGK... | 63 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC28642 | |||
O08788-63-unknown | DEAKGK... | 63 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt140208 | |||
O08788-935-unknown | ITDAEG... | 935 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC33134 | |||
O08788-935-unknown | ITDAEG... | 935 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt157022 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...VGVILD | 62 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC28642 | |||
...VGVILD | 62 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt123322 | |||
...ALRAEI | 934 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC33134 | |||
...ALRAEI | 934 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt140514 | |||
...SRLIS | 1281 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...SRLIS | 1281 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt68104 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
CATD_MOUSE | 62 | VILD.|.DEAK | inferred from experiment | unknown | MEROPS | Merops CATD_MOUSE -> DCTN1_MOUSE @62 | ||
MMP2_MOUSE | 934 | RAEI.|.ITDA | inferred from experiment | unknown | MEROPS | Overall CM | auf dem Keller U et al.:A statistics-based platform for... (M10.003) | 20305283, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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