P70670: Nascent polypeptide-associated complex subunit alpha, muscle-specific form
Protein names | - Nascent polypeptide-associated complex subunit alpha, muscle-specific form - Alpha-NAC, muscle-specific form - skNAC |
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Gene names | Naca |
Organism | Mus musculus |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | P70670 |
10
N-termini
8
C-termini
7
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MPGEATETVP ATEQELPQPQ AETAVLPMSS ALKVAAVGQP GPTPPSSLGP QQSPIVTAHQ
70 80 90 100 110 120
PSPLPSSVSS TPFEVPFAQP ITAETALPSG TAPPTPTFLP HLIGPPISPA ALALASPMIG
130 140 150 160 170 180
LAQKGARSSS APLSLVALAP HSVQKSSVCP PHPLTSPPSA AGAELGALTA SIPPLEPKTS
190 200 210 220 230 240
TSQVPSQGTL NLKGTAPCPP DVVRAFPSHL ENPLASVQPG LMSCPQTLSN TSPVKGVPIS
250 260 270 280 290 300
SALTQSRLSL NLKGPVSPPA RNTAAPSIPL APSTSLGCHL PLLHHSSVDS PIQPPGQSGL
310 320 330 340 350 360
AVSNPTSVGH SGIAASCPPE RCVVPALPSR LLAVDSGAAP SDDKGSSAVT NELCSPPGSS
370 380 390 400 410 420
NVAGTSLSPK ASLVPKGSNV ALQPLVTQVP ASQKTGLKEI PVSCIGATHH ALDNPSAISV
430 440 450 460 470 480
APATHVPPPT SSGLVSSKDP ASPVTSLVVP AAHKQFPAPP ASATLGVPVS PLPATEGLKN
490 500 510 520 530 540
LPISALVNVG APVSPAQAGL PTRKDTTLQP LAPIALKESP SSQSASSLEV LSEDTVTKKT
550 560 570 580 590 600
TGGPAPVVRP AIAGVATTTS LRADSPPAVI RADSCVSPNT VSQPLKRSVT DPAMAPRTAK
610 620 630 640 650 660
NTAPSTTSPL VPLASEGCPV ASSMALSPQN ASVSETALAL SPEIPKSVPF PDPPLAEISF
670 680 690 700 710 720
SNARKVDAVS HMESSGSSRQ GHPDASVTAK GTVVCLADSS LDTSVSASKG SALSGASSPL
730 740 750 760 770 780
YPLEVSFLPE AGLAVQGPKG SLNKLSPTPP SSKGAPVPST GAPPSPKGAP IVPTESSISS
790 800 810 820 830 840
KQVPAEILPS PQKTPEVTAS RLISAVQSPK VDPIMSDVTP TSPKKTSATA VPKDTSATLS
850 860 870 880 890 900
LKSVPAVTSL SPPKAPVAPS NEATIVPTEI PTSLKNALAA ATPKETLATS IPKVTSPSPQ
910 920 930 940 950 960
KTPKSVSLKG APAMTSKKAT EIAASKDVSP SQFPKEVPLL PHVPPTSPPK SPVSDTLSGA
970 980 990 1000 1010 1020
LTSPPPKGPP ATLAETPTYP KKSPKPAASK KTPATPSPEG VTAVPLEIPP CSKKAPKTAA
1030 1040 1050 1060 1070 1080
PKESSATSSS KRAPKTAVSK EIPSKGVTAV PLEISLPLKE TSKSATPGEK SASSPKRSPK
1090 1100 1110 1120 1130 1140
TAGPKETPPG GVTAVPPEIS LPPKETPQNA TPNESLAASS QKRSPKTSVP KETPPGGVTA
1150 1160 1170 1180 1190 1200
MPLEIPSAPQ KAPKTAVPKQ IPTPEDAVTI LAGSPLSPKK ASKTAAPKEA PATPSVGVIA
1210 1220 1230 1240 1250 1260
VSGEISPSPK KTSKTAAPKE NSATLPPKRS PKTAAPKETP ATSSEGVTAV PSEISPSPPT
1270 1280 1290 1300 1310 1320
PASKGVPVTL TPKGAPNALA ESPASPKKVP KTAAPEETST TPSPQKIPKV AGPKEASATP
1330 1340 1350 1360 1370 1380
PSKKTPKTAV PKETSAPSEG VTAVPLEIPP SPRKAPKTAA PKETPAPSPE GATTAPVQIP
1390 1400 1410 1420 1430 1440
PSPRKGSKKA GSKETPTTPS PEGVTAAPLE IPISSKKTSK MASPKETLVT PSSKKLSQTV
1450 1460 1470 1480 1490 1500
GPKETSLEGA TAVPLEIPPS HKKAPKTVDP KQVPLTPSPK DAPTTLAESP SSPKKAPKTA
1510 1520 1530 1540 1550 1560
APPSERVTTV PPEKPATPQK ASATTASKVP VPAETQEVAV SSRETPVTPA VPPVKNPSSH
1570 1580 1590 1600 1610 1620
KKTSKTIELK EAPATLPPSP TKSPKIPSSK KAPRTSAPKE FPASPSIKPV TTSLAQTAPP
1630 1640 1650 1660 1670 1680
SLQKAPSTTI PKENLAAPAV LPVSSKSPAA PAAASASLSP ATAAPQTAPK EATTIPSCKK
1690 1700 1710 1720 1730 1740
AAATETPIET STAPSLEGAP KETSETSVSK VLMSSPPKKA SSSKRASTLP ATTLPSLKEA
1750 1760 1770 1780 1790 1800
SVLSPTATSS GKDSHISPVS DACSTGTTTP QASEKLPSKK GPTAFTEMLA APAPESALAI
1810 1820 1830 1840 1850 1860
TAPIQKSPGA NSNSASSPKC PDPSSKKDTK GLPSAVALAP QTVPVEKDTS KAIETLLVSP
1870 1880 1890 1900 1910 1920
AKGSDCLHSP KGPVGSQVAT PLAAFTSDKV PPEAVSASVA PKPAPAASLT LAPSPVAPLP
1930 1940 1950 1960 1970 1980
PKQPLLESAP GSVLESPSKL PVPAEEDELP PLIPPEAVSG GEPFQPILVN MPAPKPAGTP
1990 2000 2010 2020 2030 2040
APAPSAKQPV LKNNKGSGTE SDSDESVPEL EEQDSTQTAT QQAQLAAAAE IDEEPVSKAK
2050 2060 2070 2080 2090 2100
QSRSEKKARK AMSKLGLRQV TGVTRVTIRK SKNILFVITK PDVYKSPASD TYIVFGEAKI
2110 2120 2130 2140 2150 2160
EDLSQQAQLA AAEKFKVQGE AVSNIQENTQ TPTVQEESEE EEVDETGVEV KDIELVMSQA
2170 2180
NVSRAKAVRA LKNNSNDIVN AIMELTM
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
10 N-termini - 8 C-termini - 7 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P70670-1-unknown | MPGEAT... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P70670-2024-unknown | QLAAAA... | 2024 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC33804 | |||
P70670-2025-unknown | LAAAAE... | 2025 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC33805 | |||
P70670-2026-unknown | AAAAEI... | 2026 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC33806 | |||
P70670-2027-unknown | AAAEID... | 2027 | N-TAILS | Overall CM. | auf dem Keller U.: A statistics-based platform for quantitative N-terminome... | 20305283 | |||
P70670-2027-unmodified | AAAEID... | 2027 | N-TAILS | Overall CM. | Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9... | 20305284 | |||
P70670-2028-unknown | AAEIDE... | 2028 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC30332 | |||
P70670-2031-unknown | IDEEPV... | 2031 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC32396 | |||
P70670-2155-unknown | LVMSQA... | 2155 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC29078 | |||
P70670-2156-unknown | VMSQAN... | 2156 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC29079 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...ATQQAQ | 2023 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC33804 | |||
...TQQAQL | 2024 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC33805 | |||
...QQAQLA | 2025 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC33806 | |||
...AQLAAA | 2027 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC30332 | |||
...AAAAEI | 2030 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC32396 | |||
...VKDIEL | 2154 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC29078 | |||
...KDIELV | 2155 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC29079 | |||
...MELTM | 2187 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
MMP2_MOUSE | 2023 | QQAQ.|.QLAA | inferred from experiment | unknown | MEROPS | Merops MMP2_MOUSE -> NACAM_MOUSE @2023 | ||
MMP2_MOUSE | 2024 | QAQL.|.LAAA | inferred from experiment | unknown | MEROPS | Overall CM | Prudova A et al.:Multiplex N-terminome analysis ... (M10.004) | 20305284, |
MMP2_MOUSE | 2025 | AQLA.|.AAAA | inferred from experiment | unknown | MEROPS | Overall CM | Prudova A et al.:Multiplex N-terminome analysis ... (M10.004) | 20305284, |
CATE_MOUSE | 2027 | LAAA.|.AAEI | inferred from experiment | unknown | MEROPS | Merops CATE_MOUSE -> NACAM_MOUSE @2027 | ||
GRAB_MOUSE | 2030 | AAEI.|.IDEE | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Analysis of protein processing ... (S01.010) | 18836177, |
CATD_MOUSE | 2154 | DIEL.|.LVMS | inferred from experiment | unknown | MEROPS | Merops CATD_MOUSE -> NACAM_MOUSE @2154 | ||
CATD_MOUSE | 2155 | IELV.|.VMSQ | inferred from experiment | unknown | MEROPS | Merops CATD_MOUSE -> NACAM_MOUSE @2155 |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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