Q9JHU4: Cytoplasmic dynein 1 heavy chain 1
Protein names | - Cytoplasmic dynein 1 heavy chain 1 - Cytoplasmic dynein heavy chain 1 - Dynein heavy chain, cytosolic |
---|---|
Gene names | Dync1h1 |
Organism | Mus musculus |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q9JHU4 |
5
N-termini
5
C-termini
4
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MSEPGGGEDG SAGLEVSAVQ NVADVAVLQK HLRKLVPLLL EDGGDAPAAL EAALEEKSAL
70 80 90 100 110 120
EQMRKFLSDP QVHTVLVERS TLKEDVGDEG EEEKEFISYN INIDIHYGVK SNSLAFIKRA
130 140 150 160 170 180
PVIDADKPVS SQLRVLTLSE DSPYETLHSF ISNAVAPFFK SYIRESGKAD RDGDKMAPSV
190 200 210 220 230 240
EKKIAELEMG LLHLQQNIEI PEISLPIHPI ITNVAKQCYE RGEKPKVTDF GDKVEDPTFL
250 260 270 280 290 300
NQLQSGVNRW IREIQKVTKL DRDPASGTAL QEISFWLNLE RALYRIQEKR ESPEVLLTLD
310 320 330 340 350 360
ILKHGKRFHA TVSFDTDTGL KQALETVNDY NPLMKDFPLN DLLSATELDK IRQALVAIFT
370 380 390 400 410 420
HLRKIRNTKY PIQRALRLVE AISRDLSSQL LKVLGTRKLM HVAYEEFEKV MVACFEVFQT
430 440 450 460 470 480
WDDEYEKLQV LLRDIVKRKR EENLKMVWRI NPAHRKLQAR LDQMRKFRRQ HEQLRAVIVR
490 500 510 520 530 540
VLRPQVTAVA QQNQGEAPEP QDMKVAEVLF DAADANAIEE VNLAYENVKE VDGLDVSKEG
550 560 570 580 590 600
TEAWEAAMKR YDERIDRVET RITARLRDQL GTAKNANEMF RIFSRFNALF VRPHIRGAIR
610 620 630 640 650 660
EYQTQLIQRV KDDIESLHDK FKVQYPQSQA CKMSHVRDLP PVSGSIIWAK QIDRQLTAYM
670 680 690 700 710 720
KRVEDVLGKG WENHVEGQKL KQDGDSFRMK LNTQEIFDDW ARKVQQRNLG VSGRIFTIES
730 740 750 760 770 780
ARVRGRTGNV LKLKVNFLPE IITLSKEVRN LKWLGFRVPL AIVNKAHQAN QLYPFAISLI
790 800 810 820 830 840
ESVRTYERTC EKVEERNTIS LLVAGLKKEV QALIAEGIAL VWESYKLDPY VQRLAETVFN
850 860 870 880 890 900
FQEKVDDLLI IEEKIDLEVR SLETCMYDHK TFSEILNRVQ KAVDDLNLHS YSNLPIWVNK
910 920 930 940 950 960
LDMEIERILG VRLQAGLRAW TQVLLGQAED KAEVDMDTDA PQVSHKPGGE PKIKNVVHEL
970 980 990 1000 1010 1020
RITNQVIYLN PPIEECRYKL YQEMFAWKMV VLSLPRIQSQ RYQVGVHYEL TEEEKFYRNA
1030 1040 1050 1060 1070 1080
LTRMPDGPVA LEESYSAVMG IVTEVEQYVK VWLQYQCLWD MQAENIYNRL GEDLNKWQAL
1090 1100 1110 1120 1130 1140
LVQIRKARGT FDNAETKKEF GPVVIDYGKV QSKVNLKYDS WHKEVLSKFG QMLGSNMTEF
1150 1160 1170 1180 1190 1200
HSQISKSRQE LEQHSVDTAS TSDAVTFITY VQSLKRKIKQ FEKQVELYRN GQRLLEKQRF
1210 1220 1230 1240 1250 1260
QFPPSWLYID NIEGEWGAFN DIMRRKDSAI QQQVANLQMK IVQEDRAVES RTTDLLTDWE
1270 1280 1290 1300 1310 1320
KTKPVTGNLR PEEALQALTI YEGKFGRLKD DREKCAKAKE ALELTDTGLL SGSEERVQVA
1330 1340 1350 1360 1370 1380
LEELQDLKGV WSELSKVWEQ IDQMKEQPWV SVQPRKLRQN LDGLLNQLKN FPARLRQYAS
1390 1400 1410 1420 1430 1440
YEFVQRLLKG YMKINMLVIE LKSEALKDRH WKQLMKRLHV NWVVSELTLG QIWDVDLQKN
1450 1460 1470 1480 1490 1500
EAVVKDVLLV AQGEMALEEF LKQIREVWNT YELDLVNYQN KCRLIRGWDD LFNKVKEHIN
1510 1520 1530 1540 1550 1560
SVSAMKLSPY YKVFEEDALS WEDKLNRIMA LFDVWIDVQR RWVYLEGIFT GSADIKHLLP
1570 1580 1590 1600 1610 1620
VETQRFQSIS TEFLALMKKV SKSPLVMDVL NIQGVQRSLE RLADLLGKIQ KALGEYLERE
1630 1640 1650 1660 1670 1680
RSSFPRFYFV GDEDLLEIIG NSKNVAKLQK HFKKMFAGVS SIILNEDNSV VLGISSREGE
1690 1700 1710 1720 1730 1740
EVMFKTPVSI TEHPKINEWL TLVEKEMRVT LAKLLAESVT EVEIFGKATS IDPNTYITWI
1750 1760 1770 1780 1790 1800
DKYQAQLVVL SAQIAWSENV ENALSNVGGG GDVGPLQSVL SNVEVTLNVL ADSVLMEQPP
1810 1820 1830 1840 1850 1860
LRRRKLEHLI TELVHQRDVT RSLIKSKIDN AKSFEWLSQM RFYFDPKQTD VLQQLSIQMA
1870 1880 1890 1900 1910 1920
NAKFNYGFEY LGVQDKLVQT PLTDRCYLTM TQALEARLGG SPFGPAGTGK TESVKALGHQ
1930 1940 1950 1960 1970 1980
LGRFVLVFNC DETFDFQAMG RIFVGLCQVG AWGCFDEFNR LEERMLSAVS QQVQCIQEAL
1990 2000 2010 2020 2030 2040
REHSNPNYDK TSAPITCELL NKQVKVSPDM AIFITMNPGY AGRSNLPDNL KKLFRSLAMT
2050 2060 2070 2080 2090 2100
KPDRQLIAQV MLYSQGFRTA EVLANKIVPF FKLCDEQLSS QSHYDFGLRA LKSVLVSAGN
2110 2120 2130 2140 2150 2160
VKRERIQKIK REKEERGEAV DEGEIAENLP EQEILIQSVC ETMVPKLVAE DIPLLFSLLS
2170 2180 2190 2200 2210 2220
DVFPGVQYHR GEMTALREEL KKVCQEMYLT YGDGEEVGGM WVEKVLQLYQ ITQINHGLMM
2230 2240 2250 2260 2270 2280
VGPSGSGKSM AWRVLLKALE RLEGVEGVAH IIDPKAISKD HLYGTLDPNT REWTDGLFTH
2290 2300 2310 2320 2330 2340
VLRKIIDNVR GELQKRQWIV FDGDVDPEWV ENLNSVLDDN KLLTLPNGER LSLPPNVRIM
2350 2360 2370 2380 2390 2400
FEVQDLKYAT LATVSRCGMV WFSEDVLSTD MIFNNFLARL RSIPLDEGED EAQRRRKGKE
2410 2420 2430 2440 2450 2460
DEGEEAASPM LQIQRDAATI MQPYFTSNGL VTKALEHAFK LEHIMDLTRL RCLGSLFSML
2470 2480 2490 2500 2510 2520
HQACRNVAQY NANHPDFPMQ IEQLERYIQR YLVYAILWSL SGDSRLKMRA ELGEYIRRIT
2530 2540 2550 2560 2570 2580
TVPLPTAPNV PIIDYEVSIS GEWSPWQAKV PQIEVETHKV AAPDVVVPTL DTVRHEALLY
2590 2600 2610 2620 2630 2640
TWLAEHKPLV LCGPPGSGKT MTLFSALRAL PDMEVVGLNF SSATTPELLL KTFDHYCEYR
2650 2660 2670 2680 2690 2700
RTPNGVVLAP VQLGKWLVLF CDEINLPDMD KYGTQRVISF IRQMVEHGGF YRTSDQTWVK
2710 2720 2730 2740 2750 2760
LERIQFVGAC NPPTDPGRKP LSHRFLRHVP VVYVDYPGPA SLTQIYGTFN RAMLRLIPSL
2770 2780 2790 2800 2810 2820
RTYAEPLTAA MVEFYTMSQE RFTQDTQPHY IYSPREMTRW VRGIFEALRP LETLPVEGLI
2830 2840 2850 2860 2870 2880
RIWAHEALRL FQDRLVEDEE RRWTDENIDM VALKHFPNID KEKAMSRPIL YSNWLSKDYI
2890 2900 2910 2920 2930 2940
PVDQEELRDY VKARLKVFYE EELDVPLVLF NEVLDHVLRI DRIFRQPQGH LLLIGVSGAG
2950 2960 2970 2980 2990 3000
KTTLSRFVAW MNGLSVYQIK VHRKYTGEDF DEDLRTVLRR SGCKNEKIAF IMDESNVLDS
3010 3020 3030 3040 3050 3060
GFLERMNTLL ANGEVPGLFE GDEYATLMTQ CKEGAQKEGL MLDSHEELYK WFTSQVIRNL
3070 3080 3090 3100 3110 3120
HVVFTMNPSS EGLKDRAATS PALFNRCVLN WFGDWSTEAL YQVGKEFTSK MDLEKPNYIV
3130 3140 3150 3160 3170 3180
PDYMPVVYDK LPQPPTHREA IVNSCVFVHQ TLHQANARLA KRGGRTMAIT PRHYLDFINH
3190 3200 3210 3220 3230 3240
YANLFHEKRS ELEEQQMHLN VGLRKIKETV DQVEELRRDL RIKSQELEVK NAAANDKLKK
3250 3260 3270 3280 3290 3300
MVKDQQEAEK KKVMSQEIQE QLHKQQEVIA DKQMSVKEDL DKVEPAVIEA QNAVKSIKKQ
3310 3320 3330 3340 3350 3360
HLVEVRSMAN PPAAVKLALE SICLLLGEST TDWKQIRSII MRENFIPTIV NFSAEEISDA
3370 3380 3390 3400 3410 3420
IREKMKKNYM SNPSYNYEIV NRASLACGPM VKWAIAQLNY ADMLKRVEPL RNELQKLEDD
3430 3440 3450 3460 3470 3480
AKDNQQKANE VEQMIRDLEA SIARYKEEYA VLISEAQAIK ADLAAVEAKV NRSTALLKSL
3490 3500 3510 3520 3530 3540
SAERERWEKT SETFKNQMST IAGDCLLSAA FIAYAGYFDQ QMRQNLFTTW SHHLQQANIQ
3550 3560 3570 3580 3590 3600
FRTDIARTEY LSNADERLRW QASSLPADDL CTENAIMLKR FNRYPLIIDP SGQATEFIMN
3610 3620 3630 3640 3650 3660
EYKDRKITRT SFLDDAFRKN LESALRFGNP LLVQDVESYD PVLNPVLNRE VRRTGGRVLI
3670 3680 3690 3700 3710 3720
TLGDQDIDLS PSFVIFLSTR DPTVEFPPDL CSRVTFVNFT VTRSSLQSQC LNEVLKAERP
3730 3740 3750 3760 3770 3780
DVDEKRSDLL KLQGEFQLRL RQLEKSLLQA LNEVKGRILD DDTIITTLEN LKREAAEVTR
3790 3800 3810 3820 3830 3840
KVEETDIVMQ EVETVSQQYL PLSTACSSIY FTMESLKQVH FLYQYSLQFF LDIYHNVLYE
3850 3860 3870 3880 3890 3900
NPNLKGATDH TQRLSIITKD LFQVAFNRVA RGMLHQDHIT FAMLLARIKL KGTVGEPTYD
3910 3920 3930 3940 3950 3960
AEFQHFLRGK EIVLSAGSTP KIQGLTVEQA EAVVRLSCLP AFKDLIAKVQ ADEQFGIWLD
3970 3980 3990 4000 4010 4020
SSSPEQTVPY LWSEETPTTP IGQAIHRLLL IQAFRPDRLL AMAHMFVSTN LGESFMSIME
4030 4040 4050 4060 4070 4080
QPLDLTHIVG TEVKPNTPVL MCSVPGYDAS GHVEDLAAEQ NTQITSIAIG SAEGFNQADK
4090 4100 4110 4120 4130 4140
AINTAVKSGR WVMLKNVHLA PGWLMQLEKK LHSLQPHACF RLFLTMEINP KVPVNLLRAG
4150 4160 4170 4180 4190 4200
RIFVFEPPPG VKANMLRTFS SIPVSRICKS PNERARLYFL LAWFHAIIQE RLRYAPLGWS
4210 4220 4230 4240 4250 4260
KKYEFGESDL RSACDTVDTW LDDTAKGRQN ISPDKIPWSA LKTLMAQSIY GGRVDNEFDQ
4270 4280 4290 4300 4310 4320
RLLNTFLERL FTTRSFDSEF KLACKVDGHK DIQMPDGIRR EEFVQWVELL PDAQTPSWLG
4330 4340 4350 4360 4370 4380
LPNNAERVLL TTQGVDMISK MLKMQMLEDE DDLAYAETEK KARTDSTSDG RPAWMRTLHT
4390 4400 4410 4420 4430 4440
TASNWLHLIP QTLSPLKRTV ENIKDPLFRF FEREVKMGAK LLQDVRQDLA DVVQVCEGKK
4450 4460 4470 4480 4490 4500
KQTNYLRTLI NELVKGILPR SWSHYTVPAG MTVIQWVSDF SERIKQLQNI SQAAASGGAK
4510 4520 4530 4540 4550 4560
ELKNIHVCLG GLFVPEAYIT ATRQYVAQAN SWSLEELCLE VNVTASQSAT LDACSFGVTG
4570 4580 4590 4600 4610 4620
LKLQGATCSN NKLSLSNAIS TVLPLTQLRW VKQTSAEKKA SVVTLPVYLN FTRADLIFTV
4630 4640
DFEIATKEDP RSFYERGVAV LCTE
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
5 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q9JHU4-2-unknown | MSEPGG... | 1 | inferred from similarity | unknown | UniProtKB | inferred from uniprot (by similarity) | |||
Q9JHU4-2-unknown | MSEPGG... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q9JHU4-2-Acetylation | SEPGGG... | 2 | acetylation- | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | ||
Q9JHU4-2-Acetylation | SEPGGG... | 2 | acetylation- | inferred from similarity | unknown | UniProtKB | inferred from uniprot (by similarity) | ||
Q9JHU4-50-unknown | LEAALE... | 50 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC34306 | |||
Q9JHU4-2096-unknown | VSAGNV... | 2096 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC31171 | |||
Q9JHU4-3353-unknown | SAEEIS... | 3353 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC31172 | |||
Q9JHU4-3353-unknown | SAEEIS... | 3353 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC29386 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...DAPAAL | 49 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC34306 | |||
...LKSVLV | 2095 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC31171 | |||
...TIVNFS | 3352 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC31172 | |||
...TIVNFS | 3352 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC29386 | |||
...QCLNEV | 3713 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSMUSP00000126117 | |||
...VLCTE | 4644 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
MMP2_MOUSE | 49 | PAAL.|.LEAA | inferred from experiment | unknown | MEROPS | Overall CM | Prudova A et al.:Multiplex N-terminome analysis ... (M10.004) | 20305284, |
CATE_MOUSE | 2095 | SVLV.|.VSAG | inferred from experiment | unknown | MEROPS | Merops CATE_MOUSE -> DYHC1_MOUSE @2095 | ||
CATE_MOUSE | 3352 | VNFS.|.SAEE | inferred from experiment | unknown | MEROPS | Merops CATE_MOUSE -> DYHC1_MOUSE @3352 | ||
CATD_MOUSE | 3352 | VNFS.|.SAEE | inferred from experiment | unknown | MEROPS | Merops CATD_MOUSE -> DYHC1_MOUSE @3352 |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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