Q9DCL9: Multifunctional protein ADE2

General Information

Protein names	- Multifunctional protein ADE2 - Phosphoribosylaminoimidazole-succinocarboxamide synthase - 6.3.2.6 - SAICAR synthetase - Phosphoribosylaminoimidazole carboxylase - 4.1.1.21 - AIR carboxylase - AIRC
Gene names	Paics
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9DCL9

7 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MATAVVVNIG KKLYEGKTKE VYELLDTPGR VLLQSKDQIT AGNAARKNHL EGKAAISNKI
        70         80         90        100        110        120
TSCIFQLLQE AGIKTAFTKK CGETAFIAPQ CEMIPIEWVC RRIATGSFLK RNPGVQEGYK
       130        140        150        160        170        180
FYPPKVEMFF KDDANNDPQW SEEQLIAAKF CFAGLVIGQT EVDIMSHATQ AIFEILEKSW
       190        200        210        220        230        240
LPQDCTLVDM KIEFGVDVTT KEIVLADVID NDSWRLWPSG DRSQQKDKQS YRDLKEVTPE
       250        260        270        280        290        300
GLQMVKKNFE WVADRVELLL KSDSQCRVVV LMGSTSDLGH CEKIKKACGN FGIPCELRVT
       310        320        330        340        350        360
SAHKGPDETL RIKAEYEGDG IPTVFVSVAG RSNGLGPVLS GNTAYPVISC PPITPDWGAQ
       370        380        390        400        410        420
DVWSSLRLPS GIGCSTILSP EGSAQFAAQI FGLNNHLVWA KLRASILNTW ISLKQADKKV

RQCNL

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

7 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9DCL9-2-unknown	MATAVV...	1		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q9DCL9-2-unknown	MATAVV...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9DCL9-2-Acetylation	ATAVVV...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9DCL9-2-Acetylation	ATAVVV...	2	acetylation-	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q9DCL9-11-unknown	KKLYEG...	11		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q9DCL9-31-unknown	VLLQSK...	31			N-TAILS		Overall CM.	auf dem Keller U.: A statistics-based platform for quantitative N-terminome...	20305283
Q9DCL9-31-unmodified	VLLQSK...	31			N-TAILS		Overall CM.	Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies...	20208520
Q9DCL9-31-unmodified	VLLQSK...	31			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
Q9DCL9-242-unknown	LQMVKK...	242		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34293
Q9DCL9-411-unknown	ISLKQA...	411		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29376

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KKCGET	83	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000117027
...VTPEGL	241	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34293
...ILNTWI	410	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29376
...RQCNL	425	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	241	PEGL.\|.LQMV	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,
CATD_MOUSE	410	NTWI.\|.ISLK	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> PUR6_MOUSE @410

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)