P63017: Heat shock cognate 71 kDa protein

General Information

Protein names	- Heat shock cognate 71 kDa protein - Heat shock 70 kDa protein 8
Gene names	Hspa8
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P63017

39 N-termini

21 C-termini

25 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSKGPAVGID LGTTYSCVGV FQHGKVEIIA NDQGNRTTPS YVAFTDTERL IGDAAKNQVA
        70         80         90        100        110        120
MNPTNTVFDA KRLIGRRFDD AVVQSDMKHW PFMVVNDAGR PKVQVEYKGE TKSFYPEEVS
       130        140        150        160        170        180
SMVLTKMKEI AEAYLGKTVT NAVVTVPAYF NDSQRQATKD AGTIAGLNVL RIINEPTAAA
       190        200        210        220        230        240
IAYGLDKKVG AERNVLIFDL GGGTFDVSIL TIEDGIFEVK STAGDTHLGG EDFDNRMVNH
       250        260        270        280        290        300
FIAEFKRKHK KDISENKRAV RRLRTACERA KRTLSSSTQA SIEIDSLYEG IDFYTSITRA
       310        320        330        340        350        360
RFEELNADLF RGTLDPVEKA LRDAKLDKSQ IHDIVLVGGS TRIPKIQKLL QDFFNGKELN
       370        380        390        400        410        420
KSINPDEAVA YGAAVQAAIL SGDKSENVQD LLLLDVTPLS LGIETAGGVM TVLIKRNTTI
       430        440        450        460        470        480
PTKQTQTFTT YSDNQPGVLI QVYEGERAMT KDNNLLGKFE LTGIPPAPRG VPQIEVTFDI
       490        500        510        520        530        540
DANGILNVSA VDKSTGKENK ITITNDKGRL SKEDIERMVQ EAEKYKAEDE KQRDKVSSKN
       550        560        570        580        590        600
SLESYAFNMK ATVEDEKLQG KINDEDKQKI LDKCNEIISW LDKNQTAEKE EFEHQQKELE
       610        620        630        640
KVCNPIITKL YQSAGGMPGG MPGGFPGGGA PPSGGASSGP TIEEVD

Isoforms

Sequence View

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Physiological Relevance:

Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

39 N-termini - 21 C-termini - 25 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P63017-2-unknown	MSKGPA...	1		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P63017-2-unknown	MSKGPA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P63017-2-Acetylation	SKGPAV...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P63017-2-Acetylation	SKGPAV...	2	acetylation-		N-TAILS		Overall CM.	Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies...	20208520
P63017-2-Acetylation	SKGPAV...	2	acetylation-	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P63017-13-unknown	TTYSCV...	13		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P63017-14-unknown	TYSCVG...	14		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33715
P63017-20-unknown	VFQHGK...	20		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33716
P63017-26-unknown	VEIIAN...	26		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33717
P63017-28-unknown	IIANDQ...	28		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30220
P63017-28-unknown	IIANDQ...	28		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33718
P63017-41-unknown	YVAFTD...	41		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33719
P63017-42-unknown	VAFTDT...	42		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30221
P63017-42-unknown	VAFTDT...	42		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33720
P63017-51-unmodified	IGDAAK...	51			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P63017-51-unknown	IGDAAK...	51		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30222
P63017-51-unknown	IGDAAK...	51		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29012
P63017-57-unknown	NQVAMN...	57			N-TAILS		Overall CM.	auf dem Keller U.: A statistics-based platform for quantitative N-terminome...	20305283
P63017-58-unknown	QVAMNP...	58		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33721
P63017-59-unknown	VAMNPT...	59		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30223
P63017-87-unknown	MKHWPF...	87		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33722
P63017-89-unknown	HWPFMV...	89		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P63017-92-unknown	FMVVND...	92		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33723
P63017-133-unknown	AYLGKT...	133		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30224
P63017-133-unknown	AYLGKT...	133		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33724
P63017-134-unknown	YLGKTV...	134		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33725
P63017-142-unknown	AVVTVP...	142		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30225
P63017-142-unknown	AVVTVP...	142		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29013
P63017-143-unknown	VVTVPA...	143		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30226
P63017-143-unknown	VVTVPA...	143		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29014
P63017-156-Pyrrolidone carboxylic acid	QATKDA...	156	pyrrolidone carboxylic acid-		unknown			Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
P63017-156-acetylation	QATKDA...	156	acetylation-		N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P63017-158-unmodified	TKDAGT...	158			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P63017-172-unmodified	IINEPT...	172			N-TAILS		Overall CM.	Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies...	20208520
P63017-173-unmodified	INEPTA...	173			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P63017-178-unmodified	AAAIAY...	178			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P63017-181-unknown	IAYGLD...	181		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33726
P63017-182-unknown	AYGLDK...	182			N-TAILS		Overall CM.	auf dem Keller U.: A statistics-based platform for quantitative N-terminome...	20305283
P63017-219-unknown	VKSTAG...	219		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33727
P63017-221-unmodified	STAGDT...	221			N-TAILS		Overall CM.	Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies...	20208520
P63017-221-unmodified	STAGDT...	221			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P63017-223-unknown	AGDTHL...	223			N-TAILS		Overall CM.	auf dem Keller U.: A statistics-based platform for quantitative N-terminome...	20305283
P63017-224-unknown	GDTHLG...	224			N-TAILS		Overall CM.	auf dem Keller U.: A statistics-based platform for quantitative N-terminome...	20305283
P63017-238-unmodified	VNHFIA...	238			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P63017-305-unknown	LNADLF...	305		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33728
P63017-312-unmodified	GTLDPV...	312			N-TAILS		Overall CM.	Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies...	20208520
P63017-324-unknown	AKLDKS...	324			N-TAILS		Overall CM.	auf dem Keller U.: A statistics-based platform for quantitative N-terminome...	20305283
P63017-329-unmodified	SQIHDI...	329			N-TAILS		Overall CM.	Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies...	20208520
P63017-440-unknown	IQVYEG...	440		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29015

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IDLGTT	13	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33715
...YSCVGV	19	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33716
...FQHGKV	25	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33717
...HGKVEI	27	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30220
...HGKVEI	27	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33718
...RTTPSY	40	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33719
...TTPSYV	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30221
...TTPSYV	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33720
...DTERLI	50	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30222
...DTERLI	50	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29012
...DAAKNQ	57	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33721
...AAKNQV	58	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30223
...VVQSDM	86	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33722
...MKHWPF	91	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33723
...KSFYPE	116	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000117285
...KEIAEA	132	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30224
...KEIAEA	132	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33724
...EIAEAY	133	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33725
...KTVTNA	141	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30225
...KTVTNA	141	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29013
...TVTNAV	142	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30226
...TVTNAV	142	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29014
...PTAAAI	180	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33726
...DGIFEV	218	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33727
...ARFEEL	304	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33728
...QPGVLI	439	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29015
...IEEVD	646	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	13	LGTT.\|.TYSC	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	19	CVGV.\|.VFQH	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	25	HGKV.\|.VEII	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATE_MOUSE	27	KVEI.\|.IIAN	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> HSP7C_MOUSE @27
MMP2_MOUSE	27	KVEI.\|.IIAN	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	40	TPSY.\|.YVAF	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATE_MOUSE	41	PSYV.\|.VAFT	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> HSP7C_MOUSE @41
MMP2_MOUSE	41	PSYV.\|.VAFT	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATE_MOUSE	50	ERLI.\|.IGDA	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> HSP7C_MOUSE @50
CATD_MOUSE	50	ERLI.\|.IGDA	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> HSP7C_MOUSE @50
MMP2_MOUSE	57	AKNQ.\|.QVAM	inferred from experiment	unknown	MEROPS		Merops MMP2_MOUSE -> HSP7C_MOUSE @57
CATE_MOUSE	58	KNQV.\|.VAMN	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> HSP7C_MOUSE @58
MMP2_MOUSE	86	QSDM.\|.MKHW	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	91	HWPF.\|.FMVV	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATE_MOUSE	132	IAEA.\|.AYLG	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> HSP7C_MOUSE @132
MMP2_MOUSE	132	IAEA.\|.AYLG	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	133	AEAY.\|.YLGK	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,
CATE_MOUSE	141	VTNA.\|.AVVT	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> HSP7C_MOUSE @141
CATD_MOUSE	141	VTNA.\|.AVVT	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> HSP7C_MOUSE @141
CATE_MOUSE	142	TNAV.\|.VVTV	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> HSP7C_MOUSE @142
CATD_MOUSE	142	TNAV.\|.VVTV	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> HSP7C_MOUSE @142
MMP2_MOUSE	180	AAAI.\|.IAYG	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	218	IFEV.\|.VKST	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	304	FEEL.\|.LNAD	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATD_MOUSE	439	GVLI.\|.IQVY	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> HSP7C_MOUSE @439

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)