Q7TQI3: Ubiquitin thioesterase OTUB1

General Information

Protein names	- Ubiquitin thioesterase OTUB1 - 3.4.19.12 {ECO:0000250\|UniProtKB:Q96FW1} - Deubiquitinating enzyme OTUB1 - OTU domain-containing ubiquitin aldehyde-binding protein 1 - Otubain-1 - Ubiquitin-specific-processing protease OTUB1
Gene names	Otub1
Organism	Mus musculus
Protease Family
Protease ID	C65.001
Chromosome location
UniProt ID	Q7TQI3

7 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAEEPQQQK QEPLGSDSEG VNCLAYDEAI MAQQDRIQQE IAVQNPLVSE RLELSVLYKE
        70         80         90        100        110        120
YAEDDNIYQQ KIKDLHKKYS YIRKTRPDGN CFYRAFGFSH LEALLDDSKE LQRFKAVSAK
       130        140        150        160        170        180
SKEDLVSQGF TEFTIEDFHN TFMDLIEQVE KQTSVADLLA SFNDQSTSDY LVVYLRLLTS
       190        200        210        220        230        240
GYLQRESKFF EHFIEGGRTV KEFCQQEVEP MCKESDHIHI IALAQALSVS IQVEYMDRGE
       250        260        270
GGTTNPHVFP EGSEPKVYLL YRPGHYDILY K

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

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Protein Neighborhood

Domains & Features

7 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
Q7TQI3-2-unknown	MAAEEP...	1		inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
Q7TQI3-2-unknown	MAAEEP...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q7TQI3-2-Acetylation	AAEEPQ...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q7TQI3-2-Acetylation	AAEEPQ...	2	acetylation-	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
Q7TQI3-28-unknown	EAIMAQ...	28		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32496
Q7TQI3-31-unknown	MAQQDR...	31		inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000115195
Q7TQI3-31-unknown	MAQQDR...	31		inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000122945
Q7TQI3-41-unknown	IAVQNP...	41		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30683
Q7TQI3-70-unknown	QKIKDL...	70		inferred from electronic annotation	unknown	TISdb	inferred from TISdb
Q7TQI3-105-unknown	LDDSKE...	105		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29221
Q7TQI3-105-unknown	LDDSKE...	105		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30684

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...CLAYDE	27	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32496
...RIQQEI	40	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30683
...HLEALL	104	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29221
...HLEALL	104	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30684
...SKEDLV	125	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000122945
...DILYK	271	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_MOUSE	27	AYDE.\|.EAIM	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CATE_MOUSE	40	QQEI.\|.IAVQ	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> OTUB1_MOUSE @40
CATD_MOUSE	104	EALL.\|.LDDS	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> OTUB1_MOUSE @104
CATE_MOUSE	104	EALL.\|.LDDS	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> OTUB1_MOUSE @104

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)