P57780: Alpha-actinin-4 {ECO:0000305}

General Information

Protein names	- Alpha-actinin-4 {ECO:0000305} - Non-muscle alpha-actinin 4 {ECO:0000305}
Gene names	Actn4
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P57780

11 N-termini

9 C-termini

6 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MVDYHAANQA YQYGPNSGGG NGAGGGGSMG DYMAQEDDWD RDLLLDPAWE KQQRKTFTAW
        70         80         90        100        110        120
CNSHLRKAGT QIENIDEDFR DGLKLMLLLE VISGERLPKP ERGKMRVHKI NNVNKALDFI
       130        140        150        160        170        180
ASKGVKLVSI GAEEIVDGNA KMTLGMIWTI ILRFAIQDIS VEETSAKEGL LLWCQRKTAP
       190        200        210        220        230        240
YKNVNVQNFH ISWKDGLAFN ALIHRHRPEL IEYDKLRKDD PVTNLNNAFE VAEKYLDIPK
       250        260        270        280        290        300
MLDAEDIVNT ARPDEKAIMT YVSSFYHAFS GAQKAETAAN RICKVLAVNQ ENEHLMEDYE
       310        320        330        340        350        360
RLASDLLEWI RRTIPWLEDR VPQKTIQEMQ QKLEDFRDYR RVHKPPKVQE KCQLEINFNT
       370        380        390        400        410        420
LQTKLRLSNR PAFMPSEGRM VSDINNGWQH LEQAEKGYEE WLLNEIRRLE RLDHLAEKFR
       430        440        450        460        470        480
QKASIHEAWT DGKEAMLKQR DYETATLSDI KALIRKHEAF ESDLAAHQDR VEQIAAIAQE
       490        500        510        520        530        540
LNELDYYDSH NVNTRCQKIC DQWDNLGSLT HSRREALEKT EKQLETIDQL HLEYAKRAAP
       550        560        570        580        590        600
FNNWMESAME DLQDMFIVHT IEEIEGLISA HDQFKSTLPD ADREREAILA IHKEAQRIAE
       610        620        630        640        650        660
SNHIKLSGSN PYTTVTPQII NSKWEKVQQL VPKRDHALLE EQSKQQSNEH LRRQFASQAN
       670        680        690        700        710        720
MVGPWIQTKM EEIGRISIEM NGTLEDQLSH LKQYERSIVD YKPSLDLLEQ QHQLIQEALI
       730        740        750        760        770        780
FDNKHTNYTM EHIRVGWEQL LTTIARTINE VENQILTRDA KGISQEQMQE FRASFNHFDK
       790        800        810        820        830        840
DHGGALGPEE FKACLISLGY DVENDRQGDA EFNRIMSVVD PNHSGLVTFQ AFIDFMSRET
       850        860        870        880        890        900
TDTDTADQVI ASFKVLAGDK NFITAEELRR ELPPDQAEYC IARMAPYQGP DAAPGALDYK
       910
SFSTALYGES DL

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

11 N-termini - 9 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P57780-1-unknown	MVDYHA...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P57780-32-unknown	YMAQED...	32	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33636
P57780-86-unknown	MLLLEV...	86	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSMUSP00000123210
P57780-86-unknown	MLLLEV...	86	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSMUSP00000122268
P57780-181-unknown	YKNVNV...	181	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P57780-270-unmodified	SGAQKA...	270		N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P57780-272-unknown	AQKAET...	272	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30108
P57780-285-unknown	VLAVNQ...	285	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33637
P57780-353-unmodified	QLEINF...	353		N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P57780-355-unknown	EINFNT...	355	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30109
P57780-359-unknown	NTLQTK...	359	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC28944
P57780-359-unknown	NTLQTK...	359	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30110
P57780-496-5oxothiomorpholine-3-carboxylic-acid	CQKICD...	496		N-TAILS		Overall CM.	Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies...	20208520

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GSMGDY	31	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33636
...DKLRKD	218	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000122268
...HAFSGA	271	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30108
...NRICKV	284	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33637
...AVNQEN	291	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000123210
...EKCQLE	354	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30109
...LEINFN	358	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28944
...LEINFN	358	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30110
...REALEK	518	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000115436
...GESDL	912	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	31	MGDY.\|.YMAQ	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATE_MOUSE	271	FSGA.\|.AQKA	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ACTN4_MOUSE @271
MMP2_MOUSE	284	ICKV.\|.VLAV	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATE_MOUSE	354	CQLE.\|.EINF	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ACTN4_MOUSE @354
CATD_MOUSE	358	INFN.\|.NTLQ	inferred from experiment	unknown	MEROPS	Zornig M	Melzer IM et al.:The Apaf-1-binding protein Aven... (A01.009)	22388353,
CATE_MOUSE	358	INFN.\|.NTLQ	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ACTN4_MOUSE @358

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)