Q99LI8: Hepatocyte growth factor-regulated tyrosine kinase substrate

General Information

Protein names	- Hepatocyte growth factor-regulated tyrosine kinase substrate
Gene names	Hgs
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q99LI8

7 N-termini

6 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGRGSGTFER LLDKATSQLL LETDWESILQ ICDLIRQGDT QAKYAVNSIK KKVNDKNPHV
        70         80         90        100        110        120
ALYALEVMES VVKNCGQTVH DEVANKQTME ELKELLKRQV EVNVRNKILY LIQAWAHAFR
       130        140        150        160        170        180
NEPKYKVVQD TYQIMKVEGH VFPEFKESDA MFAAERAPDW VDAEECHRCR VQFGVVTRKH
       190        200        210        220        230        240
HCRACGQIFC GKCSSKYSTI PKFGIEKEVR VCEPCYEQLN KKAEGKASST TELPPEYLTS
       250        260        270        280        290        300
PLSQQSQLPP KRDETALQEE EELQLALALS QSEAEEKERM RQKTTYTAHP KAEPTPLASS
       310        320        330        340        350        360
APPAGSLYSS PVNSSAPLAE DIDPELARYL NRNYWEKKQE EARKSPTPSA PVPLTEPAAQ
       370        380        390        400        410        420
PGEGHTAPNS MAEAPLPETD SQPITPCSGP FSEYQNGESE ESHEQFLKAL QNAVSTFVNR
       430        440        450        460        470        480
MKSNHMRGRS ITNDSAVLSL FQSINTMHPQ LLELLNQLDE RRLYYEGLQD KLAQIRDARG
       490        500        510        520        530        540
ALSALREEHR EKLRRAAEEA ERQRQIQLAQ KLEIMRQKKQ EYLEVQRQLA IQRLQEQEKE
       550        560        570        580        590        600
RQMRLEQQKQ TVQMRAQMPA FPLPYAQLQA MPTAGGVLYQ PSGPTSFPAT FSPAGSVEGS
       610        620        630        640        650        660
PMHGVYMSQP APATGPYPSM PGTTADPSMV SAYMYPTGAP GAQAAPQAQA GPTTSPAYSS
       670        680        690        700        710        720
YQPTPTPGYQ SVASQAPQSL PAISQPPQTS NIGYMGSQPM SMGYQPYNMQ NLMTALPGQD
       730        740        750        760        770
ASLPAQQPYI PGQQPLYQQM APSTGPPQQQ PPVAQPAPTQ GPPAQGSEAQ LISFD

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 6 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q99LI8-1-unknown	MGRGSG...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q99LI8-56-unknown	KNPHVA...	56	inferred from electronic annotation	unknown	TISdb	inferred from TISdb
Q99LI8-266-unknown	ALALSQ...	266	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30983
Q99LI8-267-unknown	LALSQS...	267	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29312
Q99LI8-268-unknown	ALSQSE...	268	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30984
Q99LI8-269-unknown	LSQSEA...	269	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34172
Q99LI8-314-unknown	SSAPLA...	314	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34173

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EELQLA	265	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30983
...ELQLAL	266	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29312
...LQLALA	267	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30984
...QLALAL	268	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34172
...SSPVNS	313	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34173
...LISFD	775	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATE_MOUSE	265	LQLA.\|.ALAL	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> HGS_MOUSE @265
CATD_MOUSE	266	QLAL.\|.LALS	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> HGS_MOUSE @266
CATE_MOUSE	267	LALA.\|.ALSQ	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> HGS_MOUSE @267
MMP2_MOUSE	268	ALAL.\|.LSQS	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	313	PVNS.\|.SSAP	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)