Q91VC3: Eukaryotic initiation factor 4A-III

General Information

Protein names	- Eukaryotic initiation factor 4A-III - eIF-4A-III - eIF4A-III - 3.6.4.13 {ECO:0000250\|UniProtKB:P38919} - ATP-dependent RNA helicase DDX48 - ATP-dependent RNA helicase eIF4A-3 - DEAD box protein 48 - Eukaryotic translation initiation factor 4A isoform 3 - Eukaryotic initiation factor 4A-III, N-terminally processed
Gene names	Eif4a3
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q91VC3

5 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAANATMATS GSARKRLLKE EDMTKVEFET SEEVDVTPTF DTMGLREDLL RGIYAYGFEK
        70         80         90        100        110        120
PSAIQQRAIK QIIKGRDVIA QSQSGTGKTA TFSVSVLQCL DIQVRETQAL ILAPTRELAV
       130        140        150        160        170        180
QIQKGLLALG DYMNVQCHAC IGGTNVGEDI RKLDYGQHVV AGTPGRVFDM IRRRSLRTRA
       190        200        210        220        230        240
IKMLVLDEAD EMLNKGFKEQ IYDVYRYLPP ATQVVLISAT LPHEILEMTN KFMTDPIRIL
       250        260        270        280        290        300
VKRDELTLEG IKQFFVAVER EEWKFDTLCD LYDTLTITQA VIFCNTKRKV DWLTEKMREA
       310        320        330        340        350        360
NFTVSSMHGD MPQKERESIM KEFRSGASRV LISTDVWARG LDVPQVSLII NYDLPNNREL
       370        380        390        400        410
YIHRIGRSGR YGRKGVAINF VKNDDIRILR DIEQYYSTQI DEMPMNVADL I

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q91VC3-1-Acetylation	MAANAT...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q91VC3-2-Acetylation	AANATM...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q91VC3-2-Acetylation	AANATM...	2	acetylation-	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q91VC3-7-unknown	MATSGS...	7		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q91VC3-55-unknown	AYGFEK...	55		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29278
Q91VC3-196-unmodified	GFKEQI...	196			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LRGIYA	54	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29278
...RESIMK	320	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000101860
...VADLI	411	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATD_MOUSE	54	GIYA.\|.AYGF	inferred from experiment	unknown	MEROPS	Zornig M	Melzer IM et al.:The Apaf-1-binding protein Aven... (A01.009)	22388353,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)