Q61753: D-3-phosphoglycerate dehydrogenase

General Information

Protein names	- D-3-phosphoglycerate dehydrogenase - 3-PGDH - 1.1.1.95 {ECO:0000250\|UniProtKB:O08651} - A10
Gene names	Phgdh
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q61753

6 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAFANLRKVL ISDSLDPCCR KILQDGGLQV VEKQNLSKEE LIAELQDCEG LIVRSATKVT
        70         80         90        100        110        120
ADVINAAEKL QVVGRAGTGV DNVDLEAATR KGILVMNTPN GNSLSAAELT CGMIMCLARQ
       130        140        150        160        170        180
IPQATASMKD GKWDRKKFMG TELNGKTLGI LGLGRIGREV ATRMQSFGMK TVGYDPIISP
       190        200        210        220        230        240
EVAASFGVQQ LPLEEIWPLC DFITVHTPLL PSTTGLLNDS TFAQCKKGVR VVNCARGGIV
       250        260        270        280        290        300
DEGALLRALQ SGQCAGAALD VFTEEPPRDR ALVDHENVIS CPHLGASTKE AQSRCGEEIA
       310        320        330        340        350        360
VQFVDMVKGK SLTGVVNAQA LTSAFSPHTK PWIGLAEAMG TLMHAWAGSP KGTIQVVTQG
       370        380        390        400        410        420
TSLKNAGTCL SPAVIVGLLR EASKQADVNL VNAKLLVKEA GLNVTTSHNP GVPGEQGSGE
       430        440        450        460        470        480
CLLTVALAGA PYQAVGLVQG TTPMLQMLNG AVFRPEVPLR RGQPLLVFRA QPSDPGMLPT
       490        500        510        520        530
MIGLLAEAGV QLLSYQTSMV SDGEPWHVMG LSSLLPSLET WKQHVLEAFQ FCF

Isoforms

Sequence View

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Evidence Codes:

Methodology:

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Evidence Names:

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Protein Neighborhood

Domains & Features

6 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q61753-2-unknown	MAFANL...	1		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q61753-2-unknown	MAFANL...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q61753-2-Acetylation	AFANLR...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q61753-2-Acetylation	AFANLR...	2	acetylation-	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q61753-11-unknown	ISDSLD...	11		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30530
Q61753-11-unknown	ISDSLD...	11		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29167
Q61753-45-unknown	LQDCEG...	45		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33961
Q61753-223-unknown	AQCKKG...	223		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29168
Q61753-271-unmodified	ALVDHE...	271			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LRKVLI	10	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30530
...LRKVLI	10	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29167
...ELIAEL	44	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33961
...GYDPII	177	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000117525
...NDSTFA	222	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29168
...FQFCF	533	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATE_MOUSE	10	KVLI.\|.ISDS	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> SERA_MOUSE @10
CATD_MOUSE	10	KVLI.\|.ISDS	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> SERA_MOUSE @10
MMP2_MOUSE	44	IAEL.\|.LQDC	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATD_MOUSE	222	STFA.\|.AQCK	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> SERA_MOUSE @222

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)