Q9QZQ8: Core histone macro-H2A.1

General Information

Protein names	- Core histone macro-H2A.1 - Histone macroH2A1 - mH2A1 - H2A.y - H2A/y
Gene names	H2afy
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9QZQ8

7 N-termini

6 C-termini

7 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSSRGGKKKS TKTSRSAKAG VIFPVGRMLR YIKKGHPKYR IGVGAPVYMA AVLEYLTAEI
        70         80         90        100        110        120
LELAGNAARD NKKGRVTPRH ILLAVANDEE LNQLLKGVTI ASGGVLPNIH PELLAKKRGS
       130        140        150        160        170        180
KGKLEAIITP PPAKKAKSPS QKKPVAKKTG GKKGARKSKK KQGEVSKAAS ADSTTEGTPT
       190        200        210        220        230        240
DGFTVLSTKS LFLGQKLNLI HSEISNLAGF EVEAIINPTN ADIDLKDDLG NTLEKKGGKE
       250        260        270        280        290        300
FVEAVLELRK KNGPLEVAGA AISAGHGLPA KFVIHCNSPV WGADKCEELL EKTVKNCLAL
       310        320        330        340        350        360
ADDRKLKSIA FPSIGSGRNG FPKQTAAQLI LKAISSYFVS TMSSSIKTVY FMLFDSESIG
       370
IYVQEMAKLD AN

Isoforms

- Isoform 1 of Core histone macro-H2A.1

Sequence View

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Protein Neighborhood

Domains & Features

7 N-termini - 6 C-termini - 7 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
Q9QZQ8-1-unknown	MSSRGG...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9QZQ8-1-unknown	MSSRGG...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt76698
Q9QZQ8-55-unknown	YLTAEI...	55	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31291
Q9QZQ8-55-unknown	YLTAEI...	55	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139516
Q9QZQ8-57-unknown	TAEILE...	57	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31293
Q9QZQ8-57-unknown	TAEILE...	57	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29416
Q9QZQ8-57-unknown	TAEILE...	57	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139666
Q9QZQ8-57-unmodified	TAEILE...	57		unknown		Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
Q9QZQ8-59-unknown	EILELA...	59	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29418
Q9QZQ8-59-unknown	EILELA...	59	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139861
Q9QZQ8-60-unknown	ILELAG...	60	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31295
Q9QZQ8-60-unknown	ILELAG...	60	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29420
Q9QZQ8-60-unknown	ILELAG...	60	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139899
Q9QZQ8-62-unknown	ELAGNA...	62	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29422
Q9QZQ8-62-unknown	ELAGNA...	62	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt140130

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AAVLEY	54	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31291
...AAVLEY	54	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122606
...VLEYLT	56	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31293
...VLEYLT	56	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29416
...VLEYLT	56	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122762
...EYLTAE	58	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29418
...EYLTAE	58	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122961
...YLTAEI	59	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31295
...YLTAEI	59	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29420
...YLTAEI	59	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123004
...TAEILE	61	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29422
...TAEILE	61	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123238
...KLDAN	372	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KLDAN	372	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72316

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATE_MOUSE	54	VLEY.\|.YLTA	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> H2AY_MOUSE @54
CATE_MOUSE	56	EYLT.\|.TAEI	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> H2AY_MOUSE @56
CATD_MOUSE	56	EYLT.\|.TAEI	inferred from experiment	unknown	MEROPS	Zornig M	Melzer IM et al.:The Apaf-1-binding protein Aven... (A01.009)	22388353,
CATD_MOUSE	58	LTAE.\|.EILE	inferred from experiment	unknown	MEROPS	Zornig M	Melzer IM et al.:The Apaf-1-binding protein Aven... (A01.009)	22388353,
CATE_MOUSE	59	TAEI.\|.ILEL	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> H2AY_MOUSE @59
CATD_MOUSE	59	TAEI.\|.ILEL	inferred from experiment	unknown	MEROPS	Zornig M	Melzer IM et al.:The Apaf-1-binding protein Aven... (A01.009)	22388353,
CATD_MOUSE	61	EILE.\|.ELAG	inferred from experiment	unknown	MEROPS	Zornig M	Melzer IM et al.:The Apaf-1-binding protein Aven... (A01.009)	22388353,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)