P18654: Ribosomal protein S6 kinase alpha-3

General Information

Protein names	- Ribosomal protein S6 kinase alpha-3 - S6K-alpha-3 - 2.7.11.1 {ECO:0000250\|UniProtKB:P51812} - 90 kDa ribosomal protein S6 kinase 3 - p90-RSK 3 - p90RSK3 - MAP kinase-activated protein kinase 1b - MAPK-activated protein kinase 1b - MAPKAP kinase 1b - MAPKAPK-1b - Ribosomal S6 kinase 2 - RSK-2 - pp90RSK2
Gene names	Rps6ka3
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P18654

4 N-termini

7 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPLAQLADPW QKMAVESPSD SAENGQQIMD EPMGEEEINP QTEEGSIKEI AITHHVKEGH
        70         80         90        100        110        120
EKADPSQFEL LKVLGQGSFG KVFLVKKISG SDARQLYAMK VLKKATLKVR DRVRTKMERD
       130        140        150        160        170        180
ILVEVNHPFI VKLHYAFQTE GKLYLILDFL RGGDLFTRLS KEVMFTEEDV KFYLAELALA
       190        200        210        220        230        240
LDHLHSLGII YRDLKPENIL LDEEGHIKLT DFGLSKESID HEKKAYSFCG TVEYMAPEVV
       250        260        270        280        290        300
NRRGHTQSAD WWSFGVLMFE MLTGTLPFQG KDRKETMTMI LKAKLGMPQF LSPEAQSLLR
       310        320        330        340        350        360
MLFKRNPANR LGAGPDGVEE IKRHSFFSTI DWNKLYRREI HPPFKPATGR PEDTFYFDPE
       370        380        390        400        410        420
FTAKTPKDSP GIPPSANAHQ LFRGFSFVAI TSDDESQAMQ TVGVHSIVQQ LHRNSIQFTD
       430        440        450        460        470        480
GYEVKEDIGV GSYSVCKRCI HKATNMEFAV KIIDKSKRDP TEEIEILLRY GQHPNIITLK
       490        500        510        520        530        540
DVYDDGKYVY VVTELMKGGE LLDKILRQKF FSEREASAVL FTITKTVEYL HAQGVVHRDL
       550        560        570        580        590        600
KPSNILYVDE SGNPESIRIC DFGFAKQLRA ENGLLMTPCY TANFVAPEVL KRQGYDAACD
       610        620        630        640        650        660
IWSLGVLLYT MLTGYTPFAN GPDDTPEEIL ARIGSGKFSL SGGYWNSVSD TAKDLVSKML
       670        680        690        700        710        720
HVDPHQRLTA ALVLRHPWIV HWDQLPQYQL NRQDAPHLVK GAMAATYSAL NRNQSPVLEP
       730        740
VGRSTLAQRR GIKKITSTAL

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 7 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P18654-1-unknown	MPLAQL...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P18654-3-unknown	LAQLAD...	3	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000123059
P18654-29-unknown	MDEPMG...	29	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000108112
P18654-29-unknown	MDEPMG...	29	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000118007
P18654-29-unknown	MDEPMG...	29	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000108111
P18654-84-unknown	LVKKIS...	84	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29818
P18654-84-unknown	LVKKIS...	84	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28814

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EGHEKA	62	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000118007
...FGKVFL	83	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29818
...FGKVFL	83	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28814
...TKMERD	119	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000115271
...LSKEVM	163	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000108111
...IIYRDL	193	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000123059
...APEVVN	240	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000108110
...TSTAL	740	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATE_MOUSE	83	KVFL.\|.LVKK	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> KS6A3_MOUSE @83
CATD_MOUSE	83	KVFL.\|.LVKK	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> KS6A3_MOUSE @83

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)