O88990: Alpha-actinin-3

General Information

Protein names	- Alpha-actinin-3 - Alpha-actinin skeletal muscle isoform 3 - F-actin cross-linking protein
Gene names	Actn3
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	O88990

4 N-termini

4 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MMMVMQPEGL GAGEGPFSGG GGGEYMEQEE DWDRDLLLDP AWEKQQRKTF TAWCNSHLRK
        70         80         90        100        110        120
AGTQIENIEE DFRNGLKLML LLEVISGERL PRPDKGKMRF HKIANVNKAL DFIASKGVKL
       130        140        150        160        170        180
VSIGAEEIVD GNLKMTLGMI WTIILRFAIQ DISVEETSAK EGLLLWCQRK TAPYRNVNVQ
       190        200        210        220        230        240
NFHTSWKDGL ALCALIHRHR PDLIDYAKLR KDDPIGNLNT AFEVAEKYLD IPKMLDAEDI
       250        260        270        280        290        300
VNTPKPDEKA IMTYVSCFYH AFAGAEQAET AANRICKVLA VNQENEKLME EYEKLASELL
       310        320        330        340        350        360
EWIRRTVPWL ENRVGEPSMS AMQRKLEDFR DYRRLHKPPR VQEKCQLEIN FNTLQTKLRL
       370        380        390        400        410        420
SHRPAFMPSE GKLVSDIANA WRGLEQVEKG YEDWLLSEIR RLQRLQHLAE KFQQKASLHE
       430        440        450        460        470        480
AWTRGKEEML NQHDYESASL QEVRALLRRH EAFESDLAAH QDRVEHIAAL AQELNELDYH
       490        500        510        520        530        540
EAASVNSRCQ AICDQWDNLG TLTQKRRDAL ERMEKLLETI DQLQLEFARR AAPFNNWLDG
       550        560        570        580        590        600
AIEDLQDVWL VHSVEETQSL LTAHEQFKAT LPEADRERGA ILGIQGEIQK ICQTYGLRPK
       610        620        630        640        650        660
SGNPYITLSS QDINNKWDTV RKLVPSRDQT LQEELARQQV NERLRRQFAA QANAIGPWIQ
       670        680        690        700        710        720
GKVEEVGRLA AGLAGSLEEQ MAGLRQQEQN IINYKSNIDR LEGDHQLLQE SLVFDNKHTV
       730        740        750        760        770        780
YSMEHIRVGW EQLLTSIART INEVENQVLT RDAKGLSQEQ LNEFRASFNH FDRKRNGMME
       790        800        810        820        830        840
PDDFRACLIS MGYDLGEVEF ARIMTMVDPN AAGVVTFQAF IDFMTRETAE TDTAEQVVAS
       850        860        870        880        890        900
FKILAGDKNY ITPEELRREL PAEQAEYCIR RMAPYKGSGA PSGALDYVAF SSALYGESDL

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

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Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
O88990-1-Acetylation	MMMVMQ...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O88990-61-unknown	AGTQIE...	61		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33193
O88990-348-unknown	EINFNT...	348		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29595
O88990-352-unknown	NTLQTK...	352		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28688
O88990-352-unknown	NTLQTK...	352		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29596

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SHLRKA	60	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33193
...EKCQLE	347	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29595
...LEINFN	351	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28688
...LEINFN	351	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29596
...GESDL	900	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	60	LRKA.\|.AGTQ	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATE_MOUSE	347	CQLE.\|.EINF	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ACTN3_MOUSE @347
CATD_MOUSE	351	INFN.\|.NTLQ	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> ACTN3_MOUSE @351
CATE_MOUSE	351	INFN.\|.NTLQ	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ACTN3_MOUSE @351

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)