P63242: Eukaryotic translation initiation factor 5A-1

General Information

Protein names	- Eukaryotic translation initiation factor 5A-1 - eIF-5A-1 - eIF-5A1 - Eukaryotic initiation factor 5A isoform 1 - eIF-5A - eIF-4D
Gene names	Eif5a
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P63242

15 N-termini

11 C-termini

13 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MADDLDFETG DAGASATFPM QCSALRKNGF VVLKGRPCKI VEMSTSKTGK HGHAKVHLVG
        70         80         90        100        110        120
IDIFTGKKYE DICPSTHNMD VPNIKRNDFQ LIGIQDGYLS LLQDSGEVRE DLRLPEGDLG
       130        140        150
KEIEQKYDCG EEILITVLSA MTEEAAVAIK AMAK

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

15 N-termini - 11 C-termini - 13 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P63242-2-unknown	MADDLD...	1		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P63242-2-unknown	MADDLD...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P63242-2-Acetylation	ADDLDF...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P63242-2-Acetylation	ADDLDF...	2	acetylation-	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P63242-6-unknown	DFETGD...	6		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30249
P63242-6-unknown	DFETGD...	6		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29033
P63242-7-unknown	FETGDA...	7		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29034
P63242-8-unknown	ETGDAG...	8		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30250
P63242-8-unknown	ETGDAG...	8		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29035
P63242-9-unknown	TGDAGA...	9		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC32375
P63242-12-unknown	AGASAT...	12		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC32376
P63242-12-unmodified	AGASAT...	12			N-TAILS		Overall CM.	Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies...	20208520
P63242-24-unknown	ALRKNG...	24		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P63242-74-unmodified	PSTHNM...	74			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P63242-79-unknown	MDVPNI...	79		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSMUSP00000137459
P63242-92-unknown	IGIQDG...	92		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30251
P63242-92-unknown	IGIQDG...	92		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29036
P63242-98-unknown	YLSLLQ...	98		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29037
P63242-99-unknown	LSLLQD...	99		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29038
P63242-102-unknown	LQDSGE...	102		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29039
P63242-102-unknown	LQDSGE...	102		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33751

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...MADDLD	5	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30249
...MADDLD	5	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29033
...ADDLDF	6	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29034
...DDLDFE	7	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30250
...DDLDFE	7	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29035
...DLDFET	8	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32375
...FETGDA	11	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32376
...NDFQLI	91	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30251
...NDFQLI	91	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29036
...GIQDGY	97	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29037
...IQDGYL	98	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29038
...GYLSLL	101	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29039
...GYLSLL	101	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33751
...AAVAIK	149	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000123402
...KAMAK	154	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATE_MOUSE	5	DDLD.\|.DFET	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> IF5A1_MOUSE @5
CATD_MOUSE	5	DDLD.\|.DFET	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> IF5A1_MOUSE @5
CATD_MOUSE	6	DLDF.\|.FETG	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> IF5A1_MOUSE @6
CATE_MOUSE	7	LDFE.\|.ETGD	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> IF5A1_MOUSE @7
CATD_MOUSE	7	LDFE.\|.ETGD	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> IF5A1_MOUSE @7
GRAB_MOUSE	8	DFET.\|.TGDA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAB_MOUSE	11	TGDA.\|.AGAS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CATE_MOUSE	91	FQLI.\|.IGIQ	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> IF5A1_MOUSE @91
CATD_MOUSE	91	FQLI.\|.IGIQ	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> IF5A1_MOUSE @91
CATD_MOUSE	97	QDGY.\|.YLSL	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> IF5A1_MOUSE @97
CATD_MOUSE	98	DGYL.\|.LSLL	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> IF5A1_MOUSE @98
CATD_MOUSE	101	LSLL.\|.LQDS	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> IF5A1_MOUSE @101
MMP2_MOUSE	101	LSLL.\|.LQDS	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)