P60843: Eukaryotic initiation factor 4A-I

General Information

Protein names	- Eukaryotic initiation factor 4A-I - eIF-4A-I - eIF4A-I - 3.6.4.13 - ATP-dependent RNA helicase eIF4A-1
Gene names	Eif4a1
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P60843

6 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSASQDSRSR DNGPDGMEPE GVIESNWNEI VDSFDDMNLS ESLLRGIYAY GFEKPSAIQQ
        70         80         90        100        110        120
RAILPCIKGY DVIAQAQSGT GKTATFAISI LQQIELDLKA TQALVLAPTR ELAQQIQKVV
       130        140        150        160        170        180
MALGDYMGAS CHACIGGTNV RAEVQKLQME APHIIVGTPG RVFDMLNRRY LSPKYIKMFV
       190        200        210        220        230        240
LDEADEMLSR GFKDQIYDIF QKLNSNTQVV LLSATMPSDV LEVTKKFMRD PIRILVKKEE
       250        260        270        280        290        300
LTLEGIRQFY INVEREEWKL DTLCDLYETL TITQAVIFIN TRRKVDWLTE KMHARDFTVS
       310        320        330        340        350        360
AMHGDMDQKE RDVIMREFRS GSSRVLITTD LLARGIDVQQ VSLVINYDLP TNRENYIHRI
       370        380        390        400
GRGGRFGRKG VAINMVTEED KRTLRDIETF YNTSIEEMPL NVADLI

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
P60843-2-unknown	MSASQD...	1		inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P60843-2-unknown	MSASQD...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P60843-2-Acetylation	SASQDS...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P60843-2-Acetylation	SASQDS...	2	acetylation-	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P60843-8-unknown	RSRDNG...	8		inferred from electronic annotation	unknown	TISdb	inferred from TISdb
P60843-41-unknown	ESLLRG...	41		inferred from electronic annotation	unknown	TISdb	inferred from TISdb
P60843-49-unknown	AYGFEK...	49		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28964
P60843-147-unknown	LQMEAP...	147		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33671

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LRGIYA	48	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28964
...AEVQKL	146	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33671
...VADLI	406	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATD_MOUSE	48	GIYA.\|.AYGF	inferred from experiment	unknown	MEROPS	Zornig M	Melzer IM et al.:The Apaf-1-binding protein Aven... (A01.009)	22388353,
MMP2_MOUSE	146	VQKL.\|.LQME	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)