P27546: Microtubule-associated protein 4

General Information

Protein names	- Microtubule-associated protein 4 - MAP-4
Gene names	Map4
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P27546

7 N-termini

5 C-termini

6 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Microtubule-associated protein 4 - Isoform 3 of Microtubule-associated protein 4 - Isoform 4 of Microtubule-associated protein 4 - Isoform 4 of Microtubule-associated protein 4

Sequence View

        10         20         30         40         50         60
MADLSLVDAL TEPPPEIEGE IKRDFMAALE AEPYDDIVGE TVEKTEFIPL LDGDEKTGNS
        70         80         90        100        110        120
ESKKKPCLDT SQVEGIPSSK PTLLANGDHG MEGNNTAGSP TDFLEERVDY PDYQSSQNWP
       130        140        150        160        170        180
EDASFCFQPQ QVLDTDQAEP FNEHRDDGLA DLLFVSSGPT NASAFTERDN PSEDSYGMLP
       190        200        210        220        230        240
CDSFASTAVV SQEWSVGAPN SPCSESCVSP EVTIETLQPA TELSKAAEVE SVKEQLPAKA
       250        260        270        280        290        300
LETMAEQTTD VVHSPSTDTT PGPDTEAALA KDIEEITKPD VILANVTQPS TESDMFLAQD
       310        320        330        340        350        360
MELLTGTEAA HANNIILPTE PDESSTKDVA PPMEEEIVPG NDTTSPKETE TTLPIKMDLA
       370        380        390        400        410        420
PPEDVLLTKE TELAPAKGMV SLSEIEEALA KNDESSAEIP VAQETVVSET EVVLATEVVL
       430        440        450        460        470        480
PSDPITTLTK DVTLPLEAER PLVTDMTPSL ETEMTLGKET APPTETNLGM AKDMSPLPES
       490        500        510        520        530        540
EVTLGKDVVI LPETKVAEFN NVTPLSEEEV TSVKDMSPSA ETEAPLAKNA DLHSGTELIV
       550        560        570        580        590        600
DNSMAPASDL ALPLETKVAT VPIKDKGTVQ TEEKPREDSQ LASMQHKGQS TVPPCTASPE
       610        620        630        640        650        660
PVKAAEQMST LPIDAPSPLE NLEQKETPGS QPSEPCSGVS RQEEAKAAVG VTGNDITTPP
       670        680        690        700        710        720
NKEPPPSPEK KAKPLATTQP AKTSTSKAKT QPTSLPKQPA PTTSGGLNKK PMSLASGSVP
       730        740        750        760        770        780
AAPHKRPAAA TATARPSTLP ARDVKPKPIT EAKVAEKRTS PSKPSSAPAL KPGPKTTPTV
       790        800        810        820        830        840
SKATSPSTLV STGPSSRSPA TTLPKRPTSI KTEGKPADVK RMTAKSASAD LSRSKTTSAS
       850        860        870        880        890        900
SVKRNTTPTG AAPPAGMTST RVKPMSAPSR SSGALSVDKK PTSTKPSSSA PRVSRLATTV
       910        920        930        940        950        960
SAPDLKSVRS KVGSTENIKH QPGGGRAKVE KKTEAATTAG KPEPNAVTKA AGSIASAQKP
       970        980        990       1000       1010       1020
PAGKVQIVSK KVSYSHIQSK CGSKDNIKHV PGGGNVQIQN KKVDISKVSS KCGSKANIKH
      1030       1040       1050       1060       1070       1080
KPGGGDVKIE SQKLNFKEKA QAKVGSLDNV GHLPAGGAVK TEGGGSEALP CPGPPAGEEP
      1090       1100       1110       1120
VIPEAAPDAG APTSASGLSG HTTLSGGGDQ REPQTLDSQI QETSI         10         20         30         40         50         60
MADLSLVDAL TEPPPEIEGE IKRDFMAALE AEPYDDIVGE TVEKTEFIPL LDGDEKTGNS
        70         80         90        100        110        120
ESKKKPCLDT SQVEGIPSSK PTLLANGDHG MEGNNTAGSP TDFLEERVDY PDYQSSQNWP
       130        140        150        160        170        180
EDASFCFQPQ QVLDTDQAEP FNEHRDDGLA DLLFVSSGPT NASAFTERDN PSEDSYGMLP
       190        200        210        220        230        240
CDSFASTAVV SQEWSVGAPN SPCSESCVSP EVTIETLQPA TELSKAAEVE SVKEQLPAKA
       250        260        270        280        290        300
LETMAEQTTD VVHSPSTDTT PGPDTEAALA KDIEEITKPD VILANVTQPS TESDMFLAQD
       310        320        330        340        350        360
MELLTGTEAA HANNIILPTE PDESSTKDVA PPMEEEIVPG NDTTSPKETE TTLPIKMDLA
       370        380        390        400        410        420
PPEDVLLTKE TELAPAKGMV SLSEIEEALA KNDESSAEIP VAQETVVSET EVVLATEVVL
       430        440        450        460        470        480
PSDPITTLTK DVTLPLEAER PLVTDMTPSL ETEMTLGKET APPTETNLGM AKDMSPLPES
       490        500        510        520        530        540
EVTLGKDVVI LPETKVAEFN NVTPLSEEEV TSVKDMSPSA ETEAPLAKNA DLHSGTELIV
       550        560        570        580        590        600
DNSMAPASDL ALPLETKVAT VPIKDKGTVQ TEEKPREDSQ LASMQHKGQS TVPPCTASPE
       610        620        630        640        650        660
PVKAAEQMST LPIDAPSPLE NLEQKETPGS QPSEPCSGVS RQEEAKAAVG VTGNDITTPP
       670        680        690        700        710        720
NKEPPPSPEK KAKPLATTQP AKTSTSKAKT QPTSLPKQPA PTTSGGLNKK PMSLASGSVP
       730        740        750        760        770        780
AAPHKRPAAA TATARPSTLP ARDVKPKPIT EAKVAEKRTS PSKPSSAPAL KPGPKTTPTV
       790        800        810        820        830        840
SKATSPSTLV STGPSSRSPA TTLPKRPTSI KTEGKPADVK RMTAKSASAD LSRSKTTSAS
       850        860        870        880        890        900
SVKRNTTPTG AAPPAGMTST RVKPMSAPSR SSGALSVDKK PTSTKPSSSA PRVSRLATTV
       910        920        930        940        950        960
SAPDLKSVRS KVGSTENIKH QPGGGRAKVE KKTEAATTAG KPEPNAVTKA AGSIASAQKP
       970        980        990       1000       1010       1020
PAGKVQIVSK KVSYSHIQSK CGSKDNIKHV PGGGNVQIQN KKVDISKVSS KCGSKANIKH
      1030       1040       1050       1060       1070       1080
KPGGGDVKIE SQKLNFKEKA QAKVGSLDNV GHLPAGGAVK TEGGGSEALP CPGPPAGEEP
      1090       1100       1110       1120
VIPEAAPDAG APTSASGLSG HTTLSGGGDQ REPQTLDSQI QETSI         10         20         30         40         50         60
MADLSLVDAL TEPPPEIEGE IKRDFMAALE AEPYDDIVGE TVEKTEFIPL LDGDEKTGNS
        70         80         90        100        110        120
ESKKKPCLDT SQVEGIPSSK PTLLANGDHG MEGNNTAGSP TDFLEERVDY PDYQSSQNWP
       130        140        150        160        170        180
EDASFCFQPQ QVLDTDQAEP FNEHRDDGLA DLLFVSSGPT NASAFTERDN PSEDSYGMLP
       190        200        210        220        230        240
CDSFASTAVV SQEWSVGAPN SPCSESCVSP EVTIETLQPA TELSKAAEVE SVKEQLPAKA
       250        260        270        280        290        300
LETMAEQTTD VVHSPSTDTT PGPDTEAALA KDIEEITKPD VILANVTQPS TESDMFLAQD
       310        320        330        340        350        360
MELLTGTEAA HANNIILPTE PDESSTKDVA PPMEEEIVPG NDTTSPKETE TTLPIKMDLA
       370        380        390        400        410        420
PPEDVLLTKE TELAPAKGMV SLSEIEEALA KNDESSAEIP VAQETVVSET EVVLATEVVL
       430        440        450        460        470        480
PSDPITTLTK DVTLPLEAER PLVTDMTPSL ETEMTLGKET APPTETNLGM AKDMSPLPES
       490        500        510        520        530        540
EVTLGKDVVI LPETKVAEFN NVTPLSEEEV TSVKDMSPSA ETEAPLAKNA DLHSGTELIV
       550        560        570        580        590        600
DNSMAPASDL ALPLETKVAT VPIKDKGTVQ TEEKPREDSQ LASMQHKGQS TVPPCTASPE
       610        620        630        640        650        660
PVKAAEQMST LPIDAPSPLE NLEQKETPGS QPSEPCSGVS RQEEAKAAVG VTGNDITTPP
       670        680        690        700        710        720
NKEPPPSPEK KAKPLATTQP AKTSTSKAKT QPTSLPKQPA PTTSGGLNKK PMSLASGSVP
       730        740        750        760        770        780
AAPHKRPAAA TATARPSTLP ARDVKPKPIT EAKVAEKRTS PSKPSSAPAL KPGPKTTPTV
       790        800        810        820        830        840
SKATSPSTLV STGPSSRSPA TTLPKRPTSI KTEGKPADVK RMTAKSASAD LSRSKTTSAS
       850        860        870        880        890        900
SVKRNTTPTG AAPPAGMTST RVKPMSAPSR SSGALSVDKK PTSTKPSSSA PRVSRLATTV
       910        920        930        940        950        960
SAPDLKSVRS KVGSTENIKH QPGGGRAKVE KKTEAATTAG KPEPNAVTKA AGSIASAQKP
       970        980        990       1000       1010       1020
PAGKVQIVSK KVSYSHIQSK CGSKDNIKHV PGGGNVQIQN KKVDISKVSS KCGSKANIKH
      1030       1040       1050       1060       1070       1080
KPGGGDVKIE SQKLNFKEKA QAKVGSLDNV GHLPAGGAVK TEGGGSEALP CPGPPAGEEP
      1090       1100       1110       1120
VIPEAAPDAG APTSASGLSG HTTLSGGGDQ REPQTLDSQI QETSI         10         20         30         40         50         60
MADLSLVDAL TEPPPEIEGE IKRDFMAALE AEPYDDIVGE TVEKTEFIPL LDGDEKTGNS
        70         80         90        100        110        120
ESKKKPCLDT SQVEGIPSSK PTLLANGDHG MEGNNTAGSP TDFLEERVDY PDYQSSQNWP
       130        140        150        160        170        180
EDASFCFQPQ QVLDTDQAEP FNEHRDDGLA DLLFVSSGPT NASAFTERDN PSEDSYGMLP
       190        200        210        220        230        240
CDSFASTAVV SQEWSVGAPN SPCSESCVSP EVTIETLQPA TELSKAAEVE SVKEQLPAKA
       250        260        270        280        290        300
LETMAEQTTD VVHSPSTDTT PGPDTEAALA KDIEEITKPD VILANVTQPS TESDMFLAQD
       310        320        330        340        350        360
MELLTGTEAA HANNIILPTE PDESSTKDVA PPMEEEIVPG NDTTSPKETE TTLPIKMDLA
       370        380        390        400        410        420
PPEDVLLTKE TELAPAKGMV SLSEIEEALA KNDESSAEIP VAQETVVSET EVVLATEVVL
       430        440        450        460        470        480
PSDPITTLTK DVTLPLEAER PLVTDMTPSL ETEMTLGKET APPTETNLGM AKDMSPLPES
       490        500        510        520        530        540
EVTLGKDVVI LPETKVAEFN NVTPLSEEEV TSVKDMSPSA ETEAPLAKNA DLHSGTELIV
       550        560        570        580        590        600
DNSMAPASDL ALPLETKVAT VPIKDKGTVQ TEEKPREDSQ LASMQHKGQS TVPPCTASPE
       610        620        630        640        650        660
PVKAAEQMST LPIDAPSPLE NLEQKETPGS QPSEPCSGVS RQEEAKAAVG VTGNDITTPP
       670        680        690        700        710        720
NKEPPPSPEK KAKPLATTQP AKTSTSKAKT QPTSLPKQPA PTTSGGLNKK PMSLASGSVP
       730        740        750        760        770        780
AAPHKRPAAA TATARPSTLP ARDVKPKPIT EAKVAEKRTS PSKPSSAPAL KPGPKTTPTV
       790        800        810        820        830        840
SKATSPSTLV STGPSSRSPA TTLPKRPTSI KTEGKPADVK RMTAKSASAD LSRSKTTSAS
       850        860        870        880        890        900
SVKRNTTPTG AAPPAGMTST RVKPMSAPSR SSGALSVDKK PTSTKPSSSA PRVSRLATTV
       910        920        930        940        950        960
SAPDLKSVRS KVGSTENIKH QPGGGRAKVE KKTEAATTAG KPEPNAVTKA AGSIASAQKP
       970        980        990       1000       1010       1020
PAGKVQIVSK KVSYSHIQSK CGSKDNIKHV PGGGNVQIQN KKVDISKVSS KCGSKANIKH
      1030       1040       1050       1060       1070       1080
KPGGGDVKIE SQKLNFKEKA QAKVGSLDNV GHLPAGGAVK TEGGGSEALP CPGPPAGEEP
      1090       1100       1110       1120
VIPEAAPDAG APTSASGLSG HTTLSGGGDQ REPQTLDSQI QETSI

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 5 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
P27546-2-unknown	MADLSL...	1		inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P27546-2-unknown	MADLSL...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P27546-1-unknown	MADLSL...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80368
P27546-1-unknown	MADLSL...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80369
P27546-2-Acetylation	ADLSLV...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P27546-2-Acetylation	ADLSLV...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt110052
P27546-2-Acetylation	ADLSLV...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt110053
P27546-2-Acetylation	ADLSLV...	2	acetylation-	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P27546-7-unknown	VDALTE...	7		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29889
P27546-7-unknown	VDALTE...	7		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt194770
P27546-7-unknown	VDALTE...	7		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt194771
P27546-154-unknown	FVSSGP...	154		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28849
P27546-154-unknown	FVSSGP...	154		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29890
P27546-154-unknown	FVSSGP...	154		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144914
P27546-154-unknown	FVSSGP...	154		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144915
P27546-623-unknown	EQKETP...	623		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28852
P27546-623-unknown	EQKETP...	623		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29893
P27546-623-unknown	EQKETP...	623		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt154946
P27546-623-unknown	EQKETP...	623		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt154947
P27546-879-unknown	KKPTST...	879		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32333
P27546-879-unknown	KKPTST...	879		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt156114
P27546-879-unknown	KKPTST...	879		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt156776
P27546-879-unknown	KKPTST...	879		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt156777

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ADLSLV	6	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29889
...LADLLF	153	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28849
...LADLLF	153	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29890
...LADLLF	153	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128190
...LADLLF	153	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128191
...PLENLE	622	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28852
...PLENLE	622	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29893
...PLENLE	622	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138373
...PLENLE	622	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138374
...ALSVDK	878	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32333
...ALSVDK	878	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139577
...ALSVDK	878	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140268
...ALSVDK	878	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140269
...QETSI	1125	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATE_MOUSE	6	LSLV.\|.VDAL	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> MAP4_MOUSE @6
CATD_MOUSE	153	DLLF.\|.FVSS	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> MAP4_MOUSE @153
CATE_MOUSE	153	DLLF.\|.FVSS	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> MAP4_MOUSE @153
CATD_MOUSE	622	ENLE.\|.EQKE	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> MAP4_MOUSE @622
CATE_MOUSE	622	ENLE.\|.EQKE	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> MAP4_MOUSE @622
GRAB_MOUSE	878	SVDK.\|.KKPT	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)