P39749: Flap endonuclease 1 {ECO:0000255|HAMAP-Rule:MF_03140}

General Information

Protein names	- Flap endonuclease 1 {ECO:0000255\|HAMAP-Rule:MF_03140} - FEN-1 {ECO:0000255\|HAMAP-Rule:MF_03140} - 3.1.-.- {ECO:0000255\|HAMAP-Rule:MF_03140} - Flap structure-specific endonuclease 1 {ECO:0000255\|HAMAP-Rule:MF_03140}
Gene names	Fen1
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P39749

4 N-termini

4 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGIHGLAKLI ADVAPSAIRE NDIKSYFGRK VAIDASMSIY QFLIAVRQGG DVLQNEEGET
        70         80         90        100        110        120
TSLMGMFYRT IRMENGIKPV YVFDGKPPQL KSGELAKRSE RRAEAEKQLQ QAQEAGMEEE
       130        140        150        160        170        180
VEKFTKRLVK VTKQHNDECK HLLSLMGIPY LDAPSEAEAS CAALAKAGKV YAAATEDMDC
       190        200        210        220        230        240
LTFGSPVLMR HLTASEAKKL PIQEFHLSRV LQELGLNQEQ FVDLCILLGS DYCESIRGIG
       250        260        270        280        290        300
AKRAVDLIQK HKSIEEIVRR LDPSKYPVPE NWLHKEAQQL FLEPEVVDPE SVELKWSEPN
       310        320        330        340        350        360
EEELVKFMCG EKQFSEERIR SGVKRLSKSR QGSTQGRLDD FFKVTGSLSS AKRKEPEPKG
       370
PAKKKAKTGG AGKFRRGK

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P39749-1-unknown	MGIHGL...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P39749-308-unknown	MCGEKQ...	308	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28874
P39749-309-unknown	CGEKQF...	309	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32608
P39749-342-unknown	FKVTGS...	342	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28875
P39749-342-unknown	FKVTGS...	342	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29935

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ELVKFM	307	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28874
...LVKFMC	308	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32608
...RLDDFF	341	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC28875
...RLDDFF	341	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29935
...FRRGK	378	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATD_MOUSE	307	VKFM.\|.MCGE	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> FEN1_MOUSE @307
GRAC_MOUSE	308	KFMC.\|.CGEK	inferred from experiment	unknown	MEROPS	Bird PI	Kaiserman D et al.:Structure of granzyme C reveals... (S01.137)	19299505,
CATD_MOUSE	341	DDFF.\|.FKVT	inferred from experiment	unknown	MEROPS		Merops CATD_MOUSE -> FEN1_MOUSE @341
CATE_MOUSE	341	DDFF.\|.FKVT	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> FEN1_MOUSE @341

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)