Q7TPR4: Alpha-actinin-1

General Information

Protein names	- Alpha-actinin-1 - Alpha-actinin cytoskeletal isoform - F-actin cross-linking protein - Non-muscle alpha-actinin-1
Gene names	Actn1
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q7TPR4

12 N-termini

7 C-termini

7 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDHYDSQQTN DYMQPEEDWD RDLLLDPAWE KQQRKTFTAW CNSHLRKAGT QIENIEEDFR
        70         80         90        100        110        120
DGLKLMLLLE VISGERLAKP ERGKMRVHKI SNVNKALDFI ASKGVKLVSI GAEEIVDGNV
       130        140        150        160        170        180
KMTLGMIWTI ILRFAIQDIS VEETSAKEGL LLWCQRKTAP YKNVNIQNFH ISWKDGLGFC
       190        200        210        220        230        240
ALIHRHRPEL IDYGKLRKDD PLTNLNTAFD VAERFLDIPK MLDAEDIVGT ARPDEKAIMT
       250        260        270        280        290        300
YVSSFYHAFS GAQKAETAAN RICKVLAVNQ ENEQLMEDYE KLASDLLEWI RRTIPWLENR
       310        320        330        340        350        360
VPENTMHAMQ QKLEDFRDYR RLHKPPKVQE KCQLEINFNT LQTKLRLSNR PAFMPSEGRM
       370        380        390        400        410        420
VSDINNAWGC LEQAEKGYEE WLLNEIRRLE RLDHLAEKFR QKASIHEAWT DGKEAMLRQK
       430        440        450        460        470        480
DYETATLSEI KALLKKHEAF ESDLAAHQDR VEQIAAIAQE LNELDYYDSP SVNARCQKIC
       490        500        510        520        530        540
DQWDNLGALT QKRREALERT EKLLETIDQL YLEYAKRAAP FNNWMEGAME DLQDTFIVHT
       550        560        570        580        590        600
IEEIQGLTTA HEQFKATLPD ADKERLAILG IHNEVSKIVQ TYHVNMAGTN PYTTITPQEI
       610        620        630        640        650        660
NGKWDHVRQL VPRRDQALTE EHARQQHNER LRKQFGAQAN VIGPWIQTKM EEIGRISIEM
       670        680        690        700        710        720
HGTLEDQLSH LRQYEKSIVN YKPKIDQLEC DHQLIQEALI FDNKHTNYNM EHIRVGWEQL
       730        740        750        760        770        780
LTTIARTINE VENQILTRDA KGISQEQMNE FRASFNHFDR DHSGTLGPEE FKACLISLGY
       790        800        810        820        830        840
DIGNDPQGEA EFARIMSIVD PNRLGVVTFQ AFIDFMSRET ADTDTADQVM ASFKILAGDK
       850        860        870        880        890
NYITEDELRR ELPPDQAEYC IARMAPYAGP DSVPGALDYM SFSTALYGES DL

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

12 N-termini - 7 C-termini - 7 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q7TPR4-1-Acetylation	MDHYDS...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q7TPR4-6-Acetylation	SQQTND...	6	acetylation-		N-TAILS		Overall CM.	Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies...	20208520
Q7TPR4-6-unknown	SQQTND...	6			N-TAILS		Overall CM.	auf dem Keller U.: A statistics-based platform for quantitative N-terminome...	20305283
Q7TPR4-48-unknown	AGTQIE...	48		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34046
Q7TPR4-83-unknown	GKMRVH...	83		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q7TPR4-252-unknown	AQKAET...	252		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30679
Q7TPR4-288-unknown	EWIRRT...	288		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q7TPR4-335-unknown	EINFNT...	335		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30680
Q7TPR4-339-unknown	NTLQTK...	339		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29220
Q7TPR4-339-unknown	NTLQTK...	339		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30681
Q7TPR4-476-5oxothiomorpholine-3-carboxylic-acid	CQKICD...	476			N-TAILS		Overall CM.	Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies...	20208520
Q7TPR4-555-unknown	KATLPD...	555		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30682
Q7TPR4-833-unknown	FKILAG...	833		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34047

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SHLRKA	47	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34046
...HAFSGA	251	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30679
...EKCQLE	334	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30680
...LEINFN	338	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29220
...LEINFN	338	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30681
...AHEQFK	554	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30682
...QVMASF	832	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34047
...GESDL	892	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	47	LRKA.\|.AGTQ	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATE_MOUSE	251	FSGA.\|.AQKA	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ACTN1_MOUSE @251
CATE_MOUSE	334	CQLE.\|.EINF	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ACTN1_MOUSE @334
CATD_MOUSE	338	INFN.\|.NTLQ	inferred from experiment	unknown	MEROPS	Zornig M	Melzer IM et al.:The Apaf-1-binding protein Aven... (A01.009)	22388353,
CATE_MOUSE	338	INFN.\|.NTLQ	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ACTN1_MOUSE @338
CATE_MOUSE	554	EQFK.\|.KATL	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ACTN1_MOUSE @554
MMP2_MOUSE	832	MASF.\|.FKIL	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)