P02469: Laminin subunit beta-1

General Information

Protein names	- Laminin subunit beta-1 - Laminin B1 chain - Laminin-1 subunit beta - Laminin-10 subunit beta - Laminin-12 subunit beta - Laminin-2 subunit beta - Laminin-6 subunit beta - Laminin-8 subunit beta
Gene names	Lamb1
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P02469

9 N-termini

8 C-termini

7 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGLLQVFAFG VLALWGTRVC AQEPEFSYGC AEGSCYPATG DLLIGRAQKL SVTSTCGLHK
        70         80         90        100        110        120
PEPYCIVSHL QEDKKCFICD SRDPYHETLN PDSHLIENVV TTFAPNRLKI WWQSENGVEN
       130        140        150        160        170        180
VTIQLDLEAE FHFTHLIMTF KTFRPAAMLI ERSSDFGKAW GVYRYFAYDC ESSFPGISTG
       190        200        210        220        230        240
PMKKVDDIIC DSRYSDIEPS TEGEVIFRAL DPAFKIEDPY SPRIQNLLKI TNLRIKFVKL
       250        260        270        280        290        300
HTLGDNLLDS RMEIREKYYY AVYDMVVRGN CFCYGHASEC APVDGVNEEV EGMVHGHCMC
       310        320        330        340        350        360
RHNTKGLNCE LCMDFYHDLP WRPAEGRNSN ACKKCNCNEH SSSCHFDMAV FLATGNVSGG
       370        380        390        400        410        420
VCDNCQHNTM GRNCEQCKPF YFQHPERDIR DPNLCEPCTC DPAGSENGGI CDGYTDFSVG
       430        440        450        460        470        480
LIAGQCRCKL HVEGERCDVC KEGFYDLSAE DPYGCKSCAC NPLGTIPGGN PCDSETGYCY
       490        500        510        520        530        540
CKRLVTGQRC DQCLPQHWGL SNDLDGCRPC DCDLGGALNN SCSEDSGQCS CLPHMIGRQC
       550        560        570        580        590        600
NEVESGYYFT TLDHYIYEAE EANLGPGVIV VERQYIQDRI PSWTGPGFVR VPEGAYLEFF
       610        620        630        640        650        660
IDNIPYSMEY EILIRYEPQL PDHWEKAVIT VQRPGKIPAS SRCGNTVPDD DNQVVSLSPG
       670        680        690        700        710        720
SRYVVLPRPV CFEKGMNYTV RLELPQYTAS GSDVESPYTF IDSLVLMPYC KSLDIFTVGG
       730        740        750        760        770        780
SGDGEVTNSA WETFQRYRCL ENSRSVVKTP MTDVCRNIIF SISALIHQTG LACECDPQGS
       790        800        810        820        830        840
LSSVCDPNGG QCQCRPNVVG RTCNRCAPGT FGFGPNGCKP CDCHLQGSAS AFCDAITGQC
       850        860        870        880        890        900
HCFQGIYARQ CDRCLPGYWG FPSCQPCQCN GHALDCDTVT GECLSCQDYT TGHNCERCLA
       910        920        930        940        950        960
GYYGDPIIGS GDHCRPCPCP DGPDSGRQFA RSCYQDPVTL QLACVCDPGY IGSRCDDCAS
       970        980        990       1000       1010       1020
GFFGNPSDFG GSCQPCQCHH NIDTTDPEAC DKETGRCLKC LYHTEGDHCQ LCQYGYYGDA
      1030       1040       1050       1060       1070       1080
LRQDCRKCVC NYLGTVKEHC NGSDCHCDKA TGQCSCLPNV IGQNCDRCAP NTWQLASGTG
      1090       1100       1110       1120       1130       1140
CGPCNCNAAH SFGPSCNEFT GQCQCMPGFG GRTCSECQEL FWGDPDVECR ACDCDPRGIE
      1150       1160       1170       1180       1190       1200
TPQCDQSTGQ CVCVEGVEGP RCDKCTRGYS GVFPDCTPCH QCFALWDAII GELTNRTHKF
      1210       1220       1230       1240       1250       1260
LEKAKALKIS GVIGPYRETV DSVEKKVNEI KDILAQSPAA EPLKNIGILF EEAEKLTKDV
      1270       1280       1290       1300       1310       1320
TEKMAQVEVK LTDTASQSNS TAGELGALQA EAESLDKTVK ELAEQLEFIK NSDIQGALDS
      1330       1340       1350       1360       1370       1380
ITKYFQMSLE AEKRVNASTT DPNSTVEQSA LTRDRVEDLM LERESPFKEQ QEEQARLLDE
      1390       1400       1410       1420       1430       1440
LAGKLQSLDL SAVAQMTCGT PPGADCSESE CGGPNCRTDE GEKKCGGPGC GGLVTVAHSA
      1450       1460       1470       1480       1490       1500
WQKAMDFDRD VLSALAEVEQ LSKMVSEAKV RADEAKQNAQ DVLLKTNATK EKVDKSNEDL
      1510       1520       1530       1540       1550       1560
RNLIKQIRNF LTEDSADLDS IEAVANEVLK MEMPSTPQQL QNLTEDIRER VETLSQVEVI
      1570       1580       1590       1600       1610       1620
LQQSAADIAR AELLLEEAKR ASKSATDVKV TADMVKEALE EAEKAQVAAE KAIKQADEDI
      1630       1640       1650       1660       1670       1680
QGTQNLLTSI ESETAASEET LTNASQRISK LERNVEELKR KAAQNSGEAE YIEKVVYSVK
      1690       1700       1710       1720       1730       1740
QNADDVKKTL DGELDEKYKK VESLIAQKTE ESADARRKAE LLQNEAKTLL AQANSKLQLL
      1750       1760       1770       1780
EDLERKYEDN QKYLEDKAQE LVRLEGEVRS LLKDISEKVA VYSTCL

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

9 N-termini - 8 C-termini - 7 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P02469-22-unknown	QEPEFS...	22		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P02469-28-unknown	YGCAEG...	28		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC32176
P02469-138-unknown	MTFKTF...	138		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC32177
P02469-983-unknown	DTTDPE...	983		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC32178
P02469-1357-unknown	EDLMLE...	1357		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC32179
P02469-1398-unknown	CGTPPG...	1398		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC32180
P02469-1442-Pyrrolidone carboxylic acid	QKAMDF...	1442	pyrrolidone carboxylic acid-		N-TAILS		Overall CM.	Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies...	20208520
P02469-1558-unknown	EVILQQ...	1558		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34512
P02469-1704-unknown	LIAQKT...	1704		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33203

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EPEFSY	27	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32176
...FTHLIM	137	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32177
...CHHNID	982	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32178
...TRDRVE	1356	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32179
...VAQMTC	1397	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32180
...TLSQVE	1557	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34512
...KKVESL	1703	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33203
...YSTCL	1786	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
ELNE_MOUSE	27	EFSY.\|.YGCA	inferred from experiment	unknown	MEROPS		Merops ELNE_MOUSE -> LAMB1_MOUSE @27
ELNE_MOUSE	137	HLIM.\|.MTFK	inferred from experiment	unknown	MEROPS		Merops ELNE_MOUSE -> LAMB1_MOUSE @137
ELNE_MOUSE	982	HNID.\|.DTTD	inferred from experiment	unknown	MEROPS		Merops ELNE_MOUSE -> LAMB1_MOUSE @982
ELNE_MOUSE	1356	DRVE.\|.EDLM	inferred from experiment	unknown	MEROPS		Merops ELNE_MOUSE -> LAMB1_MOUSE @1356
ELNE_MOUSE	1397	QMTC.\|.CGTP	inferred from experiment	unknown	MEROPS		Merops ELNE_MOUSE -> LAMB1_MOUSE @1397
MMP9_MOUSE	1557	SQVE.\|.EVIL	inferred from experiment	unknown	MEROPS		Merops MMP9_MOUSE -> LAMB1_MOUSE @1557
MMP2_MOUSE	1703	VESL.\|.LIAQ	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)