P28798: Progranulin {ECO:0000303|PubMed:12524533}

General Information

Protein names	- Progranulin {ECO:0000303\|PubMed:12524533} - PGRN {ECO:0000250\|UniProtKB:P28799} - Acrogranin {ECO:0000303\|PubMed:8482392} - Epithelin/granulin precursor {ECO:0000303\|PubMed:8482392} - Glycoprotein of 88 Kda {ECO:0000305\|PubMed:8496151} - GP88 - Glycoprotein 88 - PC cell-derived growth factor {ECO:0000303\|PubMed:8496151} - PCDGF {ECO:0000303\|PubMed:8496151} - Proepithelin {ECO:0000303\|PubMed:12526812} - PEPI {ECO:0000250\|UniProtKB:P28799} - Paragranulin - Granulin-1 - Granulin-2 - Granulin-3 - Granulin-4 - Granulin-5 - Granulin-6 - Granulin-7
Gene names	Grn
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P28798

5 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MWVLMSWLAF AAGLVAGTQC PDGQFCPVAC CLDQGGANYS CCNPLLDTWP RITSHHLDGS
        70         80         90        100        110        120
CQTHGHCPAG YSCLLTVSGT SSCCPFSKGV SCGDGYHCCP QGFHCSADGK SCFQMSDNPL
       130        140        150        160        170        180
GAVQCPGSQF ECPDSATCCI MVDGSWGCCP MPQASCCEDR VHCCPHGASC DLVHTRCVSP
       190        200        210        220        230        240
TGTHTLLKKF PAQKTNRAVS LPFSVVCPDA KTQCPDDSTC CELPTGKYGC CPMPNAICCS
       250        260        270        280        290        300
DHLHCCPQDT VCDLIQSKCL SKNYTTDLLT KLPGYPVKEV KCDMEVSCPE GYTCCRLNTG
       310        320        330        340        350        360
AWGCCPFAKA VCCEDHIHCC PAGFQCHTEK GTCEMGILQV PWMKKVIAPL RLPDPQILKS
       370        380        390        400        410        420
DTPCDDFTRC PTNNTCCKLN SGDWGCCPIP EAVCCSDNQH CCPQGFTCLA QGYCQKGDTM
       430        440        450        460        470        480
VAGLEKIPAR QTTPLQIGDI GCDQHTSCPV GQTCCPSLKG SWACCQLPHA VCCEDRQHCC
       490        500        510        520        530        540
PAGYTCNVKA RTCEKDVDFI QPPVLLTLGP KVGNVECGEG HFCHDNQTCC KDSAGVWACC
       550        560        570        580
PYLKGVCCRD GRHCCPGGFH CSARGTKCLR KKIPRWDMFL RDPVPRPLL

Isoforms

Sequence View

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(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P28798-2-unknown	WVLMSW...	2	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P28798-18-unknown	TQCPDG...	18	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P28798-358-unknown	LKSDTP...	358	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33513
P28798-360-unmodified	SDTPCD...	360		N-TAILS		Overall CM.	Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies...	20208520
P28798-360-unmodified	SDTPCD...	360		N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P28798-360-unknown	SDTPCD...	360		N-TAILS		Overall CM.	auf dem Keller U.: A statistics-based platform for quantitative N-terminome...	20305283

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...PDPQIL	357	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33513
	...PRPLL	589	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	357	PQIL.\|.LKSD	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)