P27773: Protein disulfide-isomerase A3

General Information

Protein names	- Protein disulfide-isomerase A3 - 5.3.4.1 - 58 kDa glucose-regulated protein - 58 kDa microsomal protein - p58 - Disulfide isomerase ER-60 - Endoplasmic reticulum resident protein 57 - ER protein 57 - ERp57 - Endoplasmic reticulum resident protein 60 - ER protein 60 - ERp60
Gene names	Pdia3
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P27773

14 N-termini

9 C-termini

8 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MRFSCLALLP GVALLLASAR LAAASDVLEL TDENFESRVS DTGSAGLMLV EFFAPWCGHC
        70         80         90        100        110        120
KRLAPEYEAA ATRLKGIVPL AKVDCTANTN TCNKYGVSGY PTLKIFRDGE EAGAYDGPRT
       130        140        150        160        170        180
ADGIVSHLKK QAGPASVPLR TEEEFKKFIS DKDASVVGFF RDLFSDGHSE FLKAASNLRD
       190        200        210        220        230        240
NYRFAHTNIE SLVKEYDDNG EGITIFRPLH LANKFEDKTV AYTEKKMTSG KIKKFIQDSI
       250        260        270        280        290        300
FGLCPHMTED NKDLIQGKDL LTAYYDVDYE KNAKGSNYWR NRVMMVAKKF LDAGHKLNFA
       310        320        330        340        350        360
VASRKTFSHE LSDFGLESTT GEVPVVAIRT AKGEKFVMQE EFSRDGKALE QFLQEYFDGN
       370        380        390        400        410        420
LKRYLKSEPI PESNEGPVKV VVAENFDDIV NEEDKDVLIE FYAPWCGHCK NLEPKYKELG
       430        440        450        460        470        480
EKLSKDPNIV IAKMDATAND VPSPYEVKGF PTIYFSPANK KLTPKKYEGG RELNDFISYL
       490        500
QREATNPPII QEEKPKKKKK AQEDL

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

14 N-termini - 9 C-termini - 8 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P27773-25-unknown	SDVLEL...	25	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P27773-25-unknown	SDVLEL...	25		N-TAILS		Overall CM.	auf dem Keller U.: A statistics-based platform for quantitative N-terminome...	20305283
P27773-25-unmodified	SDVLEL...	25		N-TAILS		Overall CM.	Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies...	20208520
P27773-25-unmodified	SDVLEL...	25		unknown			Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
P27773-25-unmodified	SDVLEL...	25		N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P27773-30-unknown	LTDENF...	30	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33498
P27773-31-unknown	TDENFE...	31	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29903
P27773-65-unknown	PEYEAA...	65	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P27773-108-unknown	DGEEAG...	108	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P27773-150-unknown	SDKDAS...	150	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P27773-165-unknown	SDGHSE...	165	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P27773-171-unknown	FLKAAS...	171	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29904
P27773-172-unknown	LKAASN...	172	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29905
P27773-317-unknown	ESTTGE...	317	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29906
P27773-328-unknown	IRTAKG...	328	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33499
P27773-353-unknown	LQEYFD...	353	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC29907
P27773-447-unknown	VKGFPT...	447	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33500

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SDVLEL	29	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33498
...DVLELT	30	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29903
...DGHSEF	170	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29904
...GHSEFL	171	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29905
...SDFGLE	316	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29906
...VPVVAI	327	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33499
...ALEQFL	352	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29907
...PSPYEV	446	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33500
...AQEDL	505	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	29	VLEL.\|.LTDE	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATE_MOUSE	30	LELT.\|.TDEN	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> PDIA3_MOUSE @30
CATE_MOUSE	170	HSEF.\|.FLKA	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> PDIA3_MOUSE @170
CATE_MOUSE	171	SEFL.\|.LKAA	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> PDIA3_MOUSE @171
CATE_MOUSE	316	FGLE.\|.ESTT	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> PDIA3_MOUSE @316
MMP2_MOUSE	327	VVAI.\|.IRTA	inferred from experiment	unknown	MEROPS		Merops MMP2_MOUSE -> PDIA3_MOUSE @327
CATE_MOUSE	352	EQFL.\|.LQEY	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> PDIA3_MOUSE @352
MMP2_MOUSE	446	PYEV.\|.VKGF	inferred from experiment	unknown	MEROPS		Merops MMP2_MOUSE -> PDIA3_MOUSE @446

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)