Q64727: Vinculin

General Information

Protein names	- Vinculin - Metavinculin
Gene names	Vcl
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q64727

6 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPVFHTRTIE SILEPVAQQI SHLVIMHEEG EVDGKAIPDL TAPVAAVQAA VSNLVRVGKE
        70         80         90        100        110        120
TVQTTEDQIL KRDMPPAFIK VENACTKLVQ AAQMLQSDPY SVPARDYLID GSRGILSGTS
       130        140        150        160        170        180
DLLLTFDEAE VRKIIRVCKG ILEYLTVAEV VETMEDLVTY TKNLGPGMTK MAKMIDERQQ
       190        200        210        220        230        240
ELTHQEHRVM LVNSMNTVKE LLPVLISAMK IFVTTKNSKN QGIEEALKNR NFTVEKMSAE
       250        260        270        280        290        300
INEIIRVLQL TSWDEDAWAS KDTEAMKRAL ASIDSKLNQA KGWLRDPNAS PGDAGEQAIR
       310        320        330        340        350        360
QILDEAGKVG ELCAGKERRE ILGTCKMLGQ MTDQVADLRA RGQGASPVAM QKAQQVSQGL
       370        380        390        400        410        420
DVLTAKVENA ARKLEAMTNS KQSIAKKIDA AQNWLADPNG GPEGEEQIRG ALAEARKIAE
       430        440        450        460        470        480
LCDDPKERDD ILRSLGEIAA LTSKLGDLRR QGKGDSPEAR ALAKQVATAL QNLQTKTNRA
       490        500        510        520        530        540
VANSRPAKAA VHLEGKIEQA QRWIDNPTVD DRGVGQAAIR GLVAEGHRLA NVMMGPYRQD
       550        560        570        580        590        600
LLAKCDRVDQ LTAQLADLAA RGEGESPQAR ALASQLQDSL KDLKAQMQEA MTQEVSDVFS
       610        620        630        640        650        660
DTTTPIKLLA VAATAPPDAP NREEVFDERA ANFENHSGRL GATAEKAAAV GTANKSTVEG
       670        680        690        700        710        720
IQASVKTARE LTPQVISAAR ILLRNPGNQA AYEHFETMKN QWIDNVEKMT GLVDEAIDTK
       730        740        750        760        770        780
SLLDASEEAI KKDLDKCKVA MANIQPQMLV AGATSIARRA NRILLVAKRE VENSEDPKFR
       790        800        810        820        830        840
EAVKAASDEL SKTISPMVMD AKAVAGNISD PGLQKSFLDS GYRILGAVAK VREAFQPQEP
       850        860        870        880        890        900
DFPPPPPDLE QLRLTDELAP PKPPLPEGEV PPPRPPPPEE KDEEFPEQKA GEVINQPMMM
       910        920        930        940        950        960
AARQLHDEAR KWSSKGNDII AAAKRMALLM AEMSRLVRGG SGTKRALIQC AKDIAKASDE
       970        980        990       1000       1010       1020
VTRLAKEVAK QCTDKRIRTN LLQVCERIPT ISTQLKILST VKATMLGRTN ISDEESEQAT
      1030       1040       1050       1060
EMLVHNAQNL MQSVKETVRE AEAASIKIRT DAGFTLRWVR KTPWYQ

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

6 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q64727-2-unknown	PVFHTR...	2		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q64727-2-unknown	PVFHTR...	2		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q64727-200-unknown	ELLPVL...	200		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q64727-250-unknown	LTSWDE...	250		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34006
Q64727-301-Pyrrolidone carboxylic acid	QILDEA...	301	pyrrolidone carboxylic acid-		N-TAILS		Overall CM.	Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies...	20208520
Q64727-301-Pyrrolidone carboxylic acid	QILDEA...	301	pyrrolidone carboxylic acid-		unknown			Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
Q64727-323-unknown	GTCKML...	323		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q64727-493-unknown	LEGKIE...	493		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34007

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IRVLQL	249	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34006
...KAAVHL	492	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34007
...TPWYQ	1066	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	249	VLQL.\|.LTSW	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	492	AVHL.\|.LEGK	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)