P28352: DNA-(apurinic or apyrimidinic site) lyase

General Information

Protein names	- DNA-(apurinic or apyrimidinic site) lyase - 3.1.-.- - 4.2.99.18 - APEX nuclease - APEN - Apurinic-apyrimidinic endonuclease 1 - AP endonuclease 1 - REF-1 - Redox factor-1 - DNA-(apurinic or apyrimidinic site) lyase, mitochondrial
Gene names	Apex1
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P28352

7 N-termini

5 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPKRGKKAAA DDGEEPKSEP ETKKSKGAAK KTEKEAAGEG PVLYEDPPDQ KTSPSGKSAT
        70         80         90        100        110        120
LKICSWNVDG LRAWIKKKGL DWVKEEAPDI LCLQETKCSE NKLPAELQEL PGLTHQYWSA
       130        140        150        160        170        180
PSDKEGYSGV GLLSRQCPLK VSYGIGEEEH DQEGRVIVAE FESFVLVTAY VPNAGRGLVR
       190        200        210        220        230        240
LEYRQRWDEA FRKFLKDLAS RKPLVLCGDL NVAHEEIDLR NPKGNKKNAG FTPQERQGFG
       250        260        270        280        290        300
ELLQAVPLAD SFRHLYPNTA YAYTFWTYMM NARSKNVGWR LDYFLLSHSL LPALCDSKIR
       310
SKALGSDHCP ITLYLAL

Isoforms

Sequence View

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Directness:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

7 N-termini - 5 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P28352-2-unknown	PKRGKK...	2		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P28352-6-unknown	KKAAAD...	6		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSMUSP00000116319
P28352-31-Acetylation	KTEKEA...	31	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P28352-31-Acetylation	KTEKEA...	31	acetylation-	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P28352-118-unknown	WSAPSD...	118		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33501
P28352-142-unmodified	SYGIGE...	142			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P28352-210-unknown	LNVAHE...	210		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33502
P28352-210-unknown	LNVAHE...	210		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P28352-210-unknown	LNVAHE...	210		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P28352-227-unmodified	KNAGFT...	227			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EDPPDQ	49	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000122343
...LTHQYW	117	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33501
...NAGRGL	177	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000123148
...VLCGDL	209	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33502
...LYLAL	317	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	117	HQYW.\|.WSAP	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	209	CGDL.\|.LNVA	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)