P06797: Cathepsin L1
| Protein names | - Cathepsin L1 - 3.4.22.15 {ECO:0000269|PubMed:8554545} - Cathepsin L - Major excreted protein - MEP - p39 cysteine proteinase - Cathepsin L1 heavy chain - Cathepsin L1 light chain |
|---|---|
| Gene names | Ctsl |
| Organism | Mus musculus |
| Protease Family | C01.032 |
| Protease ID | C01.032 |
| Chromosome location | |
| UniProt ID | P06797 |
8
N-termini
7
C-termini
5
Cleavages
14
Substrates
Sequence
10 20 30 40 50 60
MNLLLLLAVL CLGTALATPK FDQTFSAEWH QWKSTHRRLY GTNEEEWRRA IWEKNMRMIQ
70 80 90 100 110 120
LHNGEYSNGQ HGFSMEMNAF GDMTNEEFRQ VVNGYRHQKH KKGRLFQEPL MLKIPKSVDW
130 140 150 160 170 180
REKGCVTPVK NQGQCGSCWA FSASGCLEGQ MFLKTGKLIS LSEQNLVDCS HAQGNQGCNG
190 200 210 220 230 240
GLMDFAFQYI KENGGLDSEE SYPYEAKDGS CKYRAEFAVA NDTGFVDIPQ QEKALMKAVA
250 260 270 280 290 300
TVGPISVAMD ASHPSLQFYS SGIYYEPNCS SKNLDHGVLL VGYGYEGTDS NKNKYWLVKN
310 320 330
SWGSEWGMEG YIKIAKDRDN HCGLATAASY PVVN
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
8 N-termini - 7 C-termini - 5 Cleavages - 14 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| P06797-39-unknown | LYGTNE... | 39 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC33237 | |||
| P06797-77-unknown | MNAFGD... | 77 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC33238 | |||
| P06797-114-unknown | IPKSVD... | 114 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| P06797-241-unknown | TVGPIS... | 241 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC33239 | |||
| P06797-291-unknown | NKNKYW... | 291 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| P06797-311-unknown | YIKIAK... | 311 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC29642 | |||
| P06797-317-unmodified | DRDNHC... | 317 | N-TAILS | Overall CM. | Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies... | 20208520 | |||
| P06797-319-unknown | DNHCGL... | 319 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC33240 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...STHRRL | 38 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC33237 | |||
| ...GFSMEM | 76 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC33238 | |||
| ...MKAVAT | 240 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC33239 | |||
| ...GYEGTD | 288 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| ...WGMEGY | 310 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC29642 | |||
| ...IAKDRD | 318 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC33240 | |||
| ...YPVVN | 334 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| MMP2_MOUSE | 38 | HRRL.|.LYGT | inferred from experiment | unknown | MEROPS | Overall CM | auf dem Keller U et al.:A statistics-based platform for... (M10.003) | 20305283, |
| MMP2_MOUSE | 76 | SMEM.|.MNAF | inferred from experiment | unknown | MEROPS | Merops MMP2_MOUSE -> CATL1_MOUSE @76 | ||
| MMP2_MOUSE | 240 | AVAT.|.TVGP | inferred from experiment | unknown | MEROPS | Merops MMP2_MOUSE -> CATL1_MOUSE @240 | ||
| CATE_MOUSE | 310 | MEGY.|.YIKI | inferred from experiment | unknown | MEROPS | Merops CATE_MOUSE -> CATL1_MOUSE @310 | ||
| MMP2_MOUSE | 318 | KDRD.|.DNHC | inferred from experiment | unknown | MEROPS | Merops MMP2_MOUSE -> CATL1_MOUSE @318 |
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| H31_MOUSE | 22 | QLAT.|.TKAA | inferred from experiment | unknown | MEROPS | Allis CD | Duncan EM et al.:Cathepsin L proteolytically pro... (C01.032) | 18957203, |
| H31_MOUSE | 23 | LATK.|.KAAR | inferred from experiment | unknown | MEROPS | Allis CD | Duncan EM et al.:Cathepsin L proteolytically pro... (C01.032) | 18957203, |
| H31_MOUSE | 24 | ATKA.|.AARK | inferred from experiment | unknown | MEROPS | Allis CD | Duncan EM et al.:Cathepsin L proteolytically pro... (C01.032) | 18957203, |
| H31_MOUSE | 25 | TKAA.|.ARKS | inferred from experiment | unknown | MEROPS | Allis CD | Duncan EM et al.:Cathepsin L proteolytically pro... (C01.032) | 18957203, |
| H31_MOUSE | 27 | AARK.|.KSAP | inferred from experiment | unknown | MEROPS | Allis CD | Duncan EM et al.:Cathepsin L proteolytically pro... (C01.032) | 18957203, |
| H31_MOUSE | 28 | ARKS.|.SAPA | inferred from experiment | unknown | MEROPS | Allis CD | Duncan EM et al.:Cathepsin L proteolytically pro... (C01.032) | 18957203, |
| H31_MOUSE | 37 | GVKK.|.KPHR | inferred from experiment | unknown | MEROPS | Allis CD | Duncan EM et al.:Cathepsin L proteolytically pro... (C01.032) | 18957203, |
| BID_MOUSE | 65 | ASRS.|.SFNQ | inferred from experiment | unknown | MEROPS | Turk B | Cirman T et al.:Selective disruption of lysosom... (C01.040) | 14581476, |
| DYN1_MOUSE | 360 | GGAR.|.RINR | inferred from experiment | unknown | MEROPS | Reiser J | Sever S et al.:Proteolytic processing of dynam... (C01.032) | 17671649, |
| DYN1-Isoform6_MOUSE | 360 | GGAR.|.RINR | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC31410 | ||
| DYN1-Isoform5_MOUSE | 360 | GGAR.|.RINR | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC31410 | ||
| DYN1-Isoform4_MOUSE | 360 | GGAR.|.RINR | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC31410 | ||
| DYN1-Isoform3_MOUSE | 360 | GGAR.|.RINR | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC31410 | ||
| DYN1-Isoform2_MOUSE | 360 | GGAR.|.RINR | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC31410 |