Q91YR1: Twinfilin-1

General Information

Protein names	- Twinfilin-1 - Protein A6
Gene names	Twf1
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q91YR1

8 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSHQTGIQAS EDVKEIFARA RNGKYRLLKI SIENEQLVVG SCSPPSDSWE QDYDSFVLPL
        70         80         90        100        110        120
LEDKQPCYVL FRLDSQNAQG YEWIFIAWSP DHSHVRQKML YAATRATLKK EFGGGHIKDE
       130        140        150        160        170        180
VFGTVKEDVS LHGYKKYLLS QSSPAPLTAA EEELRQIKIN EVQTDVSVDT KHQTLQGVAF
       190        200        210        220        230        240
PISRDAFQAL EKLSKKQLNY VQLEIDIKNE TIILANTENT ELRDLPKRIP KDSARYHFFL
       250        260        270        280        290        300
YKHSHEGDYL ESVVFIYSMP GYTCSIRERM LYSSCKSPLL EIVERQLQMD VIRKIEIDNG
       310        320        330        340        350
DELTADFLYD EVHPKQHAHK QSFAKPKGPA GKRGIRRLIR GPAEAEATTD

Isoforms

Sequence View

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Evidence Names:

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Lab:

Protein Neighborhood

Domains & Features

8 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q91YR1-2-unknown	MSHQTG...	1		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q91YR1-2-unknown	MSHQTG...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q91YR1-2-Acetylation	SHQTGI...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q91YR1-2-Acetylation	SHQTGI...	2	acetylation-		N-TAILS		Overall CM.	Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies...	20208520
Q91YR1-2-Acetylation	SHQTGI...	2	acetylation-		N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
Q91YR1-2-Acetylation	SHQTGI...	2	acetylation-	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q91YR1-7-unknown	IQASED...	7		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34143
Q91YR1-54-unknown	DSFVLP...	54		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q91YR1-68-unknown	YVLFRL...	68		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q91YR1-147-unknown	LTAAEE...	147		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34635
Q91YR1-147-unknown	LTAAEE...	147		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34144
Q91YR1-166-unknown	VSVDTK...	166			N-TAILS		Overall CM.	auf dem Keller U.: A statistics-based platform for quantitative N-terminome...	20305283
Q91YR1-175-unknown	LQGVAF...	175		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34145

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SHQTGI	6	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34143
...KYLLSQ	140	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000119302
...SSPAPL	146	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34635
...SSPAPL	146	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34144
...TKHQTL	174	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34145
...EATTD	350	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	6	QTGI.\|.IQAS	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP9_MOUSE	146	PAPL.\|.LTAA	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,
MMP2_MOUSE	146	PAPL.\|.LTAA	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,
MMP2_MOUSE	174	HQTL.\|.LQGV	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)