Q6PDQ2: Chromodomain-helicase-DNA-binding protein 4

General Information

Protein names	- Chromodomain-helicase-DNA-binding protein 4 - CHD-4 - 3.6.4.12
Gene names	Chd4
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q6PDQ2

5 N-termini

5 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MASGLGSPSP CSAGSEEEDM DALLNNSLPP PHPENEEDPD EDLSEAETPK LKKKKKPKKP
        70         80         90        100        110        120
RDPKIPKSKR QKKELGDSSG EGPEFVEEEE EVALRSDSEG SDYTPGKKKK KKLGPKKEKK
       130        140        150        160        170        180
SKSKRKEEEE EEDEDDDSKE PKSSAQLLED WGMEDIDHVF SEEDYRTLTN YKAFSQFVRP
       190        200        210        220        230        240
LIAAKNPKIA VSKMMMVLGA KWREFSTNNP FKGSSGASVA AAAAAAVAVV ESMVTATEVA
       250        260        270        280        290        300
PPPPPVEVPI RKAKTKEGKG PNARRKPKGS PRVPDAKKPK PKKVAPLKIK LGGFGSKRKR
       310        320        330        340        350        360
SSSEDDDLDV ESDFDDASIN SYSVSDGSTS RSSRSRKKLR TAKKKKKGEE EVTAVDGYET
       370        380        390        400        410        420
DHQDYCEVCQ QGGEIILCDT CPRAYHMVCL DPDMEKAPEG KWSCPHCEKE GIQWEAKEDN
       430        440        450        460        470        480
SEGEEILEEV GGDPEEEDDH HMEFCRVCKD GGELLCCDTC PSSYHIHCLN PPLPEIPNGE
       490        500        510        520        530        540
WLCPRCTCPA LKGKVQKILI WKWGQPPSPT PVPRPPDADP NTPSPKPLEG RPERQFFVKW
       550        560        570        580        590        600
QGMSYWHCSW VSELQLELHC QVMFRNYQRK NDMDEPPSGD FGGDEEKSRK RKNKDPKFAE
       610        620        630        640        650        660
MEERFYRYGI KPEWMMIHRI LNHSVDKKGH VHYLIKWRDL PYDQASWESE DVEIQDYDLF
       670        680        690        700        710        720
KQSYWNHREL MRGEEGRPGK KLKKVKLRKL ERPPETPTVD PTVKYERQPE YLDATGGTLH
       730        740        750        760        770        780
PYQMEGLNWL RFSWAQGTDT ILADEMGLGK TVQTAVFLYS LYKEGHSKGP FLVSAPLSTI
       790        800        810        820        830        840
INWEREFEMW APDMYVVTYV GDKDSRAIIR ENEFSFEDNA IRGGKKASRM KKEASVKFHV
       850        860        870        880        890        900
LLTSYELITI DMAILGSIDW ACLIVDEAHR LKNNQSKFFR VLNGYSLQHK LLLTGTPLQN
       910        920        930        940        950        960
NLEELFHLLN FLTPERFHNL EGFLEEFADI AKEDQIKKLH DMLGPHMLRR LKADVFKNMP
       970        980        990       1000       1010       1020
SKTELIVRVE LSPMQKKYYK YILTRNFEAL NARGGGNQVS LLNVVMDLKK CCNHPYLFPV
      1030       1040       1050       1060       1070       1080
AAMEAPKMPN GMYDGSALIR ASGKLLLLQK MLKNLKEGGH RVLIFSQMTK MLDLLEDFLE
      1090       1100       1110       1120       1130       1140
HEGYKYERID GGITGNMRQE AIDRFNAPGA QQFCFLLSTR AGGLGINLAT ADTVIIYDSD
      1150       1160       1170       1180       1190       1200
WNPHNDIQAF SRAHRIGQNK KVMIYRFVTR ASVEERITQV AKKKMMLTHL VVRPGLGSKT
      1210       1220       1230       1240       1250       1260
GSMSKQELDD ILKFGTEELF KDEATDGGGD NKEGEDSSVI HYDDKAIERL LDRNQDETED
      1270       1280       1290       1300       1310       1320
TELQGMNEYL SSFKVAQYVV REEEMGEEEE VEREIIKQEE SVDPDYWEKL LRHHYEQQQE
      1330       1340       1350       1360       1370       1380
DLARNLGKGK RIRKQVNYND GSQEDRDWQD DQSDNQSDYS VASEEGDEDF DERSEAPRRP
      1390       1400       1410       1420       1430       1440
SRKGLRNDKD KPLPPLLARV GGNIEVLGFN ARQRKAFLNA IMRYGMPPQD AFTTQWLVRD
      1450       1460       1470       1480       1490       1500
LRGKSEKEFK AYVSLFMRHL CEPGADGAET FADGVPREGL SRQHVLTRIG VMSLIRKKVQ
      1510       1520       1530       1540       1550       1560
EFEHVNGRWS MPELAEVEEN KKMSQPGSPS PKTPTPSTPG DTQPNTPAPV PPAEDGIKIE
      1570       1580       1590       1600       1610       1620
ENSLKEEEST EGEKEVKSTA PEATVECAQP PAPAPATAPA TATAPEDDKA PAEPPEGEEK
      1630       1640       1650       1660       1670       1680
VEKAEVKERT EEPMETEAKG TTEVEKVEEK SAVDLTPIVV EDKEEKKEEE EKKDVMLQNG
      1690       1700       1710       1720       1730       1740
ETPKDLSDEK QKKNSKQRFM FNIADGGFTE LHSLWQNEER AATVTKKTYE IWHRRHDYWL
      1750       1760       1770       1780       1790       1800
LAGIINHGYA RWQDIQNDPR YAILNEPFKG EMNRGNFLEI KNKFLARRFK LLEQALVIEE
      1810       1820       1830       1840       1850       1860
QLRRAAYLNM SEDPSHPSMA LNTRFAEVEC LAESHQHLSK ESMAGNKPAN AVLHKVLKQL
      1870       1880       1890       1900       1910
EELLSDMKAD VTRLPATIAR IPPVAVRLQM SERNILSRLA NRAPEPPPQQ VAQQQ

Isoforms

Sequence View

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Protease Assignment Confidence:

Evidence Names:

Database:

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Protein Neighborhood

Domains & Features

5 N-termini - 5 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q6PDQ2-1-unknown	MASGLG...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q6PDQ2-78-unknown	SSGEGP...	78	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC32480
Q6PDQ2-1142-unknown	NPHNDI...	1142	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSMUSP00000120704
Q6PDQ2-1227-unmodified	GGGDNK...	1227		N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
Q6PDQ2-1273-unknown	FKVAQY...	1273	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34026

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ETPKLK	51	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000122806
...KELGDS	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32480
...EYLSSF	1272	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34026
...AEDGIK	1557	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000120704
...VAQQQ	1915	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_MOUSE	77	LGDS.\|.SSGE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
MMP2_MOUSE	1272	LSSF.\|.FKVA	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)