Q04750: DNA topoisomerase 1

General Information

Protein names	- DNA topoisomerase 1 - 5.6.2.2 {ECO:0000255\|PROSITE-ProRule:PRU10130} - DNA topoisomerase I
Gene names	Top1
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q04750

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSGDHLHNDS QIEADFRLND SHKHKDKHKD REHRHKEHKK DKDKDREKSK HSNSEHKDSE
        70         80         90        100        110        120
KKHKEKEKTK HKDGSSEKHK DKHKDRDKER RKEEKIRAAG DAKIKKEKEN GFSSPPRIKD
       130        140        150        160        170        180
EPEDDGYFAP PKEDIKPLKR LRDEDDADYK PKKIKTEDIK KEKKRKSEEE EDGKLKKPKN
       190        200        210        220        230        240
KDKDKKVAEP DNKKKKPKKE EEQKWKWWEE ERYPEGIKWK FLEHKGPVFA PPYEPLPESV
       250        260        270        280        290        300
KFYYDGKVMK LSPKAEEVAT FFAKMLDHEY TTKEIFRKNF FKDWRKEMTN DEKNTITNLS
       310        320        330        340        350        360
KCDFTQMSQY FKAQSEARKQ MSKEEKLKIK EENEKLLKEY GFCVMDNHRE RIANFKIEPP
       370        380        390        400        410        420
GLFRGRGNHP KMGMLKRRIM PEDIIINCSK DAKVPSPPPG HKWKEVRHDN KVTWLVSWTE
       430        440        450        460        470        480
NIQGSIKYIM LNPSSRIKGE KDWQKYETAR RLKKCVDKIR NQYREDWKSK EMKVRQRAVA
       490        500        510        520        530        540
LYFIDKLALR AGNEKEEGET ADTVGCCSLR VEHINLHPEL DGQEYVVEFD FPGKDSIRYY
       550        560        570        580        590        600
NKVPVEKRVF KNLQLFMENK QPEDDLFDRL NTGILNKHLQ DLMEGLTAKV FRTYNASITL
       610        620        630        640        650        660
QQQLKELTAP DENVPAKILS YNRANRAVAI LCNHQRAPPK TFEKSMMNLQ SKIDAKKDQL
       670        680        690        700        710        720
ADARRDLKSA KADAKVMKDA KTKKVVESKK KAVQRLEEQL MKLEVQATDR EENKQIALGT
       730        740        750        760
SKLNYLDPRI TVAWCKKWGV PIEKIYNKTQ REKFAWAIDM TDEDYEF

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q04750-2-unknown	MSGDHL...	1		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q04750-2-unknown	MSGDHL...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q04750-2-Acetylation	SGDHLH...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q04750-2-Acetylation	SGDHLH...	2	acetylation-	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q04750-9-unmodified	DSQIEA...	9			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
Q04750-265-unknown	MLDHEY...	265		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33892

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...TFFAKM	264	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33892
	...EDYEF	767	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	264	FAKM.\|.MLDH	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)