Q00493: Carboxypeptidase E

General Information

Protein names	- Carboxypeptidase E - CPE - 3.4.17.10 - Carboxypeptidase H - CPH - Enkephalin convertase - Prohormone-processing carboxypeptidase
Gene names	Cpe
Organism	Mus musculus
Protease Family
Protease ID	M14.005
Chromosome location
UniProt ID	Q00493

6 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAGRGGRVLL ALCAALVAGG WLLTAEAQEP GAPAAGMRRR RRLQQEDGIS FEYHRYPELR
        70         80         90        100        110        120
EALVSVWLQC TAISRIYTVG RSFEGRELLV IELSDNPGVH EPGEPEFKYI GNMHGNEAVG
       130        140        150        160        170        180
RELLIFLAQY LCNEYQKGNE TIVNLIHSTR IHIMPSLNPD GFEKAASQPG ELKDWFVGRS
       190        200        210        220        230        240
NAQGIDLNRN FPDLDRIVYV NEKEGGPNNH LLKNLKKIVD QNSKLAPETK AVIHWIMDIP
       250        260        270        280        290        300
FVLSANLHGG DLVANYPYDE TRSGTAHEYS SCPDDAIFQS LARAYSSFNP VMSDPNRPPC
       310        320        330        340        350        360
RKNDDDSSFV DGTTNGGAWY SVPGGMQDFN YLSSNCFEIT VELSCEKFPP EETLKSYWED
       370        380        390        400        410        420
NKNSLISYLE QIHRGVKGFV RDLQGNPIAN ATISVDGIDH DVTSAKDGDY WRLLAPGNYK
       430        440        450        460        470
LTASAPGYLA ITKKVAVPFS PAVGVDFELE SFSERKEEEK EELMEWWKMM SETLNF

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q00493-28-unknown	QEPGAP...	28	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q00493-28-unknown	QEPGAP...	28	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q00493-43-unknown	LQQEDG...	43	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q00493-43-unknown	LQQEDG...	43	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q00493-180-unmodified	SNAQGI...	180		N-TAILS		Overall CM.	Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies...	20208520
Q00493-180-unknown	SNAQGI...	180	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33848
Q00493-252-unknown	LVANYP...	252	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33849
Q00493-391-unknown	ATISVD...	391	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33850
Q00493-391-unknown	ATISVD...	391	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...WFVGRS	179	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33848
...LHGGDL	251	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33849
...NPIANA	390	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33850
...ETLNF	476	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	179	VGRS.\|.SNAQ	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	251	GGDL.\|.LVAN	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	390	IANA.\|.ATIS	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)