Q8CIG8: Protein arginine N-methyltransferase 5

General Information

Protein names	- Protein arginine N-methyltransferase 5 - 2.1.1.320 {ECO:0000250\|UniProtKB:O14744} - Histone-arginine N-methyltransferase PRMT5 - Jak-binding protein 1 - Shk1 kinase-binding protein 1 homolog - SKB1 homolog
Gene names	Prmt5
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8CIG8

5 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAMAVGGAG GSRVSSGRDL NCVPEIADTL GAVAKQGFDF LCMPVFHPRF KREFIQEPAK
        70         80         90        100        110        120
NRPGPQTRSD LLLSGRDWNT LIVGKLSPWI HPDSKVEKIR RNSEAAMLQE LNFGAYLGLP
       130        140        150        160        170        180
AFLLPLNQED NTNLARVLTN HIHTGHHSSM FWMRVPLVAP EDLRDDVIAN APTTHTEEYS
       190        200        210        220        230        240
GEEKTWMWWH NFRTLCDYSK RIAVALEIGA DLPSNHVIDR WLGEPIKAAI LPTSIFLTNK
       250        260        270        280        290        300
KGFPVLSKVQ QRLIFRLLKL EVQFIITGTN HHSEKEFCSY LQYLEYLSQN RPPPNAYELF
       310        320        330        340        350        360
AKGYEDYLQS PLQPLMDNLE SQTYEVFEKD PIKYSQYQQA IYKCLLDRVP EEEKETNVQV
       370        380        390        400        410        420
LMVLGAGRGP LVNASLRAAK QAERRIRLYA VEKNPNAVVT LENWQFEEWG SQVTVVSSDM
       430        440        450        460        470        480
REWVAPEKAD IIVSELLGSF ADNELSPECL DGAQHFLKDD GVSIPGEYTS FLAPISSSKL
       490        500        510        520        530        540
YNEVRACREK DRDPEAQFEM PYVVRLHNFH QLSAPKPCFT FSHPNRDPMI DNNRYCTLEF
       550        560        570        580        590        600
PVEVNTVLHG FAGYFETVLY RDITLSIRPE THSPGMFSWF PIFFPIKQPI TVHEGQNICV
       610        620        630
RFWRCSNSKK VWYEWAVTAP VCSSIHNPTG RSYTIGL

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
Q8CIG8-2-unknown	MAAMAV...	1		inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
Q8CIG8-2-unknown	MAAMAV...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q8CIG8-2-Acetylation	AAMAVG...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q8CIG8-2-Acetylation	AAMAVG...	2	acetylation-	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
Q8CIG8-188-unknown	WWHNFR...	188		inferred from electronic annotation	unknown	TISdb	inferred from TISdb
Q8CIG8-190-unknown	HNFRTL...	190		inferred from electronic annotation	unknown	TISdb	inferred from TISdb
Q8CIG8-475-unknown	ISSSKL...	475		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34102

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VTVVSS	417	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000121502
...SFLAPI	474	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34102
...YTIGL	637	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	474	LAPI.\|.ISSS	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)