P10605: Cathepsin B

General Information

Protein names	- Cathepsin B - 3.4.22.1 {ECO:0000250\|UniProtKB:P07858} - Cathepsin B1 - Cathepsin B light chain {ECO:0000250\|UniProtKB:P07858} - Cathepsin B heavy chain {ECO:0000250\|UniProtKB:P07858}
Gene names	Ctsb
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P10605

13 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MWWSLILLSC LLALTSAHDK PSFHPLSDDL INYINKQNTT WQAGRNFYNV DISYLKKLCG
        70         80         90        100        110        120
TVLGGPKLPG RVAFGEDIDL PETFDAREQW SNCPTIGQIR DQGSCGSCWA FGAVEAISDR
       130        140        150        160        170        180
TCIHTNGRVN VEVSAEDLLT CCGIQCGDGC NGGYPSGAWS FWTKKGLVSG GVYNSHVGCL
       190        200        210        220        230        240
PYTIPPCEHH VNGSRPPCTG EGDTPRCNKS CEAGYSPSYK EDKHFGYTSY SVSNSVKEIM
       250        260        270        280        290        300
AEIYKNGPVE GAFTVFSDFL TYKSGVYKHE AGDMMGGHAI RILGWGVENG VPYWLAANSW
       310        320        330
NLDWGDNGFF KILRGENHCG IESEIVAGIP RTDQYWGRF

Isoforms

Sequence View

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Physiological Relevance:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

13 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P10605-18-unknown	HDKPSF...	18	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P10605-24-unknown	HPLSDD...	24	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P10605-38-unknown	NTTWQA...	38	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P10605-55-unknown	LKKLCG...	55	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33318
P10605-73-unmodified	AFGEDI...	73		N-TAILS		Overall CM.	Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies...	20208520
P10605-76-unknown	EDIDLP...	76		N-TAILS		Overall CM.	auf dem Keller U.: A statistics-based platform for quantitative N-terminome...	20305283
P10605-76-unmodified	EDIDLP...	76		N-TAILS		Overall CM.	Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies...	20208520
P10605-77-unknown	DIDLPE...	77		N-TAILS		Overall CM.	auf dem Keller U.: A statistics-based platform for quantitative N-terminome...	20305283
P10605-78-unmodified	IDLPET...	78		unknown			Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
P10605-80-unknown	LPETFD...	80	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P10605-82-unknown	ETFDAR...	82	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P10605-99-unknown	IRDQGS...	99	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33319
P10605-129-unknown	VNVEVS...	129	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VDISYL	54	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33318
...PTIGQI	98	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33319
...CIHTNG	126	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...IPRTDQ	333	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	54	ISYL.\|.LKKL	inferred from experiment	unknown	MEROPS		Merops MMP2_MOUSE -> CATB_MOUSE @54
MMP2_MOUSE	98	IGQI.\|.IRDQ	inferred from experiment	unknown	MEROPS		Merops MMP2_MOUSE -> CATB_MOUSE @98

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)