Q8VIJ6: Splicing factor, proline- and glutamine-rich

General Information

Protein names	- Splicing factor, proline- and glutamine-rich - DNA-binding p52/p100 complex, 100 kDa subunit - Polypyrimidine tract-binding protein-associated-splicing factor - PSF - PTB-associated-splicing factor
Gene names	Sfpq
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8VIJ6

6 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSRDRFRSRG GGGGGFHRRG GGGGRGGLHD FRSPPPGMGL NQNRGPMGPG PGGPKPPLPP
        70         80         90        100        110        120
PPPHQQQQQP PPQQPPPQQP PPHQQPPPHQ PPHQQPPPPP QESKPVVPQG PGSAPGVSSA
       130        140        150        160        170        180
PPPAVSAPPA NPPTTGAPPG PGPTPTPPPA VPSTAPGPPP PSTPSSGVST TPPQTGGPPP
       190        200        210        220        230        240
PPAGGAGPGP KPGPGPGGPK GGKMPGGPKP GGGPGMGAPG GHPKPPHRGG GEPRGGRQHH
       250        260        270        280        290        300
APYHQQHHQG PPPGGPGPRT EEKISDSEGF KANLSLLRRP GEKTYTQRCR LFVGNLPADI
       310        320        330        340        350        360
TEDEFKRLFA KYGEPGEVFI NKGKGFGFIK LESRALAEIA KAELDDTPMR GRQLRVRFAT
       370        380        390        400        410        420
HAAALSVRNL SPYVSNELLE EAFSQFGPIE RAVVIVDDRG RSTGKGIVEF ASKPAARKAF
       430        440        450        460        470        480
ERCSEGVFLL TTTPRPVIVE PLEQLDDEDG LPEKLAQKNP MYQKERETPP RFAQHGTFEY
       490        500        510        520        530        540
EYSQRWKSLD EMEKQQREQV EKNMKDAKDK LESEMEDAYH EHQANLLRQD LMRRQEELRR
       550        560        570        580        590        600
MEELHSQEMQ KRKEMQLRQE EERRRREEEM MIRQREMEEQ MRRQREESYS RMGYMDPRER
       610        620        630        640        650        660
DMRMGGGGTM NMGDPYGSGG QKFPPLGGGG GIGYEANPGV PPATMSGSMM GSDMRTERFG
       670        680        690
QGGAGPVGGQ GPRGMGPGTP AGYGRGREEY EGPNKKPRF

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8VIJ6-1-unknown	MSRDRF...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8VIJ6-335-unmodified	ALAEIA...	335		N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
Q8VIJ6-339-unknown	IAKAEL...	339	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34131
Q8VIJ6-392-unmodified	AVVIVD...	392		N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
Q8VIJ6-437-unknown	VIVEPL...	437	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34132
Q8VIJ6-660-unknown	GQGGAG...	660	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30875

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RALAEI	338	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34131
...TTPRPV	436	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34132
...RTERFG	659	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30875
...KKPRF	699	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	338	LAEI.\|.IAKA	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	436	PRPV.\|.VIVE	inferred from experiment	unknown	MEROPS		Merops MMP2_MOUSE -> SFPQ_MOUSE @436
CATE_MOUSE	659	ERFG.\|.GQGG	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> SFPQ_MOUSE @659

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)