P70168: Importin subunit beta-1

General Information

Protein names	- Importin subunit beta-1 - Karyopherin subunit beta-1 - Nuclear factor p97 - Pore targeting complex 97 kDa subunit - PTAC97 - SCG
Gene names	Kpnb1
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P70168

4 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MELITILEKT VSPDRLELEA AQKFLERAAV ENLPTFLVEL SRVLANPGNS QVARVAAGLQ
        70         80         90        100        110        120
IKNSLTSKDP DIKAQYQQRW LAIDANARRE VKNYVLQTLG TETYRPSSAS QCVAGIACAE
       130        140        150        160        170        180
IPVSQWPELI PQLVANVTNP NSTEHMKEST LEAIGYICQD IDPEQLQDKS NEILTAIIQG
       190        200        210        220        230        240
MRKEEPSNNV KLAATNALLN SLEFTKANFD KESERHFIMQ VVCEATQCPD TRVRVAALQN
       250        260        270        280        290        300
LVKIMSLYYQ YMETYMGPAL FAITIEAMKS DIDEVALQGI EFWSNVCDEE MDLAIEASEA
       310        320        330        340        350        360
AEQGRPPEHT SKFYAKGALQ YLVPILTQTL TKQDENDDDD DWNPCKAAGV CLMLLSTCCE
       370        380        390        400        410        420
DDIVPHVLPF IKEHIKNPDW RYRDAAVMAF GSILEGPEPN QLKPLVIQAM PTLIELMKDP
       430        440        450        460        470        480
SVVVRDTTAW TVGRICELLP EAAINDVYLA PLLQCLIEGL SAEPRVASNV CWAFSSLAEA
       490        500        510        520        530        540
AYEAADVADD QEEPATYCLS SSFELIVQKL LETTDRPDGH QNNLRSSAYE SLMEIVKNSA
       550        560        570        580        590        600
KDCYPAVQKT TLVIMERLQQ VLQMESHIQS TSDRIQFNDL QSLLCATLQN VLRKVQHQDA
       610        620        630        640        650        660
LQISDVVMAS LLRMFQSTAG SGGVQEDALM AVSTLVEVLG GEFLKYMEAF KPFLGIGLKN
       670        680        690        700        710        720
YAEYQVCLAA VGLVGDLCRA LQSNILPFCD EVMQLLLENL GNENVHRSVK PQILSVFGDI
       730        740        750        760        770        780
ALAIGGEFKK YLEVVLNTLQ QASQAQVDKS DFDMVDYLNE LRESCLEAYT GIVQGLKGDQ
       790        800        810        820        830        840
ENVHPDVMLV QPRVEFILSF IDHIAGDEDH TDGVVACAAG LIGDLCTAFG KDVLKLVEAR
       850        860        870
PMIHELLTEG RRSKTNKAKT LATWATKELR KLKNQA

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

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Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P70168-1-Acetylation	MELITI...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P70168-1-Acetylation	MELITI...	1	acetylation-		N-TAILS		Overall CM.	Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies...	20208520
P70168-16-unknown	LELEAA...	16		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33787
P70168-65-unknown	LTSKDP...	65		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33788
P70168-842-unknown	MIHELL...	842		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33789

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VSPDRL	15	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33787
...QIKNSL	64	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33788
...VEARPM	841	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33789
...LKNQA	876	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	15	PDRL.\|.LELE	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	64	KNSL.\|.LTSK	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
MMP2_MOUSE	841	ARPM.\|.MIHE	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)