Q9ESX5: H/ACA ribonucleoprotein complex subunit DKC1

General Information

Protein names	- H/ACA ribonucleoprotein complex subunit DKC1 - 5.4.99.- {ECO:0000250\|UniProtKB:O60832} - Dyskerin - Nopp140-associated protein of 57 kDa - Nucleolar protein NAP57 - Nucleolar protein family A member 4 - snoRNP protein DKC1
Gene names	Dkc1
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9ESX5

5 N-termini

5 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MADAEVITFP KKHKKKKDRK PLQEDDVAEI QHAEEFLIKP ESKVAQLDTS QWPLLLKNFD
        70         80         90        100        110        120
KLNVRTAHYT PLPCGSNPLK REIGDYIRTG FINLDKPSNP SSHEVVAWIR RILRVEKTGH
       130        140        150        160        170        180
SGTLDPKVTG CLIVCIERAT RLVKSQQSAG KEYVGIVRLH NAIEGGTQLS RALETLTGAL
       190        200        210        220        230        240
FQRPPLIAAV KRQLRVRTIY ESKMIEYDPE RRLGIFWVSC EAGTYIRTLC VHLGLLLGVG
       250        260        270        280        290        300
GQMQELRRVR SGVMSEKDHM VTMHDVLDAQ WLYDNHKDES YLRRVVYPLE KLLTSHKRLV
       310        320        330        340        350        360
MKDSAVNAIC YGAKIMLPGL LRYEDGIEVN QEIVVITTKG EAICMAIALM TTAVISTCDH
       370        380        390        400        410        420
GIVAKIKRVI MERDTYPRKW GLGPKASQKK MMIKQGLLDK HGKPTDNTPA TWKQDYIDYS
       430        440        450        460        470        480
DSGKNTLVTE AVQAPQLAAE AVNVIKRKRD SESESDETPT VPQLKEKKKK KDKKPKTVLE
       490        500
SGGETGDGDN DTTKKKKKKK VKVVEEMSE

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 5 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
Q9ESX5-2-unknown	MADAEV...	1		inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
Q9ESX5-2-unknown	MADAEV...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9ESX5-2-Acetylation	ADAEVI...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9ESX5-2-Acetylation	ADAEVI...	2	acetylation-	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
Q9ESX5-125-unknown	DPKVTG...	125		inferred from electronic annotation	unknown	TISdb	inferred from TISdb
Q9ESX5-431-unknown	AVQAPQ...	431		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32577
Q9ESX5-436-unknown	QLAAEA...	436		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34305

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DPKVTG	129	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000121957
...HKRLVM	300	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000120441
...TLVTEA	430	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32577
...AVQAPQ	435	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34305
...EEMSE	509	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_MOUSE	430	VTEA.\|.AVQA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
MMP2_MOUSE	435	QAPQ.\|.QLAA	inferred from experiment	unknown	MEROPS		Merops MMP2_MOUSE -> DKC1_MOUSE @435

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)