Q3UHU5: Microtubule cross-linking factor 1
| Protein names | - Microtubule cross-linking factor 1 - Coiled-coil domain-containing protein 165 - PAR-1-interacting protein - SOGA family member 2 |
|---|---|
| Gene names | Mtcl1 |
| Organism | Mus musculus |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | Q3UHU5 |
3
N-termini
2
C-termini
1
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
METLNGPAGG GAPDTKPQPA GQHHRHHHLH PLAERRRLHR APSPARPFLK DLHTRPATAT
70 80 90 100 110 120
PSAGRAPTPA APRSPSLAGK APPSPGPPAA PGRLSRRSGV VPGAKDKPPP GAGARSAGGA
130 140 150 160 170 180
KAVPGTRRAA RAGPAEPLSR VGRPTGAEPP PAVAKGRKTK RGPGTPPARA VVPPARASRV
190 200 210 220 230 240
PAVTLSVTSV AGCRINHTDS SSDLSDCASE PLSDEQRLLP AASSDAESGT GSSDREPIRG
250 260 270 280 290 300
APTPSSGSRG PPPGSPEPPI LLAAPPVASA CLGGRSSPGG ASTGSPGPGS QEDVGGRAPP
310 320 330 340 350 360
ERTILGTSKE PSLGEQPRLL VVAEEEELLR EMEELRSEND YLKDELDELR AEMEEMRDSY
370 380 390 400 410 420
LEEDGYQLQE LRRELDRANK NCRILQYRLR KAEQKSLKVA ETGQVDGELI RSLEQDLKVA
430 440 450 460 470 480
KDVSVRLHHE LETVEEKRAK AEDDNETLRQ QMIEVEVSRQ ALQNEVERLR ESSLKRRGSR
490 500 510 520 530 540
EMYKEKKLVN QDDSADLKCQ LQFVKEEASL MRKKMAKLGR EKDELEQELQ KYKSLYGDVD
550 560 570 580 590 600
SPLPTGEAGG PPSTREAELK LRLKLVEEEA SILGRKIVEL EVENRGLKAE MEDIRVQHER
610 620 630 640 650 660
EGTGRDHVPS TPTSPFGDSM ESSTELRRHL QFVEEEAELL RRSISEIEDH NRQLTHELSK
670 680 690 700 710 720
FKFEPHQESG WLGDGVSKGP AASVPLQEEL KSARLQIDEL SGKVLKLQCE NRLLLSNAQR
730 740 750 760 770 780
GDLAAHLGLR APSPRDSDAE SDAGKKESDG EEGRLPQPKR EGPVGGESDS EDMFEKTSGF
790 800 810 820 830 840
GSGKPSEASE PCPAELLRVR EDTECLVTIK LEAQRLERTV ERLISDTDGF IHDSGLRGNG
850 860 870 880 890 900
LASPGVQGGG GEGNSPSEPH LLETINVRMK AFRKELQAFL EQMSRIVDGL SPLSHLTESS
910 920 930 940 950 960
SFLSTVTSVS RDSPIGTLGK ELGPDLQSKL REQLEWQLNQ DRGDEREGLR LRATRELHRR
970 980 990 1000 1010 1020
ADGDSGSHHG LGGQSCFNLE MEEDHLYALR WKELEMHSLA LQNTLHKRTW SDEKNLLQQE
1030 1040 1050 1060 1070 1080
LRSLKQNIFL FYVKLRWLLK HWRQGKQMEE GGEDLEESEH PENVPGLAEL GVQGVHQTDG
1090 1100 1110 1120 1130 1140
IDQEDADQGC SLPMGEHAPH SLVQISEHGS RLQSSDGGPL NKQVVENQQL FRALKALLED
1150 1160 1170 1180 1190 1200
FRSELREDEH ARLRLQQQYA SDKAAWDVEW AVLKCRLEQL EEKTEKSLGE LDSSAEGKGA
1210 1220 1230 1240 1250 1260
LKKEREVHQK LLADSHSLVM DLRWQIHHRE KNWNREKVEL LERLDSERQE WGRQKEELLW
1270 1280 1290 1300 1310 1320
RVEQLQKEKS PRRSGSFLCS RREDDTRPYP HQGSLHSSRP VSMWPCEDAD SIPFEDRPLS
1330 1340 1350 1360 1370 1380
KLKESDRCSA SENLYLDALS LDDDPGDPPP LRNCLAEEEE SRKGNLQRAV SVSCMSEFQR
1390 1400 1410 1420 1430 1440
LMDVSPFLPE KGLPSAGSKE DVTPPLSPDD LKYIEEFHSN DWDYASPRAE ADRPPDPWAD
1450 1460 1470 1480 1490 1500
RTEMGRVGHE ATTEPCPDPS WYLTTSVTMT TDTMTSPEHC QKQPLRTHVL TEQSGVHVLH
1510 1520 1530 1540 1550 1560
SPPAIRRVDS IASGGEGRSR ADPEGPFPMS RARGNLADAK GGHPEPVLNR WPCTPPRHPR
1570 1580 1590 1600 1610 1620
DCVEGSLRPL DRPICPSLGF ASPLNSLDMS KNMSDDMKEV AFSVRNAICA GPAEPHVRDM
1630 1640 1650 1660 1670 1680
ACQTNGSRTA GTQTIQTISV GLQTEALRAS GVTSSPHKCL TPKAGGGTTP VSSPSRSLRS
1690 1700 1710 1720 1730 1740
RQVAPAIEKV QAKFERTCCS PKYGSPKLQR KPLSKADQPN SRTSPGIPQK GFSESAWARS
1750 1760 1770 1780 1790 1800
TTTRESPVHT TINDGLSSLF NIIDHSPIGV RAGSRSRSAE PRQELGPGQE TGTSSRGRSP
1810 1820 1830 1840 1850 1860
SPLGVGSETF REEGGESTPV RQDLSAPPGY TLTENVARIL NKKLLEHALK EERKQASHGS
1870 1880 1890 1900 1910 1920
SGLTSDSHTG EPVPAEPGSM EELPCSALAP SLEPCFSRPE RPANRRLPSR WAPPSPTASQ
1930 1940
SQSPGHPMSM EEHGEEDPPE EKPHL
Isoforms
- Isoform 2 of Microtubule cross-linking factor 1 - Isoform 3 of Microtubule cross-linking factor 1Sequence View
10 20 30 40 50 60
METLNGPAGG GAPDTKPQPA GQHHRHHHLH PLAERRRLHR APSPARPFLK DLHTRPATAT
70 80 90 100 110 120
PSAGRAPTPA APRSPSLAGK APPSPGPPAA PGRLSRRSGV VPGAKDKPPP GAGARSAGGA
130 140 150 160 170 180
KAVPGTRRAA RAGPAEPLSR VGRPTGAEPP PAVAKGRKTK RGPGTPPARA VVPPARASRV
190 200 210 220 230 240
PAVTLSVTSV AGCRINHTDS SSDLSDCASE PLSDEQRLLP AASSDAESGT GSSDREPIRG
250 260 270 280 290 300
APTPSSGSRG PPPGSPEPPI LLAAPPVASA CLGGRSSPGG ASTGSPGPGS QEDVGGRAPP
310 320 330 340 350 360
ERTILGTSKE PSLGEQPRLL VVAEEEELLR EMEELRSEND YLKDELDELR AEMEEMRDSY
370 380 390 400 410 420
LEEDGYQLQE LRRELDRANK NCRILQYRLR KAEQKSLKVA ETGQVDGELI RSLEQDLKVA
430 440 450 460 470 480
KDVSVRLHHE LETVEEKRAK AEDDNETLRQ QMIEVEVSRQ ALQNEVERLR ESSLKRRGSR
490 500 510 520 530 540
EMYKEKKLVN QDDSADLKCQ LQFVKEEASL MRKKMAKLGR EKDELEQELQ KYKSLYGDVD
550 560 570 580 590 600
SPLPTGEAGG PPSTREAELK LRLKLVEEEA SILGRKIVEL EVENRGLKAE MEDIRVQHER
610 620 630 640 650 660
EGTGRDHVPS TPTSPFGDSM ESSTELRRHL QFVEEEAELL RRSISEIEDH NRQLTHELSK
670 680 690 700 710 720
FKFEPHQESG WLGDGVSKGP AASVPLQEEL KSARLQIDEL SGKVLKLQCE NRLLLSNAQR
730 740 750 760 770 780
GDLAAHLGLR APSPRDSDAE SDAGKKESDG EEGRLPQPKR EGPVGGESDS EDMFEKTSGF
790 800 810 820 830 840
GSGKPSEASE PCPAELLRVR EDTECLVTIK LEAQRLERTV ERLISDTDGF IHDSGLRGNG
850 860 870 880 890 900
LASPGVQGGG GEGNSPSEPH LLETINVRMK AFRKELQAFL EQMSRIVDGL SPLSHLTESS
910 920 930 940 950 960
SFLSTVTSVS RDSPIGTLGK ELGPDLQSKL REQLEWQLNQ DRGDEREGLR LRATRELHRR
970 980 990 1000 1010 1020
ADGDSGSHHG LGGQSCFNLE MEEDHLYALR WKELEMHSLA LQNTLHKRTW SDEKNLLQQE
1030 1040 1050 1060 1070 1080
LRSLKQNIFL FYVKLRWLLK HWRQGKQMEE GGEDLEESEH PENVPGLAEL GVQGVHQTDG
1090 1100 1110 1120 1130 1140
IDQEDADQGC SLPMGEHAPH SLVQISEHGS RLQSSDGGPL NKQVVENQQL FRALKALLED
1150 1160 1170 1180 1190 1200
FRSELREDEH ARLRLQQQYA SDKAAWDVEW AVLKCRLEQL EEKTEKSLGE LDSSAEGKGA
1210 1220 1230 1240 1250 1260
LKKEREVHQK LLADSHSLVM DLRWQIHHRE KNWNREKVEL LERLDSERQE WGRQKEELLW
1270 1280 1290 1300 1310 1320
RVEQLQKEKS PRRSGSFLCS RREDDTRPYP HQGSLHSSRP VSMWPCEDAD SIPFEDRPLS
1330 1340 1350 1360 1370 1380
KLKESDRCSA SENLYLDALS LDDDPGDPPP LRNCLAEEEE SRKGNLQRAV SVSCMSEFQR
1390 1400 1410 1420 1430 1440
LMDVSPFLPE KGLPSAGSKE DVTPPLSPDD LKYIEEFHSN DWDYASPRAE ADRPPDPWAD
1450 1460 1470 1480 1490 1500
RTEMGRVGHE ATTEPCPDPS WYLTTSVTMT TDTMTSPEHC QKQPLRTHVL TEQSGVHVLH
1510 1520 1530 1540 1550 1560
SPPAIRRVDS IASGGEGRSR ADPEGPFPMS RARGNLADAK GGHPEPVLNR WPCTPPRHPR
1570 1580 1590 1600 1610 1620
DCVEGSLRPL DRPICPSLGF ASPLNSLDMS KNMSDDMKEV AFSVRNAICA GPAEPHVRDM
1630 1640 1650 1660 1670 1680
ACQTNGSRTA GTQTIQTISV GLQTEALRAS GVTSSPHKCL TPKAGGGTTP VSSPSRSLRS
1690 1700 1710 1720 1730 1740
RQVAPAIEKV QAKFERTCCS PKYGSPKLQR KPLSKADQPN SRTSPGIPQK GFSESAWARS
1750 1760 1770 1780 1790 1800
TTTRESPVHT TINDGLSSLF NIIDHSPIGV RAGSRSRSAE PRQELGPGQE TGTSSRGRSP
1810 1820 1830 1840 1850 1860
SPLGVGSETF REEGGESTPV RQDLSAPPGY TLTENVARIL NKKLLEHALK EERKQASHGS
1870 1880 1890 1900 1910 1920
SGLTSDSHTG EPVPAEPGSM EELPCSALAP SLEPCFSRPE RPANRRLPSR WAPPSPTASQ
1930 1940
SQSPGHPMSM EEHGEEDPPE EKPHL
10 20 30 40 50 60
METLNGPAGG GAPDTKPQPA GQHHRHHHLH PLAERRRLHR APSPARPFLK DLHTRPATAT
70 80 90 100 110 120
PSAGRAPTPA APRSPSLAGK APPSPGPPAA PGRLSRRSGV VPGAKDKPPP GAGARSAGGA
130 140 150 160 170 180
KAVPGTRRAA RAGPAEPLSR VGRPTGAEPP PAVAKGRKTK RGPGTPPARA VVPPARASRV
190 200 210 220 230 240
PAVTLSVTSV AGCRINHTDS SSDLSDCASE PLSDEQRLLP AASSDAESGT GSSDREPIRG
250 260 270 280 290 300
APTPSSGSRG PPPGSPEPPI LLAAPPVASA CLGGRSSPGG ASTGSPGPGS QEDVGGRAPP
310 320 330 340 350 360
ERTILGTSKE PSLGEQPRLL VVAEEEELLR EMEELRSEND YLKDELDELR AEMEEMRDSY
370 380 390 400 410 420
LEEDGYQLQE LRRELDRANK NCRILQYRLR KAEQKSLKVA ETGQVDGELI RSLEQDLKVA
430 440 450 460 470 480
KDVSVRLHHE LETVEEKRAK AEDDNETLRQ QMIEVEVSRQ ALQNEVERLR ESSLKRRGSR
490 500 510 520 530 540
EMYKEKKLVN QDDSADLKCQ LQFVKEEASL MRKKMAKLGR EKDELEQELQ KYKSLYGDVD
550 560 570 580 590 600
SPLPTGEAGG PPSTREAELK LRLKLVEEEA SILGRKIVEL EVENRGLKAE MEDIRVQHER
610 620 630 640 650 660
EGTGRDHVPS TPTSPFGDSM ESSTELRRHL QFVEEEAELL RRSISEIEDH NRQLTHELSK
670 680 690 700 710 720
FKFEPHQESG WLGDGVSKGP AASVPLQEEL KSARLQIDEL SGKVLKLQCE NRLLLSNAQR
730 740 750 760 770 780
GDLAAHLGLR APSPRDSDAE SDAGKKESDG EEGRLPQPKR EGPVGGESDS EDMFEKTSGF
790 800 810 820 830 840
GSGKPSEASE PCPAELLRVR EDTECLVTIK LEAQRLERTV ERLISDTDGF IHDSGLRGNG
850 860 870 880 890 900
LASPGVQGGG GEGNSPSEPH LLETINVRMK AFRKELQAFL EQMSRIVDGL SPLSHLTESS
910 920 930 940 950 960
SFLSTVTSVS RDSPIGTLGK ELGPDLQSKL REQLEWQLNQ DRGDEREGLR LRATRELHRR
970 980 990 1000 1010 1020
ADGDSGSHHG LGGQSCFNLE MEEDHLYALR WKELEMHSLA LQNTLHKRTW SDEKNLLQQE
1030 1040 1050 1060 1070 1080
LRSLKQNIFL FYVKLRWLLK HWRQGKQMEE GGEDLEESEH PENVPGLAEL GVQGVHQTDG
1090 1100 1110 1120 1130 1140
IDQEDADQGC SLPMGEHAPH SLVQISEHGS RLQSSDGGPL NKQVVENQQL FRALKALLED
1150 1160 1170 1180 1190 1200
FRSELREDEH ARLRLQQQYA SDKAAWDVEW AVLKCRLEQL EEKTEKSLGE LDSSAEGKGA
1210 1220 1230 1240 1250 1260
LKKEREVHQK LLADSHSLVM DLRWQIHHRE KNWNREKVEL LERLDSERQE WGRQKEELLW
1270 1280 1290 1300 1310 1320
RVEQLQKEKS PRRSGSFLCS RREDDTRPYP HQGSLHSSRP VSMWPCEDAD SIPFEDRPLS
1330 1340 1350 1360 1370 1380
KLKESDRCSA SENLYLDALS LDDDPGDPPP LRNCLAEEEE SRKGNLQRAV SVSCMSEFQR
1390 1400 1410 1420 1430 1440
LMDVSPFLPE KGLPSAGSKE DVTPPLSPDD LKYIEEFHSN DWDYASPRAE ADRPPDPWAD
1450 1460 1470 1480 1490 1500
RTEMGRVGHE ATTEPCPDPS WYLTTSVTMT TDTMTSPEHC QKQPLRTHVL TEQSGVHVLH
1510 1520 1530 1540 1550 1560
SPPAIRRVDS IASGGEGRSR ADPEGPFPMS RARGNLADAK GGHPEPVLNR WPCTPPRHPR
1570 1580 1590 1600 1610 1620
DCVEGSLRPL DRPICPSLGF ASPLNSLDMS KNMSDDMKEV AFSVRNAICA GPAEPHVRDM
1630 1640 1650 1660 1670 1680
ACQTNGSRTA GTQTIQTISV GLQTEALRAS GVTSSPHKCL TPKAGGGTTP VSSPSRSLRS
1690 1700 1710 1720 1730 1740
RQVAPAIEKV QAKFERTCCS PKYGSPKLQR KPLSKADQPN SRTSPGIPQK GFSESAWARS
1750 1760 1770 1780 1790 1800
TTTRESPVHT TINDGLSSLF NIIDHSPIGV RAGSRSRSAE PRQELGPGQE TGTSSRGRSP
1810 1820 1830 1840 1850 1860
SPLGVGSETF REEGGESTPV RQDLSAPPGY TLTENVARIL NKKLLEHALK EERKQASHGS
1870 1880 1890 1900 1910 1920
SGLTSDSHTG EPVPAEPGSM EELPCSALAP SLEPCFSRPE RPANRRLPSR WAPPSPTASQ
1930 1940
SQSPGHPMSM EEHGEEDPPE EKPHL
Protein Neighborhood
Domains & Features
3 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| Q3UHU5-1-unknown | METLNG... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| Q3UHU5-1-unknown | METLNG... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt81708 | |||
| Q3UHU5-320-unknown | LVVAEE... | 320 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC33912 | |||
| Q3UHU5-320-unknown | LVVAEE... | 320 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt150336 | |||
| Q3UHU5-515-unknown | MAKLGR... | 515 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt81707 | |||
| Q3UHU5-515-unknown | MAKLGR... | 515 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt98311 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...EQPRLL | 319 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC33912 | |||
| ...EQPRLL | 319 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt133732 | |||
| ...EKPHL | 1945 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| ...EKPHL | 1945 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt77325 |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| MMP2_MOUSE | 319 | PRLL.|.LVVA | inferred from experiment | unknown | MEROPS | Overall CM | auf dem Keller U et al.:A statistics-based platform for... (M10.003) | 20305283, |
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|