P45376: Aldo-keto reductase family 1 member B1

General Information

Protein names	- Aldo-keto reductase family 1 member B1 - 1.1.1.300 {ECO:0000250\|UniProtKB:P15121} - 1.1.1.372 {ECO:0000250\|UniProtKB:P15121} - 1.1.1.54 {ECO:0000250\|UniProtKB:P15121} - Aldehyde reductase - Aldo-keto reductase family 1 member B3 {ECO:0000312\|MGI:MGI:1353494} - Aldose reductase - AR - 1.1.1.21 {ECO:0000269\|PubMed:7851421}
Gene names	Akr1b1
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P45376

5 N-termini

5 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MASHLELNNG TKMPTLGLGT WKSPPGQVTE AVKVAIDLGY RHIDCAQVYQ NEKEVGVALQ
        70         80         90        100        110        120
EKLKEQVVKR QDLFIVSKLW CTFHDKSMVK GAFQKTLSDL QLDYLDLYLI HWPTGFKPGP
       130        140        150        160        170        180
DYFPLDASGN VIPSDTDFVD TWTAMEQLVD EGLVKTIGVS NFNPLQIERI LNKPGLKYKP
       190        200        210        220        230        240
AVNQIECHPY LTQEKLIEYC HSKGIVVTAY SPLGSPDRPW AKPEDPSLLE DPRIKAIAAK
       250        260        270        280        290        300
YNKTTAQVLI RFPIQRNLVV IPKSVTPVRI AENLKVFDFE VSSEDMATLL SYNRNWRVCA
       310
LMSCAKHKDY PFHAEV

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 5 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
P45376-2-unknown	MASHLE...	1		inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P45376-2-unknown	MASHLE...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P45376-2-Acetylation	ASHLEL...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P45376-2-Acetylation	ASHLEL...	2	acetylation-	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
P45376-157-unknown	IGVSNF...	157		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33561
P45376-259-unknown	VVIPKS...	259		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29956
P45376-280-unknown	EVSSED...	280		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29957

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VDEGLV	153	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000114391
...GLVKTI	156	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33561
...IQRNLV	258	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29956
...KVFDFE	279	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC29957
...FHAEV	316	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	156	VKTI.\|.IGVS	inferred from experiment	unknown	MEROPS	Overall CM	auf dem Keller U et al.:A statistics-based platform for... (M10.003)	20305283,
CATE_MOUSE	258	RNLV.\|.VVIP	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ALDR_MOUSE @258
CATE_MOUSE	279	FDFE.\|.EVSS	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ALDR_MOUSE @279

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)