Q8CIB5: Fermitin family homolog 2

General Information

Protein names	- Fermitin family homolog 2 - Kindlin-2 - Pleckstrin homology domain-containing family C member 1
Gene names	Fermt2
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8CIB5

6 N-termini

4 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MALDGIRMPD GCYADGTWEL SVHVTDLNRD VTLRVTGEVH IGGVMLKLVE KLDVKKDWSD
        70         80         90        100        110        120
HALWWEKKRT WLLKTHWTLD KCGIQADAKL QFTPQHKLLR LQLPNMKYVK VKVNFSDRVF
       130        140        150        160        170        180
KAVSDICKTF NIRHPEELSL LKKPRDPTKK KKKKLDDQSE DEALELEGPL IMPGSGSIYS
       190        200        210        220        230        240
SPGLYSKTMT PTYDAHDGSP LSPTSAWFGD SALSEGNPGI LAVSQPVTSP EILAKMFKPQ
       250        260        270        280        290        300
ALLDKAKTNQ GWLDSSRSLM EQDVKENEAL LLRFKYYSFF DLNPKYDAIR INQLYEQAKW
       310        320        330        340        350        360
ALLLEEIECT EEEMMMFAAL QYHINKLSIM TSENHLNNSD KEVDEVDAAL SDLEITLEGG
       370        380        390        400        410        420
KTSTILGDIT SIPELADYIK VFKPKKLTLK GYKQYWCTFK DTSISCYKSR EESSGTPAHQ
       430        440        450        460        470        480
LNLRGCEVTP DVNISGQKFN IKLLIPVAEG MNEIWLRCDN EKQYAHWMAA CRLASKGKTM
       490        500        510        520        530        540
ADSSYNLEVQ NILSFLKMQH LNPDPQLIPD QITTDVNPEC LVSPRYLKKY KSKQITARIL
       550        560        570        580        590        600
EAHQNVAQMS LIEAKMRFIQ AWQSLPEFGI THFIARFQGG KREELIGIAY NRLIRMDAST
       610        620        630        640        650        660
GDAIKTWRFS NMKQWNVNWE IKMVTVEFAD EVRLSFICTE VDCKVVHEFI GGYIFLSTRA
       670        680
KDQNESLDEE MFYKLTSGWV

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Evidence Names:

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Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8CIB5-1-unknown	MALDGI...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8CIB5-10-unknown	DGCYAD...	10	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q8CIB5-113-unknown	VNFSDR...	113	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q8CIB5-122-unmodified	AVSDIC...	122		N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
Q8CIB5-242-unknown	LLDKAK...	242	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34101
Q8CIB5-276-unmodified	YYSFFD...	276		N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...FKPQAL	241	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34101
...LDKAKT	247	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000120918
...NNSDKE	341	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000118214
...TSGWV	680	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	241	PQAL.\|.LLDK	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)