P47879: Insulin-like growth factor-binding protein 4

General Information

Protein names	- Insulin-like growth factor-binding protein 4 - IBP-4 - IGF-binding protein 4 - IGFBP-4
Gene names	Igfbp4
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	P47879

8 N-termini

6 C-termini

6 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MLPFGLVAAL LLAAGPRPSL GDEAIHCPPC SEEKLARCRP PVGCEELVRE PGCGCCATCA
        70         80         90        100        110        120
LGLGMPCGVY TPRCGSGMRC YPPRGVEKPL RTLMHGQGVC TELSEIEAIQ ESLQTSDKDE
       130        140        150        160        170        180
SEHPNNSFNP CSAHDHRCLQ KHMAKIRDRS KMKIVGTPRE EPRPVPQGSC QSELHRALER
       190        200        210        220        230        240
LAASQSRTHE DLFIIPIPNC DRNGNFHPKQ CHPALDGQRG KCWCVDRKTG VKLPGGLEPK
       250
GELDCHQLAD SFQE

Isoforms

Sequence View

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Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

8 N-termini - 6 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P47879-21-acetylation	GDEAIH...	21	acetylation-		N-TAILS		Overall CM.	auf dem Keller U.: A statistics-based platform for quantitative N-terminome...	20305283
P47879-22-unknown	DEAIHC...	22		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P47879-22-unknown	DEAIHC...	22		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P47879-22-unknown	DEAIHC...	22		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33572
P47879-22-unmodified	DEAIHC...	22			N-TAILS		Overall CM.	Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies...	20208520
P47879-22-unmodified	DEAIHC...	22			unknown			Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from...	20208520
P47879-22-unmodified	DEAIHC...	22			N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
P47879-25-unknown	IHCPPC...	25		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33573
P47879-80-5oxothiomorpholine-3-carboxylic-acid	CYPPRG...	80			N-TAILS		Overall CM.	Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies...	20208520
P47879-92-unknown	TLMHGQ...	92		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33574
P47879-127-unknown	SFNPCS...	127		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33575
P47879-167-unknown	QGSCQS...	167		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC33576
P47879-167-unknown	QGSCQS...	167		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34626

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RPSLGD	21	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33572
...LGDEAI	24	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33573
...EKPLRT	91	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33574
...EHPNNS	126	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33575
...PRPVPQ	166	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC33576
...PRPVPQ	166	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34626
...DSFQE	254	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	21	SLGD.\|.DEAI	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,
MMP2_MOUSE	24	DEAI.\|.IHCP	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,
MMP2_MOUSE	91	PLRT.\|.TLMH	inferred from experiment	unknown	MEROPS		Merops MMP2_MOUSE -> IBP4_MOUSE @91
MMP2_MOUSE	126	PNNS.\|.SFNP	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,
MMP2_MOUSE	166	PVPQ.\|.QGSC	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,
MMP9_MOUSE	166	PVPQ.\|.QGSC	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)