Q6ZWX6: Eukaryotic translation initiation factor 2 subunit 1

General Information

Protein names	- Eukaryotic translation initiation factor 2 subunit 1 - Eukaryotic translation initiation factor 2 subunit alpha - eIF-2-alpha - eIF-2A - eIF-2alpha
Gene names	Eif2s1
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q6ZWX6

4 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPGLSCRFYQ HKFPEVEDVV MVNVRSIAEM GAYVSLLEYN NIEGMILLSE LSRRRIRSIN
        70         80         90        100        110        120
KLIRIGRNEC VVVIRVDKEK GYIDLSKRRV SPEEAIKCED KFTKSKTVYS ILRHVAEVLE
       130        140        150        160        170        180
YTKDEQLESL FQRTAWVFDD KYKRPGYGAY DAFKHAVSDP SILDSLDLNE DEREVLINNI
       190        200        210        220        230        240
NRRLTPQAVK IRADIEVACY GYEGIDAVKE ALRAGLNCST ETMPIKINLI APPRYVMTTT
       250        260        270        280        290        300
TLERTEGLSV LNQAMAVIKE KIEEKRGVFN VQMEPKVVTD TDETELARQL ERLERENAEV
       310
DGDDDAEEME AKAED

Isoforms

Sequence View

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q6ZWX6-1-unknown	MPGLSC...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q6ZWX6-200-unmodified	YGYEGI...	200		N-TAILS		Overall CM.	Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9...	20305284
Q6ZWX6-236-unknown	VMTTTT...	236	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34034
Q6ZWX6-256-unknown	AVIKEK...	256	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC30651

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...APPRYV	235	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34034
...LNQAMA	255	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30651
...AKAED	315	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP2_MOUSE	235	PRYV.\|.VMTT	inferred from experiment	unknown	MEROPS	Overall CM	Prudova A et al.:Multiplex N-terminome analysis ... (M10.004)	20305284,
CATE_MOUSE	255	QAMA.\|.AVIK	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> IF2A_MOUSE @255

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)